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Your search keyword '"Wagner, George C."' showing total 9 results
Start Over Author "Wagner, George C." Publisher springer-verlag
9 results on '"Wagner, George C."'

9. Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Author

Conney AH, Lou YR, Nghiem P, Bernard JJ, Wagner GC, and Lu YP

Subjects
Administration, Oral, Animals, Apoptosis radiation effects, Caffeine administration & dosage, Mice, Neoplasms, Radiation-Induced pathology, Skin Neoplasms etiology, Skin Neoplasms pathology, Adipose Tissue drug effects, Caffeine pharmacology, Neoplasms, Radiation-Induced prevention & control, Physical Conditioning, Animal, Skin Neoplasms prevention & control, Tea, Ultraviolet Rays
Abstract

Oral administration of green tea, black tea, or caffeine (but not the decaffeinated teas) inhibited ultraviolet B radiation (UVB)-induced skin carcinogenesis in SKH-1 mice. Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine's inhibition of UVB-induced carcinogenesis. The regular teas or caffeine increased locomotor activity and decreased tissue fat. In these studies, decreased dermal fat thickness was associated with a decrease in the number of tumors per mouse. Administration of caffeine, voluntary exercise, and removal of the parametrial fat pads all stimulated UVB-induced apoptosis, inhibited UVB-induced carcinogenesis, and stimulated apoptosis in UVB-induced tumors. These results suggest that caffeine administration, voluntary exercise, and removal of the parametrial fat pads inhibit UVB-induced carcinogenesis by stimulating UVB-induced apoptosis and by enhancing apoptosis in DNA-damaged precancer cells and in cancer cells. We hypothesize that tissue fat secretes antiapoptotic adipokines that have a tumor promoting effect.

Published
2013
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