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The clonidine transdermal therapeutic system (Catapres-TTS) delivers clonidine by diffusion through an adhesive plaster on the skin. It is available in sizes 2.5, 5 and 7 mg to deliver daily 0.1, 0.2, or 0.3 mg clonidine respectively. Steady-state levels are reached in three days. The plaster is changed weekly. There is no withdrawal syndrome as clonidine levels fall slowly after removal of the plaster (Fig. 1) (1). We compared the efficacy of clonidine-TTS with the well-established drugs atenolol and atenolol + chlorthalidone in mild to moderate hypertension.