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Sick building syndrome (SBS) is commonly found among office staff. There have been few studies on SBS among hotel staff. The main objective of this research was to establish a risk factor model related to the occurrence of SBS among hotel staff. A questionnaire on SBS was used to survey 246 hotel staff based on purposive sampling. Significant factors were detected using chi- square and likelihood ratio tests while binary logistic regression was used to determine the significant difference among personal information, workplace characteristics, and environmental and psychosocial factors in relation to the occurrence of SBS. The outcome of the evaluation indicates the prevalence of SBS as about 7%. The statistical factors related to SBS were female staff (OR = 20.52, 95%CI = 2.91-144.92), smoking habits (OR = 10.67, 95%CI = 1.94-58.61), and presence of animals (OR = 8.09, 95%CI = 2.52-26.01). This study indicates that female smokers surrounded by animals had an elevated risk of SBS. This study could be useful for guiding hotel staff to avert health risk behavior. [ABSTRACT FROM AUTHOR]