1. Giant pancreatic insulinoma. The bigger the worse? Report of two cases and literature review
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Benedetto Ielpo, Catalina Oliva, Riccardo Caruso, Yolanda Quijano, Emilio Vicente, Isabel Fabra, Eduardo Diaz, Sergio Olivares, Ramon Puga, Hipolito Duran, and Valentina Ferri
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Pancreatic Insulinoma ,endocrine system ,Text mining ,endocrine system diseases ,Neuroendocrine tumor ,business.industry ,MEDLINE ,Medicine ,Surgery ,business ,Bioinformatics ,Article ,Giant insulinoma - Abstract
INTRODUCTIONGiant pancreatic insulinomas are rare endocrine tumors. We describe 2 cases reviewing the current literature.PRESENTATION OF CASEWe report herein 2 female patients affected by giant insulinomas of 14cm and 6cm, respectively. Symptomatic hypoglycemia episodes occurred during 4 months in first case and 3 years in the second one until diagnosis. Both patients were successfully treated performing a distal pancreatectomy with splenic preservation in the first case and a Whipple's procedure in the second one.DISCUSSIONUp to now only 7 cases have been reported previously. Insulinomas larger than 3cm accounts for less than 5% of all. This literature review shows that despite the size hypoglycemic symptoms varies from 1 day to 3 years and only 1 out of 9 cases reported presented lymph nodes metastases. No recurrences have been described.CONCLUSIONOne of the cases here described (14cm) is the largest presented in the literature. Despite the size, giant insulinoma is related apparently neither to metastases nor to the recurrences.
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