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Start Over Author "Lars Bräuer" Publisher swiss chemical society
2 results on '"Lars Bräuer"'

1. Enzymatic C–C-Coupling Prenylation: Bioinformatics – Modelling – Mechanism – Protein-Redesign – Biocatalytic Application

Author

Ludger Wessjohann, Svetlana Zakharova, Diana Schulze, Julia Kufka, Roman Weber, Lars Bräuer, and Wolfgang Brandt

Subjects
Aromatic prenyltransferases, Biocatalysis, Protein-redesign, Substrate specificity, Terpene synthases, Chemistry, QD1-999
Abstract

The functional role of isoprenoids and especially enzymatic prenylation in nature and human application is briefly covered, with the focus on bioinformatical, mechanistical and structural aspects of prenyltransferases and terpene synthases. These enzymes are as yet underrepresented but perspectively useful biocatalysts for C–C couplings of aromatic and isoprenoid substrates. Some examples of the successful use in chemoenzymatic synthesis are given including an application for the otherwise difficult synthesis of Kuhistanol A. Computational structure-based site-directed mutagenesis can be used for rational enzyme redesign to obtain altered substrate and product specificities, which is demonstrated for terpene cyclases.

Published
2009
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2. Enzymatic C–C-Coupling Prenylation: Bioinformatics – Modelling – Mechanism – Protein-Redesign – Biocatalytic Application

Author

Diana Schulze, Roman Weber, Ludger A. Wessjohann, Wolfgang Brandt, Lars Bräuer, Julia Kufka, and Svetlana Zakharova

Subjects
Functional role, chemistry.chemical_classification, Aromatic prenyltransferases, Mechanism (biology), Chemistry, Substrate specificity, Mutagenesis (molecular biology technique), General Medicine, General Chemistry, Protein-redesign, Terpene, C c coupling, Enzyme, Biochemistry, Prenylation, Biocatalysis, Terpene synthases, QD1-999
Abstract

The functional role of isoprenoids and especially enzymatic prenylation in nature and human application is briefly covered, with the focus on bioinformatical, mechanistical and structural aspects of prenyltransferases and terpene synthases. These enzymes are as yet underrepresented but perspectively useful biocatalysts for C–C couplings of aromatic and isoprenoid substrates. Some examples of the successful use in chemoenzymatic synthesis are given including an application for the otherwise difficult synthesis of Kuhistanol A. Computational structure-based site-directed mutagenesis can be used for rational enzyme redesign to obtain altered substrate and product specificities, which is demonstrated for terpene cyclases.

Published
2009

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