1. Helicobacter pylori and gut microbiota modulate energy homeostasis prior to inducing histopathological changes in mice.
- Author
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Khosravi Y, Bunte RM, Chiow KH, Tan TL, Wong WY, Poh QH, Doli Sentosa IM, Seow SW, Amoyo AA, Pettersson S, Loke MF, and Vadivelu J
- Subjects
- Animals, Gastric Mucosa microbiology, Ghrelin metabolism, Helicobacter Infections microbiology, Humans, Insulin metabolism, Leptin metabolism, Mice, Peptide YY metabolism, Energy Metabolism, Gastric Mucosa metabolism, Gastrointestinal Microbiome, Helicobacter pylori metabolism
- Abstract
Helicobacter pylori have been shown to influence physiological regulation of metabolic hormones involved in food intake, energy expenditure and body mass. It has been proposed that inducing H. pylori-induced gastric atrophy damages hormone-producing endocrine cells localized in gastric mucosal layers and therefore alter their concentrations. In a recent study, we provided additional proof in mice under controlled conditions that H. pylori and gut microbiota indeed affects circulating metabolic gut hormones and energy homeostasis. In this addendum, we presented data from follow-up investigations that demonstrated H. pylori and gut microbiota-associated modulation of metabolic gut hormones was independent and precedes H. pylori-induced histopathological changes in the gut of H. pylori-infected mice. Thus, H. pylori-associated argumentation of energy homeostasis is not caused by injury to endocrine cells in gastric mucosa.
- Published
- 2016
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