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Your search keyword '"Aguiar ERGR"' showing total 2 results
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2 results on '"Aguiar ERGR"'

1. Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Author

Mendes de Almeida, V, Engel, DF, Ricci, MF, Cruz, CS, Lopes, ÍS, Alves, DA, d' Auriol, M, Magalhães, J, Machado, EC, Rocha, VM, Carvalho, TG, Lacerda, LSB, Pimenta, JC, Aganetti, M, Zuccoli, GS, Smith, BJ, Carregari, VC, da Silva Rosa, E, Galvão, I, Dantas Cassali, G, Garcia, CC, Teixeira, MM, André, LC, Ribeiro, FM, Martins, FS, Saia, RS, Costa, VV, Martins-de-Souza, D, Hansbro, PM, Marques, JT, Aguiar, ERGR, Vieira, AT, Mendes de Almeida, V, Engel, DF, Ricci, MF, Cruz, CS, Lopes, ÍS, Alves, DA, d' Auriol, M, Magalhães, J, Machado, EC, Rocha, VM, Carvalho, TG, Lacerda, LSB, Pimenta, JC, Aganetti, M, Zuccoli, GS, Smith, BJ, Carregari, VC, da Silva Rosa, E, Galvão, I, Dantas Cassali, G, Garcia, CC, Teixeira, MM, André, LC, Ribeiro, FM, Martins, FS, Saia, RS, Costa, VV, Martins-de-Souza, D, Hansbro, PM, Marques, JT, Aguiar, ERGR, and Vieira, AT

Abstract

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.

Published
2023

2. Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Author

Mendes de Almeida V, Engel DF, Ricci MF, Cruz CS, Lopes ÍS, Alves DA, d' Auriol M, Magalhães J, Machado EC, Rocha VM, Carvalho TG, Lacerda LSB, Pimenta JC, Aganetti M, Zuccoli GS, Smith BJ, Carregari VC, da Silva Rosa E, Galvão I, Dantas Cassali G, Garcia CC, Teixeira MM, André LC, Ribeiro FM, Martins FS, Saia RS, Costa VV, Martins-de-Souza D, Hansbro PM, Marques JT, Aguiar ERGR, and Vieira AT

Subjects
Animals, Mice, SARS-CoV-2, Anti-Bacterial Agents, Disease Progression, COVID-19, Gastrointestinal Microbiome
Abstract

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae . transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.

Published
2023
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