1. Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn
- Author
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Tan Phat Nguyen, Van Kieu Nguyen, Dinh Tri Mai, Nguyen Kim Tuyen Pham, Bui Linh Chi Huynh, Dang Cam Tu Phan, Trong D. Tran, Thi Thao Linh Tran, Thi Anh Tuyet Nguyen, Nguyen Tien Trung, Thuc-Huy Duong, and Thi Ngoc Mai Tran
- Subjects
biology ,010405 organic chemistry ,Chemistry ,Chemical structure ,Alkaloid ,Organic Chemistry ,Ricinus ,Euphorbiaceae ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,HeLa ,010404 medicinal & biomolecular chemistry ,Genus ,Cell culture ,Human cancer - Abstract
From the leaves of Ricinus communis Linn., one new alkaloid, named ricicomin A (1) together with three known ones, ricinine (2), N-demethylricinine (3) and 4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (4) were justified by repeated chromatographic methods. Their structures were determined by comprehensive IR, HR-ESI-MS and NMR analyses. Compound 4 was identified for the first time from the genus Ricinus. DFT-NMR chemical shift calculations and subsequent DP4+ probability methods were applied to confirm the chemical structure of 1. Compounds 1–3 did not display cytotoxic effect against three human cancer cell lines (MCF-7, HepG2 and HeLa) using SRB assay.
- Published
- 2020
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