1. Treatment of human brucellosis with rifampin plus minocycline.
- Author
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Cascio A, Scarlata F, Giordano S, Antinori S, Colomba C, and Titone L
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Brucella classification, Brucellosis diagnosis, Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Infusions, Intravenous, Italy, Male, Middle Aged, Recurrence, Retrospective Studies, Risk Assessment, Treatment Outcome, Brucella drug effects, Brucellosis drug therapy, Drug Therapy, Combination administration & dosage, Minocycline administration & dosage, Rifampin administration & dosage
- Abstract
In order to evaluate the efficacy and tolerability of a high intravenous dose of rifampin plus oral minocycline (administered daily for 3 weeks) for the treatment of acute brucellosis, we retrospectively reviewed the outcome of 239 consecutive patients (135 adults and 104 children) diagnosed and treated over a 17-year period in Italy. The combination used resulted in 100% response and a relapse rate lower than 2%. Fifty-two (30 adults and 22 children) (29.8%) complained of mild adverse effects including an increase in aspartate aminotransferase (>250 IU) observed in 12 cases and considered related to rifampin and in 11 cases a reversible hyperpigmentation of the tongue attributed to minocycline. A randomized prospective comparative study should be performed to confirm our encouraging results.
- Published
- 2003
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