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We recently introduced a method to derive intra-tumor heterogeneity (ITH) from a single copy number measurement. This method stratifies patients for survival and could potentially help to identify low and high-risk patients with clinical relevance., Competing Interests: E.v.D., L.V. and D.M.M. are listed as inventors in a pending patent application (NL82151) filed by Oncode Institute on behalf of the Academisch Medisch Centrum, covering the content of the paper. T.v.d.B. declares no conflict of interest., (© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.)

By using marker-free lineage tracing in combination with quantitative analysis, we recently revealed cancer stem cell functionality in established human colon cancer is not intrinsically defined, but fully spatiotemporally regulated.