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Your search keyword '"Gregory K. Wilkerson"' showing total 2 results
Start Over Author "Gregory K. Wilkerson" Publisher taylor & francis group
2 results on '"Gregory K. Wilkerson"'

1. Lymphocytes upregulate CD36 in adipose tissue and liver

Author

Jacob Couturier, Alli M. Nuotio-Antar, Neeti Agarwal, Gregory K. Wilkerson, Pradip Saha, Viraj Kulkarni, Samir K. Lakhashe, Juan Esquivel, Pramod N. Nehete, Ruth M. Ruprecht, K. Jagannadha Sastry, Jennifer M. Meyer, Lori R. Hill, Jordan E. Lake, Ashok Balasubramanyam, and Dorothy E. Lewis

Subjects
adipose tissue, cd36, metabolism, obesity, t cells, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981
Abstract

CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5–40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.

Published
2019
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2. Lymphocytes upregulate CD36 in adipose tissue and liver

Author

Viraj Kulkarni, Jacob Couturier, Ashok Balasubramanyam, Ruth M. Ruprecht, Lori R. Hill, Alli M. Nuotio-Antar, Gregory K. Wilkerson, Neeti Agarwal, Juan Esquivel, K. Jagannadha Sastry, Dorothy E. Lewis, Jennifer M. Meyer, Samir K. Lakhashe, Pradip K. Saha, Pramod N. Nehete, and Jordan E. Lake

Subjects
CD36 Antigens, CD4-Positive T-Lymphocytes, Male, obesity, CD36, Adipose tissue, 030204 cardiovascular system & hematology, CD8-Positive T-Lymphocytes, lcsh:Diseases of the endocrine glands. Clinical endocrinology, lcsh:Physiology, Mice, 0302 clinical medicine, Medicine, t cells, 0303 health sciences, biology, lcsh:QP1-981, lcsh:Cytology, Brief Report, hemic and immune systems, Up-Regulation, adipose tissue, medicine.anatomical_structure, Liver, Lymph, medicine.symptom, circulatory and respiratory physiology, Histology, Inflammation, Spleen, cd36, 03 medical and health sciences, Downregulation and upregulation, parasitic diseases, Animals, Humans, Scavenger receptor, lcsh:QH573-671, 030304 developmental biology, lcsh:RC648-665, business.industry, Cancer, Cell Biology, medicine.disease, Macaca mulatta, Mice, Inbred C57BL, biology.protein, Cancer research, business, metabolism
Abstract

CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5–40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.

Published
2019

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