1. Three new cardenolides from the fruits of Cascabela thevetia (L.) Lippold and their cytotoxic activities.
- Author
-
Long J, Ouyang JC, Luo YH, Wu QJ, Liao XT, Chen ZL, Wang QL, Liang XY, Liu L, Yang XM, and Li XS
- Subjects
- Humans, Cardenolides pharmacology, Cardenolides chemistry, Fruit, HeLa Cells, Molecular Structure, Cell Line, Tumor, Thevetia chemistry, Antineoplastic Agents, Phytogenic pharmacology, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents
- Abstract
Phytochemical investigations on the fruits of Cascabela thevetia (L.) Lippold led to obtain three new cardenolides ( 1 - 3 ) and five known analogues ( 4 - 7 ). Their structures were elucidated by means of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopic data analysis. Compounds 1 and 2 represent the first examples of naturally occurring cardenolides with 19- nor -5(10)-ene group and α - l -3-demethyl-thevetose, respectively. Compound 3 is a rare C -nor- D-homocardenolide in nature. All isolated cardenolides ( 1 - 7 ) were evaluated for their cytotoxic activities against four human cancer cell lines (MCF-7, HCT-116, HeLa and HepG2), and the results indicated the compounds with sugar units ( 1 , 2 , 4 , and 5 ) exhibited stronger cytotoxic activities with IC
50 values ranging between 0.022 and 0.308 μ M.- Published
- 2024
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