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Start Over Author "Lohidasan, S." Publisher taylor & francis health sciences
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1. Isolation, characterisation and investigation of in vitro antidiabetic and antioxidant activity of phytoconstituents from fruit of Momordica charantia Linn.

Author

Kulkarni P, Lohidasan S, and Mahadik K

Subjects
Antioxidants chemistry, Humans, Hypoglycemic Agents chemistry, Inhibitory Concentration 50, Phytochemicals chemistry, Plant Extracts pharmacology, alpha-Amylases metabolism, alpha-Glucosidases metabolism, Antioxidants isolation & purification, Antioxidants pharmacology, Fruit chemistry, Hypoglycemic Agents isolation & purification, Hypoglycemic Agents pharmacology, Momordica charantia chemistry, Phytochemicals pharmacology
Abstract

The dry powder of MC fruits was extracted by maceration, ultrasonication, liquid-liquid partition and soxhlation. The in vitro antidiabetic and antioxidant assays were used to screen extracts and fractions. Refluxed and liquid partitioned extracts were fractionated using petroleum ether and ethyl acetate and purified with the help of preparative HPLC to give 2 phytoconstituents M1 and M2 respectively. Compound M1 (1) was identified as charantin and Compound M2 (2) was identified as momordicinin using spectral studies. Momordicinin showed potent α-amylase inhibitory activity with IC 50 15.86μg/ml which was reported for the first time.

Published
2021
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