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Embryonic metanephros is the mammalian renal anlagen, which is considered as a potential source for the regeneration of functional whole kidneys. Some studies reported that metanephros implanted into unilateral nephrectomized animals can develop into kidney tissue. However, kidneys are nephrotoxic in renal failure patients, and whether metanephros can grow in nephrotoxic has not been reported. This study aims to investigate the growth of metanephros in acute nephrotoxic environment and analyze the therapeutic effect of metanephros microenvironment on acute kidney injury (AKI). AKI was induced in 200 g Wistar rats by giving intramuscular injections of 50% glycerol (10 mL/kg) in their hind limbs. 45 rats were divided randomly into three groups (control, glycerin, and metanephros). Metanephros group was transplanted two metanephroi (embryonic day 15) into the renal capsule of AKI rats. Glycerin group was AKI rats without transplantation. Control group was untreated. Mature glomeruli and tubules were detected in the grafts in metanephros group, which means that metanephroi can grow into tissues with mature kidney structure under acute nephrotoxic. Then, we assessed the renal function of host rats and found that there were fewer tubular necrosis in metanephros group than glycerin group, and the serum creatinine and urea nitrogen were significantly lower in metanephros group than glycerin group. These results suggested that embryonic metanephroi can grow into tissues with mature kidney structure under acute nephrotoxic, and the graft microenvironment was effective in inhibiting the progression of AKI, which provides a new approach for the treatment of acute renal injury. [ABSTRACT FROM AUTHOR]

Several psychological theories and models of wisdom have been developed. Despite converging trend from different theories and models in the understanding of wisdom, intervention plans or attempts to facilitate wisdom have been meager. In this study, different components of the MORE Life Experience Model of Wisdom were taken as intervention targets, and these components were targeted through mindfulness training, journal writing, narrative simulation, and case discussion on leadership virtues. The basic purpose was to seek the answer for the possibilityof development of wisdom in individuals by testing MORE modeland we plan to answer this by fulfilling two aims: first,to find empirical support for the MORE life experience model,we wanted to see whether MORE components predict participants’ self-rated wisdom scores; and second,to use this model as an intervention tool to foster wisdom.Intervention, lasted for 18 weeks, was done among 160 students (age range 19–22 years) enrolled for “leadership” course. Complete data were obtained from 108 participants. Result suggests Habitual Action (β = 0.24,p < 0.05), Personal Mastery (β = 0.24,p < 0.05), and Suppression (β = 0.20,p < 0.05) predicted Cognitive Wisdom; Personal Mastery (β = 0.34,p < 0.001;β = 0.43,p < 0.01) and Mindfulness (β = 0.23,p < 0.05;β = 0.26,p < 0.05) predicted Affective and Reflective Wisdom; and composite wisdom was predicted by Mindfulness (β = 0.33,p < 0.001) and Reappraisal (β = 0.24,p < 0.01). After intervention there were changes in Suppression (d = 0.34) and Habitual Action (d = 0.26). The study concluded with an affirmation to the conviction that wisdom may be amenable to the intervention. [ABSTRACT FROM AUTHOR]