1. Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.
- Author
-
Li, Yanli, Bonner, Matthew R., Browne, Richard W., Deng, Furong, Tian, Lili, Jim) Zhang, Junfeng (, Swanson, Mya, Rittenhouse-Olson, Kate, Farhat, Zeinab, and Mu, Lina
- Subjects
- *
AIR pollution , *PANEL analysis , *CHEMOKINES , *AIR pollution control , *INFLAMMATORY mediators , *BODY mass index , *INTERLEUKIN-8 - Abstract
Background: Despite the in vitro and in vivo evidence, studies are limited in evaluating whether chemokines are potential inflammatory mediators in response to air pollution exposure in humans. Methods: We conducted a panel study coinciding with the Beijing Olympics, when temporary air pollution controls were implemented. We measured a suite of serum chemokines among healthy adults before, during and after the Olympics, respectively. Linear mixed-effect models were used to evaluate changes in chemokine levels over the three time periods. Results: In response to the 50% drop in air pollution levels during the games, levels of RANTES, MCP-2, and TARC decreased by 25.8%, 20.9% and 35.3%, respectively (p < 0.001) from pre-Olympics, and then increased by 45.8%, 34.9% and 61.5%, respectively (p < 0.001) after the games when air pollution levels went up again. Similar patterns were observed in subgroup analyses by sex, age, smoking and body mass index. GRO-α and IL-8 decreased significantly during the games (22.5% and 30.4%), and increased non-significantly after the games. Eotaxin-1 only increased significantly from during- to post-games. Conclusions: The strongest associations with air pollution levels were observed among RANTES, TARC and MCP-2. Those chemokines may play important roles in the air pollution-induced inflammatory pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF