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Start Over Author "Xiao, Jia" Topic animal experimentation Publisher taylor & francis ltd

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1 results on '"Xiao, Jia"'

1. Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice.

Author

Li, Jing-Jing, Gao, Hao, Lv, Yi, Li, Mian-Huan, Ren, Chao-Ran, So, Kwok-Fai, and Xiao, Jia

Subjects
*ANIMAL experimentation, *BIOLOGICAL products, *FATTY liver, *HEPATITIS, *HISTOLOGY, *MEDICINAL plants, *MICE, *ORGANIC compounds, *POLYMERASE chain reaction, *RESEARCH funding, *STATISTICS, *WESTERN immunoblotting, *DATA analysis, *CHRONIC hepatitis B, *ONE-way analysis of variance
Abstract

A hepatitis B virus (HBV) transgenic mice model was used to establish the fatty liver superimposed model by feeding the methionine choline-deficient (MCD) diet for 8 weeks, with or without the gavage of 2 mg/kg zeaxanthin dipalmitate (ZD) three times per week. Both wild-type and HBV transgenic mice, with MCD diet, gained typical non-obese non-alcoholic steatohepatitis (NASH) and HBV symptoms. Coadministration with ZD exhibited evident therapeutic effects through alleviating those pathological events. Moreover, long-term vehicle-ZD treatment was found to be safe. Thus, ZD is a promising and safe hepato-protective agent against hepatic injury induced by superimposed HBV and NASH in non-obese mice. [ABSTRACT FROM AUTHOR]

Published
2017
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