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1. TEIPP peptides: exploration of unTAPped cancer antigens.

Author

Marijt, Koen A., Van Der Burg, Sjoerd H., and van Hall, Thorbald

Subjects
*PEPTIDES, *HISTOCOMPATIBILITY class I antigens, *T cells, *ANTIGENS, *CANCER
Abstract

The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which 'hidden' antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing. [ABSTRACT FROM AUTHOR]

Published
2019
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