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The promoter of prosocial behavior in fighting against the COVID-19 pandemic needs to be examined. Here, we examined the effect of experienced awe through cross-sectional (Study 1), a 3-wave longitudinal (Study 2) and experimental (Study 3–4) approaches. Study 1 showed that dispositional awe positively predicted one's prosocial behavior in the pandemic (N = 1281). Study 2 (N = 332) observed that experienced awe predicted higher prosociality, and this relationship was serially mediated by connectedness and empathy. Study 3 (N = 153) and 4 (N = 156) confirmed that elicited awe, compared to that of amusement and neutrality, promoted multiple types of prosociality (Study 3) and willingness of blood donation (Study 4) via serial mediation of connectedness and empathy. These findings suggest that the experience of awe increases one's connectedness to the world, which in turn enhances empathic concern and prosociality in pandemic fighting. [ABSTRACT FROM AUTHOR]