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To analyze the feasibility of and pain-related tolerance to a maximal cardiopulmonary exercise test (CPET), and the relationship between the aerobic capacity and central sensitization (CS) in patients with chronic low back pain (CLBP). An observational study, combining a cross-sectional and a prospective 24-hour follow-up was performed. Participants underwent a maximal CPET on a cycle ergometer and were assessed with three measures of CS (CS Inventory, quantitative sensory testing and heart rate variability). Before the CPET, immediately afterwards and 24 h after, the Pain Response Questionnaire (PRQ) was filled out. The CPET was considered feasible when >80% performed maximally, and tolerable when <20% reported relevant pain increase, body reactions and additional pain medication use in the PRQ. Multiple regression analyses were applied to assess the relationship between the aerobic capacity (VO2max) and CS measures, corrected for confounders. 74 patients with CLBP participated of which 30 were male, mean age was 40.4 years (SD: 12.4) and median VO2max was 23.9 ml/kg/min (IQR: 18.2–29.4). CPET was completed by 92%. No serious adverse events occurred. A relevant pain increase was reported in the upper legs by 40% immediately after CPET and by 28% 24 h afterwards, 27% reported body reactions after 24 h, and 22% increased pain medication use 24 h after CPET. Very weak and not significant relations (rpartial=−0.21 to 0.05; p > 0.10) were observed between aerobic capacity and CS measures. A maximal CPET is feasible in patients with CLBP. Most, but not all, tolerated it well. CS was not related to aerobic capacity. Maximal CPET is feasible in patients with CLBP and well tolerated by most patients. Maximal CPET can be safely applied to assess the aerobic capacity of patients with CLBP. Aerobic capacity is unrelated to central sensitization. Outcomes of a maximal CPET and the pain response to straining activity can be used to provide valid information for the decision-making of exercise therapy. [ABSTRACT FROM AUTHOR]

The aim of this study was to analyse the detraining process that occurs during a season break, and its influence on the performance, anthropometrics, and biomechanics of young swimmers. The sample included 54 young swimmers (22 boys: 12.79 ± 0.71 years; 32 girls: 11.78 ± 0.85 years). Performance for the 100 m freestyle and anthropometric and biomechanical variables were evaluated as main determinants. Performance impaired significantly for boys (2.17%) and girls (1.91%). All anthropometric variables increased between moments of assessment for boys and girls. Overall, the boys enhanced all biomechanical variables during the detraining period, and girls showed mixed results. For both sexes, the stroke index was the variable with the highest increase (boys: Δ = 16.16%; d = 0.89; p = 0.001; girls: Δ = 19.51%; d = 1.06; p = 0.002). Hierarchical linear modelling showed that the height retained the amount of impairment in the performance. One unit of increase in the height (cm) led to less 0.41 s impairment in the performance. Present data indicated that during an 11-weeks detraining period, young swimmers impaired their performance, but the determinant factors showed an impaired relationship. This increase in the determinant factors is mainly related to the increase in the swimmers' anthropometrics. Moreover, the increase in height was responsible for retaining the performance impairment. [ABSTRACT FROM AUTHOR]

The objective of this study is to explore the transcriptomic and biologic variables characterizing the longitudinal rehabilitation intervention of patients with hospital-acquired deconditioning (HAD). This prospective clinical trial recruited HAD patients (n = 10) who spent ≥3 weeks hospitalized and then received inpatient rehabilitation. Functional improvement was measured using the Functional Independence Measure (FIM). Transcriptomic and biological variables were recorded at rehabilitation admission and 1, 2, 4, and 6 weeks post-admission. RNA sequencing studied the temporal changes of gene expression in leukocytes. Between-subject transcriptome comparisons were performed using principle component analysis. Within-subject changes in gene expression were analyzed using a gene ontology hierarchical clustering to identify common biological terms. Heart rate, weight, albumin, creatinine, and complete blood counts were analyzed. Patients average age was 50.6 ± 7.2, FIM increased during inpatient rehabilitation (p = 0.01), weight increased (p = 0.01), lymphocytes decreased (p = 0.05), neutrophil increased (0.03) and red cell distribution width decreased (p = 0.05). The temporal profiles of gene expression revealed within-patient homogeneity and between-patients heterogeneity. The biological terms "bone morphogenesis" and "muscle cell development" were the most significantly enriched differentially expressed genes. Transcriptomic and biologic markers paralleled the functional improvements of HAD patients during inpatient rehabilitation. Transcriptomic analyses were consistent with the cohort heterogeneity. Enrichment of the biological pathways bone morphogenesis and muscle cell development constituted evidence at the gene expression level of the effect of rehabilitation. Larger studies of various rehabilitation patient groups may increase gene expression profile homogeneity. Objective transcriptomic and biologic markers have the potential to improve the rehabilitation of HAD patients. Novel gene expression methods are increasingly being integrated into clinical practice and may apply to rehabilitation. Patients with hospital-acquired deconditioning (HAD) enriched gene expression of pathways targeted by inpatient rehabilitation such as bone morphogenesis and muscle cell development. The gene expression paralleled functional improvement of HAD patients. These data demonstrated the feasibility of molecular methods to identify markers of rehabilitation success in HAD patients. [ABSTRACT FROM AUTHOR]

The aims of this study were to investigate changes in selected performance measures during an off-season period, their association, and the potential role of age and previous hamstring injury in semi-professional and amateur football players. Seventy-four male players (age: 25 ± 4 years, stature: 178.0 ± 6.6 cm, body mass: 74.9 ± 8.1 kg) were assessed at the beginning and end of the off-season summer-period for sprint, change-of-direction performance and eccentric hamstring strength. Small to medium increases in sprint times were observed at 5 (d = 0.26, p = 0.057), 10 (d = 0.42, p < 0.001) and 30 m (d = 0.64, p < 0.001). Small (d = −0.23, p = 0.033) improvements were observed for COD performance, and no changes in eccentric hamstring strength (d = 0.10, p = 0.317). The changes in the outcomes were not affected by age (p = 0.449 to 0.928) or previous hamstring injury (p = 0.109 to 0.995). The impaired sprint performance was not related to changes in eccentric hamstring strength (r = −0.21 to 0.03, p = 0.213 to 0.856), instead, changes in COD performance were associated with changes in eccentric hamstring strength (r = −0.42, p = 0.008). [ABSTRACT FROM AUTHOR]

Purpose: To examine the efficacy of an occupational therapy activity pacing intervention with deconditioned older adults in rehabilitation. Method: Randomised, single-blind controlled trial of deconditioned older adults admitted for rehabilitation following treatment of an acute medical condition, allocated to intervention [n = 51, males = 14, mean age = 80(8)] or control [n = 49, males = 12, mean age = 81(7)] group. The intervention group received individual and group activity pacing education with practice and application of techniques to daily activities and the home environment, while the control group received a typical occupational therapy program, which included brief activity pacing education. Outcomes included participation in daily living skills, health status (including pain and fatigue symptoms), self-efficacy in daily activities and activity pacing techniques using the Australian Therapy Outcome Measures-Occupational Therapy (AusTOMs-OT), Short Form-36 Health Survey (SF-36), Self-Efficacy Gauge and Activity Pacing Assessment. Results: No differences in groups at admission. Comparison at discharge and three months post discharge using 2 × 2 mixed ANOVA demonstrated small differences in only one scale of the activity limitation domain of the AusTOMs-OT. No significant differences were found in other scales or domains of the AusTOMs-OT, nor secondary outcome measures. Conclusion: Activity pacing in addition to typical occupational therapy during inpatient rehabilitation did not demonstrate benefits to participants in the management of their daily activities on returning home post hospitalisation. Activity pacing has been identified as one of the commonly used occupational therapy interventions utilised with deconditioned older adults in rehabilitation. An activity pacing intervention in conjunction with typical occupational therapy demonstrated no benefits for deconditioned older adults over typical occupational therapy which included basic education on this topic. Continuation of the activity pacing intervention into the outpatient setting may be of benefit to older adults and requires further investigation. [ABSTRACT FROM AUTHOR]

This study evaluates the effects of training and detraining on ankle proprioception in terms of kinesthesia in adult women. Sixty participants were randomly assigned to three groups. Tai Chi and Brisk Walking Groups went through a 16-week training period followed by an eight-week detraining period. The ankle plantar-flexion, dorsal-flexion, inversion, and eversion kinesthesia were measured every four weeks. The ankle kinesthesia in plantar/dorsal flexion of both exercise groups decreased, but the Tai Chi Group decreased more and sooner than the Brisk Walking Group. The training effects of Tai Chi exercise were retained but diminished during the detraining. The training effects of Brisk Walking exercise were not retained. The kinesthesia of ankle inversion and eversion remained unchanged after training. The results suggest that Tai Chi exercise is more effective in training ankle proprioception in plantar and dorsal flexion and in retaining the training effects compared with Brisk Walking exercise. [ABSTRACT FROM PUBLISHER]

Background The Six-Minute Walk Test (6MWT) has been used with clinical and healthy populations to assess functional capacity and cardiovascular fitness. The aim of this study was to determine the test-retest reliability of a modified-6MWT as well as concurrent validity of walk distance with peak oxygen uptake (VO2 peak). Method Participants were 13 adults (males = 7) with intellectual disability aged 18-44 years recruited from Special Olympics, and with no medical contraindications to exercise. The 6MWT was modified to include familiarisation, a 1:1 pacer, and encouragement every 15 s. Each participant performed the graded maximal treadmill test and the modified-6MWT twice. Results Test-retest reliability of the modified-6MWT was ICC = .98, and linear regression revealed that the modified- 6MWT distance was significantly related to VO2 peak ( R = .84, p < .001). Conclusions The modified-6MWT is easy to administer and score and shows acceptable validity and excellent reliability for assessing cardiovascular fitness in adults with intellectual disability. [ABSTRACT FROM AUTHOR]