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Geographical variables are usually not independent of each other. Hence, it is necessary to investigate the effect of interactions among explanatory variables on a response variable to characterize spatially enhanced or weakened relationships among all variables. The geographical detector (GD) model identifies zones for each explanatory variable, divides the study area into spatial units by overlapping these zones, and quantifies spatial associations as the power of interactive determinant (PID) between a response variable and explanatory variables. Consequently, the PID values depend upon the distributions of explanatory variables (i.e. spatial characteristics) and the subsequent division of spatial units out of these explanatory variables. This study has therefore proposed an Interactive Detector for Spatial Associations (IDSA) to optimize spatial division and improve PID. IDSA utilizes spatial autocorrelation of each explanatory variable and optimizes spatial units based on spatial fuzzy overlay to compute PID. We test the IDSA on both a simulation study and practical case that analyzes road deterioration in Australia. Results showed that the IDSA model could effectively assess the PID while existing GD overestimated PID. Hence, the IDSA improves the GD with refined spatial units based on explanatory variables to enhance their local spatial associations with a response variable. [ABSTRACT FROM AUTHOR]