1. Associations between grass pollen exposures in utero and in early life with food allergy in 12-month-old infants.
- Author
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Susanto, Nugroho Harry, Lowe, Adrian J, Salim, Agus, Koplin, Jennifer J., Tang, Mimi L. K., Suaini, Noor H. A., Ponsonby, Anne-Louise, Allen, Katrina J., Dharmage, Shyamali C., and Erbas, Bircan
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EGGS , *INFANT development , *CONFIDENCE intervals , *POLLEN , *PEANUTS , *DESCRIPTIVE statistics , *ODDS ratio , *ENVIRONMENTAL exposure , *FOOD allergy , *DISEASE risk factors , *CHILDREN , *FETUS - Abstract
Birth during pollen seasons may influence food allergy risk but no study has assessed pollen exposure. Using the HealthNuts population-based cohort of 5276 infants, we assessed grass pollen exposures, in utero and up to the first 6 months of life, on hen's egg, sesame and peanut allergy outcomes at 12 months. Cumulative pollen exposure in the first 7 days of life increased risk of peanut sensitization aMOR (adjusted multinomial odds ratio) = 1.21 (95% CI: 1.01–1.44). Exposure between first 4–6 months of life increased risk of hen's egg aMOR = 1.02 (95% CI: 1.004–1.04) and sensitization to all foods aMOR = 1.02 (95% CI: 1.003–1.04). Grass pollen exposure was associated with food challenge diagnosed food allergy, but only among infants with a maternal history of food allergy. Exposure to grass pollen in the intrauterine period and infancy may be important but more studies are needed to replicate these findings. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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