1. Fluorescent Determination of Ferric Ion in vitro with Carbon Quantum Dots Prepared by L-Arginine and Citric Acid.
- Author
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Zhang, Yuding, Xie, Mengyao, Ma, Gongcheng, Chen, Huajie, Li, Dai, Guan, Lijiao, Zhang, Xianfen, Wu, Jiyong, and Huang, Saipeng
- Subjects
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CITRIC acid , *QUANTUM dots , *IRON ions , *ARGININE , *STOKES shift , *BUFFER solutions , *DETECTION limit - Abstract
Ferric ion (Fe3+) serves as an essential and indispensable inorganic element in various biological process. Excess Fe3+ is harmful for biological systems and human health. Herein, highly sensitive carbon quantum dots (Fe-CQDs) for ferric ions were synthesized by a high-efficiency, one-step hydrothermal route utilizing L-arginine and citric acid. The prepared Fe-CQDs exhibited good water solubility, high photostability, and bright blue florescence with relatively high quantum yields (QYs) over 21.33% and a Stokes shift exceeding 100 nm. The functionalized Fe-CQDs offer rapid, sensitive, and selective recognition of Fe3+ with a linear relationship from 0.6 to 80 μM and a low detection limit of 0.2 μM. Moreover, the synthesized Fe-CQDs illustrated strong anti-interference properties in samples and buffer solutions. The developed sensor demonstrated high biocompatibility and was successfully applied for intracellular Fe3+ determination in SHSY5Y and HT22 cells, illustrating excellent imaging application. The present work provides a promising platform for the early clinical diagnosis of Fe3+-associated diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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