1. Mutations known from B-cell lymphoid malignancies are not found in CD34+ stem cells from patients with lymphoma.
- Author
-
Husby, Simon, Favero, Francesco, Rodriguez-Gonzalez, Francisco G., Sutton, Lesley A., Haastrup, Eva K., Ørskov, Andreas Due, Hansen, Jakob W., Arboe, Bente, Aslan, Derya, Clasen-Linde, Erik, Rahbek Gjerdrum, Lise Mette, Gørlev, Jette Sønderskov, Brown, Peter, Fischer-Nielsen, Anne, Rosenquist, Richard, Weischenfeldt, Joachim, and Grønbæk, Kirsten
- Subjects
- *
STEM cells , *LYMPHOMAS , *DIFFUSE large B-cell lymphomas , *HODGKIN'S disease , *MULTIPOTENT stem cells - Abstract
Future studies in this area are anticipated and will hopefully determine whether rare CD34 SP + sp stem cell clones with lymphoma mutations exists in patients with lymphoma, and whether they have an impact on clinical course and treatment response. Patients were included if they had a diagnosis of lymphoma, were intended to undergo ASCT, had a sufficient stem cell harvest and had at least one additional vial of their stem cell product available for research purposes. However, another possibility is that the methods used in this report (detection limit of VAF >2%, hence able to identify mutations in four out of a 100 CD34 SP + sp cells) are not sensitive enough to detect possible B-cell lymphoma CD34 SP + sp stem cells. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF