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We describe the formulation and application of an integrated general regional seismic loss assessment (RSLA) method for buildings in seismic regions. An efficient method for RSLA is valuable for engineers involved in city planning, risk management, and insurance dealings. In contrast to previously reported methods, the framework presented herein is hazard-based and utilizes a regional rapid seismic hazard deaggregation tool that allows regional assessment to be conducted more efficiently. The proposed technique is implemented as an example to assess general regional seismic loss in Los Angeles County for a ground motion hazard with 10% probability of exceedance in 50 years. [ABSTRACT FROM AUTHOR]