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Despite the potential of long duration earthquakes in subduction zones, little attention has been paid on seismic vulnerability assessment of highway bridges that are simultaneously undergoing prolonged corrosion deterioration. Consequently, this study presents a framework for considering the joint impact of ground motion duration and chloride-induced corrosion deterioration on the lifetime seismic vulnerability of aging highway bridge structures. The proposed framework is then applied to a representative case-study multi-span simply supported highway bridge located in subduction earthquake zone within Seattle, U.S.A. A detailed three-dimensional analytical models are first developed that account for the nonlinear behaviour of different bridge components, including experimentally validated column model capable of capturing cyclic degradation of force–deformation response. Suites of spectrally equivalent short and long duration ground motions are adopted followed by an incremental dynamic analysis-based framework for seismic fragility assessment. Deterministic seismic response assessment reveals a higher seismic demand on multiple bridge components under long duration ground motion record as compared to spectrally equivalent short duration record. Lastly, the bridge components and system fragility curves are developed considering modelling and deterioration uncertainties. Results reveal the significant vulnerability of bridge components and system under the joint impact of long duration earthquake shock and corrosion deterioration. [ABSTRACT FROM AUTHOR]