1. The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms.
- Author
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Musavi, Hadis, Abazari, Omid, Barartabar, Zeinab, Kalaki-Jouybari, Fatemeh, Hemmati-Dinarvand, Mohsen, Esmaeili, Parisa, and Mahjoub, Soleiman
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VITAMIN D , *COVID-19 pandemic , *COVID-19 , *CYTOKINE release syndrome , *AVIAN influenza , *SARS-CoV-2 - Abstract
In December 2019, a new infectious complication called CoronaVirus Infectious Disease-19, briefly COVID-19, caused by SARS-COV-2, is identified in Wuhan, China. It spread all over the world and became a pandemic. In many individuals who had suffered SARS-COV-2 infection, cytokine storm starts through cytokine overproduction and leads to Acute Respiratory Syndrome (ARS), organ failure, and death. According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1–7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk. Therefore, VitD intake may be beneficial for patients with SARS-COV-2 infection exposed to cytokine storm but do not suffer hypotension. In the present review, we have explained the effects of VitD on the renin-angiotensin system (RAS) function and angiotensin-converting enzyme2 (ACE2) expression. Furthermore, we have reviewed the biochemical and immunological effects of VitD on immune function in the underlying diseases and its role in the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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