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Mobility is essential in navigating familiar and unfamiliar environments. People with disability may experience vulnerability in navigating the external environment, when mobility is hindered by discomfort, commodification, or disorientation. Independent commute, choice, and control can be enhanced with appropriate aids, technology, and infrastructure. Self-determination can also be seen to enhance mobility through the realisation of strengths and limitations of the individual and the opportunity to act with self-regulation, in a way that responds to events in an empowered way. Utilising a critical incident technique, this qualitative study examines the enabling and disabling factors that impact self-determination of young adults with mobility disability in the context of their journey to work and explores the role digital technologies can play in this journey. Key findings related to the importance of mobility planning, transport options and communication in the journey to work are discussed. The importance of digital technologies is highlighted including the proposed features of digital enabling platforms. Points of Interest: Mobility is part of the journey to work experience that involves physical commute as well as the activities involved in planning and getting ready before commuting. Routine journeys take less planning and preparation than new journeys to work. For young adults with mobility disability, the journey to work is enhanced through mobility planning, transport option, policies and standards and communication. Self-determination of young adults with mobility disability can be enabled or disabled by a range of factors that significantly influence the journey to work experience. Digital technologies aid in supporting the planning and the commute experience for people with mobility disability. [ABSTRACT FROM AUTHOR]

Objective: To report the frequency of pathogenic SOD1 gene variants in a screening program in amyotrophic lateral sclerosis (ALS), and the clinical practice of transition to an expanded access program (EAP) of tofersen treatment. Methods: From October 2021 to February 2024, at 11 ALS centers in Germany genetic testing for SOD1, FUS, TARDBP, and C9orf72 was performed. Patients were offered to opt for notification either about all genetic variants or SOD1 variants relevant for tofersen therapy. The transition to the EAP with tofersen was assessed. Results: 1935 patients were screened (94.7% sporadic ALS). 48.8% (n = 928) opted for notification of treatment-relevant information. Genetic variants were found as follows: SOD1 (likely) pathogenic variants (class 4/5) 1.8% (n = 34), variants of unknown significance (class 3) 0.8% (n = 16), FUS (class 4/5) 0.9% (n = 17), TARDBP (class 4/5) 1.3% (n = 25), C9orf72 hexanucleotide repeat expansion 7.0% (n = 135). In SOD1-ALS (encompassing class 3–5 variants, n = 50), 68.0% (n = 34) reported a negative family history. 74.0% (n = 37) of SOD1-ALS patients – which represent 1.9% of all participants of the screening program – were transitioned to tofersen. Median duration from start of genetic testing to treatment was 94 days (57 to 295 days). Eight patients declined treatment whereas five individuals died before initiation of therapy. Conclusion: The finding of SOD1 variants in patients with a negative family history underscores the need for a broad genetic screening in ALS. In SOD1-ALS, the treatment option with tofersen was mostly utilized. The wide range in the transition time to tofersen calls for a SOD1-ALS management program. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to compare the efficacy of royal jelly (RJ) and its major fatty acid 10-hydroxy-2-decenoic acid (10-HDA) on ischemic stroke-related pathologies using histological and molecular approaches. Methods: Male rats were subjected to middle cerebral artery occlusion (MCAo) to induce ischemic stroke and were supplemented daily with either vehicle (control group), RJ or 10-HDA for 7 days starting on the day of surgery. On the eighth day, rats were sacrificed and brain tissue and blood samples were obtained to analyze brain infarct volume, DNA damage as well as apoptotic, inflammatory and epigenetic parameters. Results: Both RJ and 10-HDA supplementation significantly reduced brain infarction and decreased weight loss when compared to control animals. These effects were associated with reduced levels of active caspase-3 and PARP-1 and increased levels of acetyl-histone H3 and H4. Although both RJ and 10-HDA treatments significantly increased acetyl-histone H3 levels, the effect of RJ was more potent than that of 10-HDA. RJ and 10-HDA supplementation also alleviated DNA damage by significantly reducing tail length, tail intensity and tail moment in brain tissue and peripheral lymphocytes, except for the RJ treatment which tended to reduce tail moment in lymphocytes without statistical significance. Conclusions: Our findings suggest that neuroprotective effects of RJ in experimental stroke can mostly be attributed to 10-HDA. [ABSTRACT FROM AUTHOR]

The paternal attachment that fathers establish with their infants during pregnancy forms the basis of postnatal relationships and strongly affects the dynamics within the family. The present study was conducted to determine the effects of fathers' gender role attitudes, marital adjustment, and maternal attachment on prenatal paternal attachment in the third trimester in Turkiye. This descriptive cross-sectional study was conducted between January and November 2023 and included 255 fathers whose partner was between 28 and 40 weeks old and who had a healthy pregnancy and their partners in the obstetric outpatient clinic of one of the most advanced university hospitals. The relevant data for the study were collected via the "Descriptive Characteristics Form," "Gender Role Attitudes Scale," "Marital Adjustment Scale," "Prenatal Attachment Inventory," and "Paternal Antenatal Attachment Scale." The descriptive characteristics data form was completed by the fathers, the gender role attitudes scale, the marital adjustment scale, and the prenatal attachment scale were completed by the fathers, and the prenatal attachment inventory was completed by their partners. Descriptive statistics, independent t-tests, one-way ANOVA, the Bonferroni correction, post hoc tests, and multiple linear regression were used to analyze the data. Among the descriptive characteristics evaluated, paternal age (p =.075) and perceived economic status (p =.216) were not revealed to have any effect on prenatal paternal attachment. Gender role attitudes (p =.238) and maternal attachment (p =.178) also had no effect on paternal attachment. Marital adjustment affected prenatal paternal attachment (p =.000). Since marital adjustment was found to be effective on paternal attachment in this study, it is recommended that this variable be integrated into prenatal care practices. [ABSTRACT FROM AUTHOR]

This article presents the bending behavior of carbon nanotubes (CNTs) based on doublet mechanics (DM) and Euler–Bernoulli beam theory to analyze how deflection changes with higher-order boundary conditions and the coupling, which have not been previously investigated. The governing equations and associated boundary conditions are obtained using the principle of minimum potential. Numerical solutions show an important effect of higher-order boundary conditions on the deflection of cantilever CNTs, unlike simply supported CNTs. A paradox in which DM shows a stiffening behavior for cantilever CNTs is resolved using higher-order boundary conditions. The coupling significantly effects the bending behavior of armchair CNTs. [ABSTRACT FROM AUTHOR]

The ethanol-soluble (6E,6'E)-6,6'-(1,2-phenylenebis(azan-1-yl-1-ylidene))dihexane-1,2,3,4,5-pentaol (LISPDA) and (E)-6-(2-hydroxyphenylimino)hexane-1,2,3,4,5-pentaol (LISAP) were investigated in this study. Condensation of 1,2-phenylenediamine and 2-aminophenol with 2,3,4,5,6-pentahydroxyhexanal (GL) in the presence of weak acid as a catalyst under mono-mode microwave heating yielded the glucose-Schiff base product. A one-pot microwave-assisted reaction in a short reaction time was required to complete the imine condensation reaction with 90% yield and no byproducts. The molecular structures of these were discovered to be in an extended conformation, with the aromatic moiety coplanar with that of the imine bond and the imine bond exhibiting trans-geometry. Schiff base metal complexes were successfully synthesized by combining 1,2-phenylenediamine and 2-aminophenol with D-glucose and Co(II), Ni(II), and Cu(II). Elemental analysis, magnetic susceptibility, thermal analysis, and electronic and infrared spectral studies were used to determine the structural assessment of ML2 complexes. [ABSTRACT FROM AUTHOR]

Despite efforts to find effective drugs for sepsis-associated acute kidney injury (SA-AKI), mortality rates in patients with SA-AKI have not decreased. Our study evaluated the protective effects of isoflavone osajin (OSJ) on SA-AKI in rats by targeting inflammation, oxidative stress, and apoptosis, which represent the cornerstones in the pathophysiological mechanism of SA-AKI. Polymicrobial sepsis was induced in rats via the cecal ligation and puncture (CLP) technique. Markers of oxidative stress were evaluated in kidney tissues using biochemical methods. The expression of interleukin-33 (IL-33), 8-hydroxydeoxyguanosine (8-OHdG), caspase-3, and kidney injury molecule-1 (KIM-1) was evaluated as indicators of inflammation, DNA damage, apoptosis, and SA-AKI respectively in the kidney tissues using immunohistochemical and immunofluorescent detection methods. The CLP technique significantly (p < 0.001) increased lipid peroxidation (LPO) levels and significantly (p < 0.001) decreased the activities of superoxide dismutase and catalase in kidney tissues. In the renal tissues, strong expression of IL-33, 8-OHdG, caspase-3, and KIM-1 was observed with severe degeneration and necrosis in the tubular epithelium and intense interstitial nephritis. In contrast, the administration of OSJ significantly (p < 0.001) reduced the level of LPO, markedly improved biomarkers of antioxidant status, decreased the levels of serum creatinine and urea, lowered the expression of IL-33, 8-OHdG, caspase-3, and KIM-1 and alleviated changes in renal histopathology. A promising binding score was found via a molecular docking investigation of the OSJ-binding mode with mouse IL-33 (PDB Code: 5VI4). Therefore, OSJ protects against SA-AKI by suppressing the IL-33/LPO/8-OHdG/caspase-3 pathway and improving the antioxidant system. [ABSTRACT FROM AUTHOR]

Objectives: Neuromyelitis optica (NMO) is an inflammatory, autoimmune and demyelinating disease of the central nervous system and is often characterized by attacks of severe optic neuritis and long segment myelitis. Identifying the disease-specific pathogenic anti-AQP4 autoantibody in NMOSD has allowed the development of highly effective disease-modifying drugs in the treatment phase. Eculizumab is a humanized antibody that binds to complement C5 and inhibits the formation of the C5b-induced membrane attack complex. It is approved for treating many diseases in which tissue damage is accompanied by complement (such as neuromyelitis optica, myasthenia gravis, autoimmune hemolytic anemia and paroxysmal hemoglobinuria). Methods: We present a patient diagnosed with NMO who developed possible drug-induced liver injury three months after the start of eculizumab treatment. Result: After discontinuing eculizumab treatment, liver function tests gradually regressed in a month. Conclusions: Eculizumab-associated hepatotoxicity is a previously unreported adverse event in NMOSD patients. Therefore, patients should be monitored for liver function tests during eculizumab treatment, and care should be taken for hepatotoxicity. If hepatotoxicity is detected while under eculizumab treatment, patients should be investigated for other drug use, complementary food supplementation, or possible autoimmune hepatitis, and other potential causes should be excluded. [ABSTRACT FROM AUTHOR]

Conventional wisdom suggests that social media, especially when used by authoritarian powers with nefarious aims, leaves citizens of democratic countries vulnerable to psychological influence campaigns. But such concerns overlook predispositions among recipients of false claims to reject (or to endorse) conspiratorial narratives. Analyzing responses from a survey fielded in 19 countries, we find that it is a preexisting conspiracy outlook at the individual level, more so than media diets, which consistently predicts rating Russia's pretenses for the invasion as more accurate. In all countries, individuals who view the world in general with a conspiratorial mindset are more likely to believe war-related disinformation. Receiving news via YouTube, Facebook, or TikTok is also associated with greater belief in Russian narratives justifying the invasion in several countries, but these relationships are weaker compared to those observed for conspiracy thinking. Without downplaying a potential positive role for media interventions, the findings highlight the importance of a deeper understanding of the underlying causes of conspiratorial thinking. [ABSTRACT FROM AUTHOR]

Background: First responders (i.e. police and ambulance staff) have increasingly become part of the mental health care system, often being the first port of call for those experiencing a crisis. Despite their frequent involvement in supporting those with mental health problems, there is evidence that mental health stigma is high amongst first responders. Aims: The aim of the present study was to evaluate a brief training video aimed at reducing mental health stigma amongst first responders. Methods: First responders watched a training video based on the cognitive behavioural model of mental health stigma, and involved contributions from people with lived experience, and first responders. Measures of mental health stigma were collected before and after viewing the training. Results: The training video produced small but significant improvements in mental health stigma, and these effects did not differ between police and ambulance staff. We were unable to determine what psychological constructs mediated this change in stigma. The feedback on the training video was generally positive, but also indicated some key areas for future development. Conclusions: The present study provides encouraging evidence that levels of mental health stigma can be improved using a resource-light training intervention. [ABSTRACT FROM AUTHOR]

4-Nitrobenzaldehyde (C7H5NO3) (4NB) single crystals were obtained by slow evaporation technique. Single crystals were made paramagnetic by irradiation with a 60Co-gamma rays. Electron Paramagnetic Resonance (EPR) Spectroscopy method was used to detect the radiation damage center formed in the single crystals. As a result of temperature scanning of EPR spectra at different temperatures between 120 and 470 K, it was found to be independent of temperature. That's why the EPR study was done only at 300 K. The radiation effect caused the formation of the 4NB anion radical in the 4NB single crystal. All the protons in the structure created hyperfine structure splittings. The principal values of the hyperfine structure constants resulting from the interaction of the unpaired electron with protons, the principal values of the g-tensor and their direction cosines were calculated. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to examine and compare the effects of intravitreal bevacizumab injection (IVB) at subfoveal 1500 micron (μm) and submacular 6000 μm in patients with diabetic macular edema (DME). Methods: Fifty eyes of 45 patients with DME who completed six doses of IVB were included in the study group, and 50 eyes of 42 patients who had diabetic retinopathy (DR) but did not receive any treatment were included in the control group. Central macular thickness (CMT), central choroidal thickness (CCT), subfoveal and total choroidal area (TCA), and choroidal vascular index (CVI) were calculated and their changes at zero, three and six months were evaluated. Results: At baseline, CVI was significantly lower in both the subfoveal and total macular areas in the study group (p = 0.004, p = 0.003). In the study group, a significant decrease was observed in CVI between zero and six months in the subfoveal area (p = 0.001). In the submacular area, the decrease in CVI in the study group was significant between zero to three months and zero to six months. There was moderate correlation between measurements of CVI in the subfoveal and total macular areas (r = 0.66, p < 0.001). Conclusion: These findings indicate that intravitreal bevacizumab injection reduces the CVI and the effects of intravitreal anti-VEGF on CVI emerge earlier and more prominently in the submacular 6000 µm area. [ABSTRACT FROM AUTHOR]

Tenofovir alafenamide (TAF) is a new drug from the nucleotide reverse transcriptase inhibitor group approved for the treatment of chronic Hepatitis B in 2016. With this study, we aimed to test whether possible cellular toxicity can be reduced by controlled drug release as a result of loading with chitosan nanoparticles (CHS). We investigated the genotoxic and mitotoxic effects of 45 µM TAF-loaded CHS and TAF-only on HepG2 cells by micronucleus (MN), comet assay, determination of mtDNA quantification, mitochondrial membrane potential (ΔΨm), and ROS levels. Additionally, we compared the samples by RNAseq analyses to reveal the transcriptional responses to each regimen. In terms of genotoxic tests, although MN and comet were found higher in all experimental treatment conditions, the encapsulation of CHS reduced the genotoxicity of TAF. MtDNA level was found to be lower in the TAF treatment, whereas it was higher in CHS and CHS-TAF treatments. The TAF-loaded CHS and TAF treatments had an impaired ΔΨm value. Cellular ROS levels were higher in all treatment conditions. According to the analyses of gene expression patterns; CHS-only changed the expression of relatively few genes (187 genes), while TAF changed the expression of the 1974 genes and TAF-loaded CHS changed the expression of 734 genes. Considering the gene expression numbers, CHS encapsulation of TAF significantly reduced the number of genes that were differentially expressed by TAF-only. Overall, we observed that TAF has genotoxic and mitotoxic effects on HepG2 cells, and upon encapsulation with CHS, its genotoxic and mitotoxic effects were decreased. [ABSTRACT FROM AUTHOR]

Nuclear applications are being increasingly used in various fields, necessitating studies to protect from radiation hazards and their effects. In this study, five different chemical structures of pyrazolo [3,4-b] pyridine derivatives were synthesized. The gamma and neutron radiation protective abilities of these samples were determined and demonstrated their potential use as ingredients in radioprotective drugs. Gamma radiation absorption parameters were calculated both theoretical and experimental. Important attenuation parameters for fast neutrons (4.5 MeV energy radiation) were figured out using the Monte Carlo simulation Geant4 code. Additionally, experimental dose rates were measured for each sample and compared to those of Paraffin and high-density polyethylene, an organic substance. Besides, Ames/Salmonella test system was aimed to detecting genotoxicity features of pyrazolo pyridine derivatives. All results demonstrated that each sample possesses both gamma and neutron radiation attenuation capabilities. It was determined that sample PPC4 (C20H14BrN5) exhibited the highest gamma radiation attenuation capacity among all samples, while sample PPC2 (C22H20N6) displayed an excellent neutron stopping capacity. The genotoxic properties of pyrazolo[3,4-b] pyridine derivatives were examined using the Ames/Salmonella test, and as a result, it was determined that these substances did not exhibit genotoxic effects at test doses up to 5 mM. All obtained results indicate that all PPC (pyrazolo[3,4-b] pyridine derivatives) samples do not possess a toxic effect, and they can be utilized as an active substance for the development of a drug or cream with protective properties against both gamma and neutron radiations. [ABSTRACT FROM AUTHOR]

Identity Salience is a common construct within social identity research. However, researchers note that it is poorly defined and inconsistently operationalized. We posit that identity salience comprises two elements: chronic (perpetually thinking about the identity) and contextual (only thinking about the identity when prompted) salience. We present evidence for this claim through the development and validation of the dual-dimensional Identity Salience Questionnaire (ISQ). Studies 1-2 (Ns=414; 1,069) provide exploratory and confirmatory factor analytic evidence of the ISQ among LGBTIQA+ participants. Study 2 also provides evidence of measurement invariance, convergent, predictive, and discriminant validity, and internal reliability. Study 3 (N=318) indicates strong test-retest reliability. Study 4 (N=107 social psychologists) confirms the ISQ's content validity. Future research for the ISQ is discussed. [ABSTRACT FROM AUTHOR]

Objectives: The aim was to construct validity and reliability of the Hearing Implant Sound Quality Index Questionnaire (HISQUI19) in Turkish. Methods: This study was a methodologic study to validate HISQUI19 in Turkish. The study included 62 cochlear implant users. Guttman's split half-coefficient and Cronbach's alpha tests were used for construct validity and internal consistency. Pearson correlation test was used to assess the relationship of the HISQUI19 total score to the SSQ49 scales for CI users and to show test – retest reliability. Results: The Cronbach's α value was 0.94 overall score with high internal consistency (Guttman's split-half-coefficient: 0.912). Test-retest reliability results showed high repeatability and consistency of the measure across time (r = 0.708; P = 0.002). Support for conducting factor analysis was provided by the KMO test, with a value of 0.876, which is 'great'. Discussion: Subjective evaluation of cochlear implant users' daily life experiences is a useful tool to reveal the auditory benefits of cochlear implant usage. Conclusion: Turkish version of the HISQUI19 is a reliable and valid assessment tool for adults with CIs. This questionnaire provides clinicians with a valuable, reliable, and valid tool for determining the subjective benefit of CI for patients. [ABSTRACT FROM AUTHOR]

The prevalence of post-COVID headaches is not low. The eye can be affected by this infection, but it is not clear yet what the relationship is between persistent headaches and the thickness of the retinal nerve fiber layer (RNFL) after COVID-19 infection this study aims to investigate the relationship between these subjects. In this retrospective study, in patients who have had a persistent headache, SD-OCT analysis of RNFL was obtained, and RNLF thickness values before and after COVID-19 infection were analyzed. A total of 26 eyes from 13 patients (nine (69.2%) females, four (30.8%) males) with persistent headaches after COVID-19 infection were studied. The average age was 47,35 years for females and 63 years for males. The mean RNFL thickness of both eyes between before and after COVID-19 infection decreased, which was statistically significant. In this study, a correlation between headache and changes in RNLF after COVID-19 infection was found. It may have wider ramifications to look into the COVID-19-associated headache phenotype of people with a history of migraines, contributing to a more comprehensive understanding of migraine pathogenesis. This relationship can provide further insight into this infection. [ABSTRACT FROM AUTHOR]

Objectives: The aim was to construct validity and reliability of the Hearing Implant Sound Quality Index Questionnaire (HISQUI19) in Turkish. Methods: This study was a methodologic study to validate HISQUI19 in Turkish. The study included 62 cochlear implant users. Guttman's split half-coefficient and Cronbach's alpha tests were used for construct validity and internal consistency. Pearson correlation test was used to assess the relationship of the HISQUI19 total score to the SSQ49 scales for CI users and to show test – retest reliability. Results: The Cronbach's α value was 0.94 overall score with high internal consistency (Guttman's split-half-coefficient: 0.912). Test-retest reliability results showed high repeatability and consistency of the measure across time (r = 0.708; P = 0.002). Support for conducting factor analysis was provided by the KMO test, with a value of 0.876, which is 'great'. Discussion: Subjective evaluation of cochlear implant users' daily life experiences is a useful tool to reveal the auditory benefits of cochlear implant usage. Conclusion: Turkish version of the HISQUI19 is a reliable and valid assessment tool for adults with CIs. This questionnaire provides clinicians with a valuable, reliable, and valid tool for determining the subjective benefit of CI for patients. [ABSTRACT FROM AUTHOR]

AbstractIntroduction: We investigated the role of E-cadherin and Ber-EP4 in tubal pregnancy by comparing their expressions in epithelial and trophoblastic cells both in ectopic tubal and intrauterine pregnancies. Methods: The Formalin-fixed paraffin embedded blocks of 17 intrauterine and 17 tubal pregnancies were immunohistochemically stained with E-cadherin and Ber-EP4. Results: E-cadherin was expressed in the epithelium, villous and extravillous trophoblast in tubal and intrauterine pregnancies but not in the syncytiotrophoblast. The staining intensity was lower in the extra-villous trophoblast in tubal ectopic pregnancies compared with intrauterine pregnancies. Ber-EP4 was expressed in the epithelium of tubal and intrauterine pregnancies and only in villous cytotrophoblast. The intensity of staining in tubal pregnancy was higher than in intrauterine pregnancy. Discussion: The loss of E-cadherin expression in extra-villous trophoblast and increased expression of Ber-EP4 in the villous cytotrophoblast may play a role in the formation of tubal pregnancy by allowing the blastocyst to attach to the tubal epithelium. [ABSTRACT FROM AUTHOR]

Lenalidomide and rituximab (R2) is an effective frontline treatment for patients with indolent B-cell non-Hodgkin lymphoma (iNHL). We investigated the safety and efficacy of addition of the proteasome inhibitor ixazomib to R2 for treatment of iNHL through a phase I/II clinical trial for high-risk patients. Twenty patients were enrolled, 18 were treated. The target dose of ixazomib 4 mg weekly was achieved during dose escalation. The most common treatment-related adverse events (AEs) were low grade gastrointestinal, rash, neuropathy, and myalgia/arthralgia. There were 33% grade 2 and 17% grade 3 infections. With median follow-up of 5.2 years, four patients discontinued treatment due to lymphoma progression. Best overall response rate (ORR) was 61.2% [55.6% CR, 5.6% PR): 22.2% had stable disease and 16.7% had disease progression. Kaplan-Meier estimates of progression free and overall survival (OS) were 73% and 87% at 36 months, respectively. R2 can safely be combined with ixazomib for treatment-naïve iNHL patients. [ABSTRACT FROM AUTHOR]

To determine the structure and properties of corneal endothelial cells in children and adolescents with ADHD who received methylphenidate treatment at least six months. The prospective, observational study included 33 eyes of 33 patients diagnosed with ADHD who received methylphenidate treatment for at least six months, 33 eyes of 33 patients newly diagnosed with ADHD who did not start medication treatment, and 33 eyes of 33 healthy individuals. Average cell density, coefficient of variation, maximum cell area, normal cell area, minimum cell area, average cell area, and hexagonality ratio values were evaluated by non-contact specular microscopy. The parameters recorded in all three groups were compared. The average age of children in the ADHD + MPH, ADHD, and control groups is 9 ± 1.7, 8.9 ± 2.3, and 8.9 ± 1.8 years, respectively. (p > 0.05) The average MPH treatment dose is 0.94 ± 0.19 mg/kg, the average daily MPH intake is 34.12 ± 14.04 mg, and the average duration of use of MPH is 24.03 ± 12.46 months. Central corneal thickness (CCT) was measured as an average of 540.45 ± 31.23 in the ADHD + MPH group, 540.61 ± 29.69 in the ADHD group, and 546.58 ± 27.72 in the control group. (p = 0.499) The average coefficient of variation (CV) values were measured as 25.48 ± 4.22 in the ADHD + MPH group, 26.12 ± 3.48 in the ADHD group, and 26.12 ± 3.64 in the control group. (p = 0.491) The average hexagonality ratio (%) (HEX) values were measured as 69.45 ± 8.41 in the ADHD + MPH group, 68.21 ± 6.82 in the ADHD group, and 68.91 ± 7.97 in the control group. (p = 0.892) No statistically significant difference was observed between all three groups in terms of all parameters. Methylphenidate treatment administered for at least six months with a diagnosis of ADHD did not have a toxic effect on the corneal endothelium. [ABSTRACT FROM AUTHOR]

The ventromedial prefrontal cortex (vmPFC) and the ventral striatum are brain regions that are critical for the reward circuit and the maintenance of pleasure. The relationship between these regions and alcohol use disorder has been investigated in the literature in a variety of ways. In this context, it is aimed to determine whether there are structural changes in the vmPFC and ventral striatum regions in patients with alcohol use disorder (AUD) compared to healthy control subjects. Fifteen patients with AUD according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5) diagnostic criteria and seventeen healthy controls participated in our study. The volumes of the vmPFC and ventral striatum were measured in subjects. The mean volumes of both sides of the vmPFC were significantly smaller in patients with AUD than those in the healthy control group whereas both sides of ventral striatum volumes were larger. This study is one of the few to examine structural changes in the vmPFC and ventral striatum together in patients with ACD. Although the contribution of the positive findings to the literature is important, more comprehensive studies are needed to strengthen the existing findings. [ABSTRACT FROM AUTHOR]

Global nations strategically aim to embrace net-zero transformations that warrant active involvement from tourists to drive radical change (i.e. readiness for net-zero tourism) at host destinations. The present study aimed to clarify tourists' intentional readiness for net-zero tourism by using the costly-signaling theory and the knowledge-attitude-behavior model. The findings based on a representative sample (N = 430) of tourists in Turkiye demonstrated that subjective environmental knowledge and eco-literacy significantly boost intentional readiness for net-zero tourism. This effect intensifies when net-zero practices are perceived as conspicuous. Interestingly, greenwashing perception negatively moderated the influence of subjective environmental knowledge on intentional readiness for net-zero tourism. [ABSTRACT FROM AUTHOR]

This study was carried out to transform the hydrolyzed pea protein into a pharmaceutical tablet form by masking methylprednisolone. This study provides some crucial contributions in showing how functional excipients such as pea protein, which are generally used in food industries, can be used in pharmaceutical product formulations and their effects. Methylprednisolone was formulated using spray drying technology. Design Expert Software (Version 13) was used for the statistical analysis. The in vitro cytotoxic effects for NIH/3T3 mouse fibroblast cells were investigated by XTT cell viability assay. HPLC was used to analyze the Caco-2 permeability studies and dissolution tests. The optimum formulation was evaluated against the reference product by performing cytotoxicity and cell permeability studies. According to our test results, Papp (apparent permeability) values of Methylprednisolone were measured around 3 × 10-6 cm/s and Fa (fraction absorbed) values around 30%. These data indicate that Methylprednisolone HCl has 'moderate permeability' and our study confirmed that it could have belonged to BCS Class II-IV since both low solubility and moderate permeability. The findings offer valuable information to guide and inform the use of pea protein in pharmaceutical formulations. Significant effects on methylprednisolone tablet formulation designed with the philosophy of quality by design (QbD) of pea protein have been demonstrated by both in vitro and cell studies. [ABSTRACT FROM AUTHOR]

In the present work, the electronic structure, elastic parameters, density of states (partial and total), optical properties, and charge density of ZrB5 (B = Se, Te) have been investigated by means of first principles calculations. The generalized gradient approximation has been used for modeling the exchange-correlation effects. It has been observed that the calculated lattice parameter values are in agreement with the values in the literature. The second-order elastic constants were calculated, and the other related quantities have also been estimated. The electronic band structures and the partial density of states corresponding to these band structures of ZrSe5 and ZrTe5 are examined, and it is understood that ZrTe5 and ZrSe5 are narrow band semiconductors or semimetals. Finally, the electron energy loss function (ELS) spectra and charge density of ZrB5 are calculated and interpreted. [ABSTRACT FROM AUTHOR]

Research has demonstrated concussion likely causes autonomic dysfunction leading to exercise intolerance. To measure improvement in exercise intolerance due to suspected dysautonomia associated with protracted concussion recovery, using objective measurements on a Buffalo Concussion Treadmill Test (BCTT) following participation in a prescribed exercise program. This is a retrospective cohort study of 101 patient charts post-concussion. Exercise intolerance was assessed using a BCTT to identify suspected dysautonomia and an exercise prescription was provided using guidelines for treating concussion-associated exercise intolerance. Patients without symptom improvement and/or inability to achieve 80–85% of age-expected maximum heart rate (HR) without symptom exacerbation received a repeat BCTT. Twelve patient charts met inclusion criteria and were included in data analysis. There were significant improvements from pre-intervention to post-intervention testing in: maximum BCTT stage mean scores (p =.02); maximum HR mean scores (p =.01); prescription HR (RxHR) mean scores (p =.01); and HR delta (HR $$\delta $$ δ) mean scores (p =.00). Maximum stage, HR threshold, RxHR, and newly identified HR delta (HR $$\delta $$ δ) are potential objective measurements of progress for dysautonomia treatment post-concussion. Future studies are indicated to create a tailored protocol in the management of protracted concussion-associated dysautonomia. [ABSTRACT FROM AUTHOR]

This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis. [ABSTRACT FROM AUTHOR]

There is limited data about the neurological effects of Covid-19 in infected patients. In this report, we present 2 LETM cases that are possibly associated with Covid-19 infection. Here, we present 2 cases that subsequently developed LETM following Covid-19 infection. The first case presented a finding of tetraparesis prominent in the lower extremities that started ten days after the Covid-19 infection. The second patient was admitted with paraparesis and urinary-stool retention on the 12th day from the onset of symptoms of Covid-19 infection. In these 2 cases, LETM developing following Covid'19 infection was associated with Covid-19 infection. Although Covid-19 PCR was negative in the CSF of both patients, the Covid-19 PCR test was positive in the samples taken from the oropharynx. The mechanism of LETM caused by Covid-19 infection is not clearly known. However, both direct infection of the spinal cord and excessive inflammatory response to primary Covid-19 infection may cause spinal cord damage. Therefore, possible Covid-19-associated myelitis should be kept in mind in cases of long segment transverse myelitis grouped under the title of NMOSD and without any etiological factor. [ABSTRACT FROM AUTHOR]

Fatigue life assessment of metal additive manufacturing (AM) products has remained challenging due to the uncertainty of as–built defects, heterogeneity of the microstructure, and residual stress. In the past few years, many works have been conducted to develop models in order to predict fatigue life of metal AM samples by considering the existence of AM inherent defects. This review paper addresses the main issues regarding fatigue assessment of metal AM parts by considering the effect of defects and post processing strategies. Mechanisms that are contributing to the failure of metal AM samples are categorized and discussed in detail. Several modelling approaches exist in the case of fatigue life prediction. The common fatigue models that are compatible with AM properties are thoroughly explained by discussing the previous works and highlighting their major conclusions. In addition, the use of machine learning is identified as the future of metal AM fatigue life assessment due to their high performance. The main challenge of today's fatigue and fracture community was identified as the fatigue life estimation of complex geometries with the presence of different types of defects, anisotropic microstructure, and complex state of residual stress. This work proposes the available approaches to tackle this challenge. [ABSTRACT FROM AUTHOR]

CEE countries faced significant political, economic, social, and technological transformations over the last four decades. Democratic processes, after relative stabilization, tremble again around polarizing values, populist leaders, or nationalistic ideologies. Online communication, especially social media platforms, play a vital role in shaping how citizens interact with the state, political actors, media, and other citizens. The collection of manuscripts focuses on some of the challenges democratic institutions in the region face, in transforming and sustaining civil society and attempts to capture how the digital media environments mitigate or exacerbate those challenges. Included manuscripts focus on the role that online platforms play in the satisfaction with democracy in the CEE region, the interactions between journalists and political actors, the strategic media coverage of elections, affective polarization and political antagonism, and discursive attempts to discourage young people from civic engagement. [ABSTRACT FROM AUTHOR]

The effects of 1% biofilm (ParkaTM) treatment regimes, initiated three (biofilm-3), two (biofilm-2), and one week (biofilm-1) prior to the commercial harvest, on fruit quality traits during the postharvest storage stage were investigated in this study. The treated fruit were stored at 0 ± 0.5°C and 90 ± 5% RH for 21 days. The application of biofilm treatments had no discernible effect on weight loss. In fact, biofilm-1 was found to have the opposite effect, resulting in increased weight loss. Respiration rates of biofilm-treated fruit were generally higher than those of control. Firmness of the biofilm treatments was higher than that of the control, both at harvest and during storage. Red coloration of the fruit was delayed by the biofilm treatments. Biofilm treatments caused a significant increase in the SSC of the fruit. The acidity of the control was lower than that of the biofilm treatments from the time of harvest until the 14th d. At the end of 21 d, there was no significant difference in acidity between the treatments. The effects of the treatments on vitamin C differed according to the date of measurement. At the end of storage, vitamin C was higher in fruit treated with biofilm-1 and biofilm-2. All biofilm treatments caused a significant increase in total phenolics, total flavonoids, anthocyanin content and antioxidant activity of the fruit, which was more evident in the biofilm-1 treatment. The results showed that biofilm treatments were more effective in maintaining fruit firmness and bioactive compounds during storage. [ABSTRACT FROM AUTHOR]

Data suggests that the majority of citizens in various countries came across 'fake news' during the COVID-19 pandemic. We test the relationship between perceived prevalence of misinformation and people's worries about COVID-19. In Study 1, analyses of a survey across 17 countries indicate a positive association: perceptions of high prevalence of misinformation are correlated with high worries about COVID-19. However, the relationship is weaker in countries with higher levels of case-fatality ratios, and independent from the actual amount of misinformation per country. Study 2 replicates the relationship using experimental data. Furthermore, Study 2 demonstrates the underlying mechanism, that is, perceived prevalence of misinformation fosters the belief that COVID-19 is spiralling out of control, which in turn, increases worries. Our findings suggest that perceived prevalence of misinformation can have significant psychological effects, even though audience members reject the information as being false. [ABSTRACT FROM AUTHOR]

Several studies have reported that inservice and preservice teachers hold narrow and stereotypical perceptions of engineer and engineering. However, only a few studies attempted to examine interventions which improve their perceptions. This study aimed to explore the preservice science teachers' (PSTs) perceptions of engineer and engineering, and the impact of science, technology, engineering, and mathematics (STEM) education on their perceptions. An instructional design was developed based on STEM education and implemented for 10 weeks after a two-week training program provided to the PSTs on STEM Education and Engineering Design Process (EDP). Data were collected with sophomore PSTs (N = 51) using the Draw an Engineer (DAE) test before and after the implementation and analyzed using the revised checklist for the DAE that consists of five categories: (1) the appearance of engineers, (2) type of engineering, (3) location, (4) actions, and (5) other people and objects. The results indicated that the PSTs hold undesirable stereotypical understandings such that engineering is a masculine profession that involves working individually. Besides, some PSTs tend to link engineering with physical labor such as building and operating a machine or vehicle before the implementation. The results also provided evidence of improvement in the PSTs' narrow and stereotypical perceptions of engineer and engineering, notably in terms of gender of engineer, the variety of types of engineering, actions, and interaction with other people after the implementation. This study reveals that PSTs need support and training to enhance their perceptions of engineer and engineering. STEM education may be considered a promising approach to improve their understanding of engineering and help them overcome their stereotypical perceptions of what engineering is and what engineers do. [ABSTRACT FROM AUTHOR]

Tacrolimus (TAC) is a potent and well-tolerated immunosuppressive drug, but serious side effects including nephrotoxicity and hepatotoxicity have been reported. Ursodeoxycholic acid (UDCA) and resveratrol (RSV) exhibit hepatoprotective effects in liver diseases. We investigated the hepatoprotective effect of UDCA and RSV against TAC induced hepatotoxicity. We divided 40 male rats into five equal groups: A) control group, B) TAC group, C) TAC + UDCA group, D) TAC + RSV group, E) TAC + UDCA + RSV group. We administered 0.5 mg/kg TAC once daily, 25 mg/kg UDCA twice daily and 10 mg/kg RSV once daily. The drugs in the experimental groups were given by gavage from the first day of the study and continued for 21 days. Histopathologic and biochemical analyses were performed on day 22. In group B, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6), total oxidative status (TOS) and malondialdehyde (MDA) levels were higher compared to group A, and catalase (CAT), superoxide dismutase (SOD) levels and total antioxidant status (TAS) were lower compared to group A. Severe cellular swelling, degeneration and focal necrosis were more evident in group B than in groups C–E. Histopathological improvement was observed in groups C–E, where UDCA and RSV were combined, compared to group B. We found that UDCA and RSV, together or separately, protected the liver against oxidative stress damage caused by TAC. [ABSTRACT FROM AUTHOR]

Using a convergent parallel mixed methods design, the present study examined children's screen time and social behaviors through parents' perceptions. The participants were 113 children and their parents for the quantitative strand and 42 randomly selected parents for the qualitative strand of the study. Parents reported on children's social behaviors and screen time in the quantitative strand, and semi-structured interviews were conducted with parents in the qualitative strand of the study. Quantitative data were analyzed using cluster analyses, and qualitative data were analyzed using an open-coding system; following that, the quantitative and qualitative results were collaboratively discussed. Using cluster analyses, children were categorized into two groups (positive and relatively social negative behaviors) that reflect their social behaviors during peer play context. Qualitative analyses identified parents' perceptions of their children's social behavior and screen time. Accordingly, qualitative results consistently supported the two groups categorized in the quantitative strand. In addition, parents' use of screen-related strategies was related to children's positive social behaviors. Findings from the current study suggest that considering children's engagement with screen time may contribute to a greater understanding of children's social behaviors. [ABSTRACT FROM AUTHOR]

This research was conducted to examine the relationship of perceived social support, personality traits, and self-esteem of pregnant women with fear of childbirth. The study was performed between April 15, 2016 and May 15, 2016 using face-to-face interviews with 128 pregnant women who were at 28–40 weeks of pregnancy. A negative correlation between the fear of childbirth and the levels of social support perceived by pregnant women and a positive correlation between the fear of childbirth and self-esteem were observed. Furthermore, a negative correlation between the fear of childbirth and extraversion, self-discipline, and openness to development and a positive correlation between the fear of childbirth and neurotic personality traits were noted. Hence, we propose that social support status, personality traits, and self-esteem of pregnant women should be viewed as risk factors for the fear of childbirth. [ABSTRACT FROM AUTHOR]

In this prospective case control study, relationship of detailed cerebellar volumetric data and cognition in patients with multiple sclerosis considering falling status using 3 D MRI and network analysis were evaluated. Participants consist of 106 adults with relapsing-remitting multiple sclerosis. Scores of Montreal cognitive assessment test, symbol digit modality Test, nine-hole peg test, berg balance scale test, timed up and go test, timed 25-foot walk test were worse in faller group than non faller group (p < 0.05 for all tests). There was no significant difference in terms of cerebellar lobule volumes between groups. But using artificial intelligence (AI) based network analysis, we brought a new perspective to interpreting the relationship between the cerebellum, cognition, gait, and balance. Overall, data from the study suggest a possible relationship between cerebellar volume changes and cognitive dysfunction through connectivity analysis in patients with multiple sclerosis. Further studies are needed to examine this issue by using connectivity analysis. [ABSTRACT FROM AUTHOR]

The St Jude Total Therapy Study XV was the first clinical trial to prospectively use minimal residual disease levels during and after remission induction therapy to guide risk-directed treatment. We used the Total Therapy XV protocol with minimal modification in treating 115 newly diagnosed pediatric acute lymphoblastic leukemia patients from low- and middle-income groups from January 2011 to December 2017. The mean age at diagnosis was 5.97 ± 3.96 years. The median follow-up period was 88 months. Three (2.6%) patients had bone marrow relapse, and one (0.87%) had an isolated central nervous system relapse. Nineteen of the patients (16.52%) died due to infection-related complications, three (2.61%) died due to progressive disease, and one (0.87%) died due to hematopoietic stem cell transplant complications. Five-year overall survival was 80%, and event-free survival was 78.3%. Our results showed that the Total XV treatment protocol could be used successfully in patients with ALL from low- and middle-income populations. However, infection-related deaths remain a significant problem. [ABSTRACT FROM AUTHOR]

The ligands 2,4-bis(2-hydroxyphenyliminomethyl)-6-methyl-1,3,5-triazine (AGSAL), 2,4-bis(2-carboxyphneyliminomethyl)-6-methyl-1,3,5-triazine (AG2FBA), and 2,4-bis(4-carboxyphneyliminomethyl)-6-methyl-1,3,5-triazine (AG4FBA) were prepared with a Schiff base condensation between acetoguanamine and the corresponding salicylaldehyde, 2-formylbenzoic acid, and 4-formylbenzoic acid. High-spin (S = 5/2) complex [FeIII(AGSAL)Cl] was obtained by complexation of AGSAL with FeCl3. Then, binuclear complexes [{FeIII(AGSAL)}2(AG2FBA)] and [{FeIII(AGSAL)}2(AG4FBA)] were prepared by combination of [FeIII(AGSAL)Cl] and "(AG2FBA), (AG4FBA)," respectively. Then, trinuclear complexes [{FeIII(AGSAL)}2(FeIIIAG2FBA)] and [{FeIII(AGSAL)}2(FeIIIAG4FBA)] of the ligands were prepared by reaction of the binuclear complexes and FeCl3 salt. A weak antiferromagnetic exchange was found for all complexes. Finally, the structures of ligands and complexes were identified by using elemental analysis, magnetic susceptibility, 1H NMR, 13C NMR and FT-IR spectral data. [ABSTRACT FROM AUTHOR]

Royal Jelly (RJ) is one of the many important honey bee products that is also a functional food item in the regulation of diets and in the cosmetic industry. Many factors affect the composition of RJ. There is not enough information about the composition of early harvest (earlier than 72 h) RJ. In addition, no information has been found regarding the number of grafted larvae in reviewed studies. Thus, in this article, the effect of harvest time and the number of queen cell cups on the RJ composition such as 10-HDA, total and soluble proteins, furosine, superoxide dismutase activity (SOD), phenolic compounds have been determined. Results showed that 10-HDA values ​​decreased (3.2 ± 0.195%, 2.84 ± 0.146% and 2.16 ± 0.117%) as the numbers of larvae were increased (30, 60 and 120). Similarly, as the harvest time extended (24, 48 and 72 hours) the values ​​of 10-HDA decreased (3.25 ± 0.206%, 2.71 ± 0.137% and 2.24 ± 0.13%). Total protein ratios in RJ according to harvest times (24, 48 and 72 hours) were 19.6 ± 0.71%, 16.8 ± 0.57% and 16.8 ± 0.27%, respectively. Furosine values (ranging from 17.6-20.6 mg/100 g protein) increased as RJ harvest time increased. Superoxide dismutase activity values (ranging from 1.07 ± 0.06 to 1.47 ± 0.07 U/g) decreased as the number of grafted larvae increased and the harvest time increased. Phenolic compounds (151.7 ± 2.36 µg/g) were different from 48 (83.5 ± 3.89) and 72 hours (96.81 ± 5.97) royal jelly in the harvested RJ 24 hours after larvae grafting (P < 0.05). As a result, the RJ harvest time and the number of grafted larvae influenced the RJ composition. [ABSTRACT FROM AUTHOR]

With the advent of digital media and social media platforms, the speed of innovation and technology adoption in campaigns have increased tremendously. At the same time, the campaign environment and its rules are in constant flow, as platform logics, party operations, and voter alignments both reflect and create instability in many political systems. Additionally, disinformation, foreign interference in campaigns, hyper-partisan media ecologies, and hyperactive users have all created changes in opinion climates. In light of these developments, and building on the theoretical concept of increasingly disrupted and dissonant public spheres (developed by Barbara Pfetsch and Lance Bennett), this special issue seeks to expand research on campaigning beyond assumptions of well-functioning political systems, to better understand the erosion of institutional legitimacy and trust, and their effects on communication processes. The special issue is organized within two conceptual approaches. The first cluster of manuscripts observes how political candidates, organizations, and parties optimize their behaviour within the dissonant political environment. The second part examines responses, perceptions, and consequences of the disrupted environment on the public. Finally, four integrated forum essays look into how dissonant public spheres may disturb democratic processes, discuss the role of data-driven campaigning, and address how limited access to platform data affects our understanding of dissonant public spheres. [ABSTRACT FROM AUTHOR]

Relating to theories of dissonant public spheres and affective publics, we study negativity, dramatization, and populist content in political party Facebook posts across 12 countries during the 2014 and 2019 European Parliament Election campaigns. A quantitative content analysis of 14,293 posts from 111 (2014) and 116 (2019) political parties shows that negative emotion, negative campaigning, dramatization, and populist content has increased over this time. We show that political parties sought to evoke more negative emotions and generate more dramatization, engaged more in negative campaigning, and included more populist content in their Facebook posts in the 2019 EP election than in 2014. Further, we show that posts evoking negative emotions and dramatization and involving negative campaigning yield higher user engagement than other posts, while populist content also led to more user reactions in 2014, but not in 2019. Negative, exaggerated, and sensationalized messaging therefore makes sense from a strategic perspective, because the increased frequencies of likes, shares, and comments make parties' messages travel farther and deeper in social networks, thereby reaching a wider audience. It seems that the rise in affective and dissonant communication has not emerged unintentionally, but is also a result of strategic campaigning. [ABSTRACT FROM AUTHOR]

Political participation opportunities have been expanding for years, most recently through digital tools. Social media platforms have become well integrated into civic and political participation. Using a cross-national sample from the United States, United Kingdom and France, this article examines whether acts of participation associated with social media should be classified using a traditional, five-factor solution to the structure of participatory acts. The distinction between online and offline participation is set aside, focusing instead on acts supported and enabled by social media, and in particular on differences between the use of Twitter and Facebook. The analysis shows that acts enabled by social media do not load with traditional factors in the structure of participation. Political acts employing Twitter and Facebook are distinct in the factor structure of participation. [ABSTRACT FROM AUTHOR]

Remote self-assessment of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an add-on to ALSFRS-R assessments during multidisciplinary clinic visits. From August 2017 to December 2021, at 12 ALS centers in Germany, an observational study on remote assessment of the ALSFRS-R was performed. In addition to the assessment of ALSFRS-R during clinic visits, patients were offered a digital self-assessment of the ALSFRS-R – either on a computer or on a mobile application ("ALS-App"). An estimated multicenter cohort of 4,670 ALS patients received care at participating ALS centers. Of these patients, 971 remotely submitted the ALSFRS-R, representing 21% of the multicenter cohort. Of those who opted for remote assessment, 53.7% (n = 521) completed a minimum of 4 ALSFRS-R per year with a mean number of 10.9 assessments per year. Different assessment frequencies were found for patients using a computer (7.9 per year, n = 857) and mobile app (14.6 per year, n = 234). Patients doing remote assessments were more likely to be male and less functionally impaired but many patients with severe disability managed to complete it themselves or with a caregiver (35% of remote ALSFRS-R cohort in King's Stage 4). In a dedicated ALS center setting remote digital self-assessment of ALSFRS-R can provide substantial data which is complementary and potentially an alternative to clinic assessments and could be used for research purposes and person-level patient management. Addressing barriers relating to patient uptake and adherence are key to its success. [ABSTRACT FROM AUTHOR]

The determination of antioxidant capacity, total phenolics, and ascorbic acid using accurate, efficient, low cost, and rapid methods has great analytical importance. The antioxidant capacity, total phenolics, and ascorbic acid content of apricots, arugula, banana, cranberries, spinach, and strawberries were investigated with an electrochemical approach and examined for compatibility with conventional methods. The antioxidant activity was determined by ABTS and DPPH assays. The total phenolic content was determined by the Folin Ciocalteu method and ascorbic acid was quantified by high-performance liquid chromatography (HPLC). In order to perform sensitive and simultaneous electrochemical measurements, the surface of a glassy carbon electrode (GCE) was modified by electropolymerization with p-toluene sulfonic acid (TSA). The TSA/GCE modified sensor was used for the first time for the determination of antioxidant capacity and total phenolic content. The surface of the modified sensor was characterized by cyclic voltammetry and scanning electron microscopy. The TSA/GCE was linearly correlated with the differential pulse voltammetry (DPV) for Trolox and gallic acid in 0.1 M NaNO3 and ascorbic acid in pH 7.4 phosphate buffer. Electrochemical methods offer a promising alternative for the determination of antioxidant capacity and total phenolic content due to their simplicity, rapid response, low cost, sensitivity, and reproducibility. [ABSTRACT FROM AUTHOR]

Phubbing (phone-snubbing) -a word to describe an interruption of a conversation due to using and/or glancing at a smartphone while communicating in person- has become an important problem. This unpleasant behavior can occur in different contexts like romantic relationships, business life, family relations, and educational environments. Previous researches generally focused on the first three situations; however, there is currently a lack of studies addressing phubbing behavior in an educational context. Although there have been insistent calls to examine the effects of phubbing behaviors in educational environments, to our knowledge, this study is the first which specifically focuses on supervisor-supervisee communication and the impact of phubbing behavior on this relationship. In this study, the term 'supervisor-phubbing' (SPhubbing) has been coined in the literature and described as "the supervisor's act of ignoring supervisees by using their smartphone or by being distracted by their smartphone during an academic meeting." Our research model, which draws upon Social Exchange Theory and Leader-Member Exchange Theory, examines whether SPhubbing results in any change to supervision outcomes or has an impact on trust between a student and their supervisor. Our results clearly show that SPhubbing has a negative impact on a student's trust in their supervisor which is important because trust positively impacts student satisfaction and perceived supervisor contribution to learning. In addition, student satisfaction is positively related to perceived supervisor contribution to learning. Students expect to be given the attention during a conversation; unless they are inclined to trust their supervisors less which undermines their supervision outcomes. [ABSTRACT FROM AUTHOR]