1. miR-15a and 16-1 Are Downregulated in CD4+ T Cells of Multiple Sclerosis Relapsing Patients.
- Author
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Lorenzi, Julio Cesar Cetrulo, Brum, Doralina G., Zanette, Dalila L., de Paula Alves Souza, Alessandra, Barbuzano, Fernanda Gonçalves, dos Santos, Antonio Carlos, Barreira, Amilton Antunes, and da Silva, Wilson Araujo
- Subjects
CD4 antigen ,T cells ,MULTIPLE sclerosis ,IMMUNE response ,APOPTOSIS ,GENE expression ,MICRORNA ,PATHOLOGY ,BCL-2 genes ,PATIENTS - Abstract
The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/16-1 in PBMC, CD4
+ , and CD8+ from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4+ T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4+ T cells from RR-MS patients, thereby affecting apoptosis processes. [ABSTRACT FROM AUTHOR]- Published
- 2012
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