1. Asterosaponins and glycosylated polyhydroxysteroids from the starfish Culcita novaeguineae and their cytotoxic activities.
- Author
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Ngoan, Bui Thi, Hanh, Tran Thi Hong, Vien, Le Thi, Diep, Chau Ngoc, Thao, Nguyen Phuong, Thao, Do Thi, Thanh, Nguyen Van, Cuong, Nguyen Xuan, Nam, Nguyen Hoai, Thung, Do Cong, Kiem, Phan Van, Kim, Young Ho, and Minh, Chau Van
- Abstract
Using combined chromatographic methods, two asterosaponins (compounds1and2), including a new compound novaeguinoside E (compound1), and six glycosylated polyhydroxysteroids (compounds3–8) were isolated from a methanol extract of the starfishCulcita novaeguineae. Their structures were determined on the basis of spectroscopic data (1H and13C NMR, HSQC, HMBC,1H–1H COSY, ROESY, and HRESI-MS) and by comparison with the literature values. The new compound1represents the third example of asterosaponins containing the 5α-cholesta-9(1l)-en-3β,6α,20,22-tetraol aglycone. Among isolated compounds,4–7exhibited moderate to weak cytotoxic activities against five human cancer cell lines such as Hep-G2 (hepatoma), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma). [ABSTRACT FROM AUTHOR]
- Published
- 2015
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