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This paper investigates a class of linear fractional programming (LFP) problem, which minimizes the sum of a finite number of linear fractional functions over a polyhedral region. Firstly, the equivalence problem (EP) of the LFP problem is given by a new two-stage transformation method. Secondly, considering the characteristics that the branch-and-bound algorithm can guarantee the global optimality of the solution to an optimization problem, and then based on the EP, we discuss the bounding operation, branching operation, pruning operation and rectangle-region reduction technique of this algorithm. After that, the convergence of the algorithm is proved and its computational complexity is deduced from the worst case. Finally, some experiments are reported to verify the effectiveness, feasibility and other performance of the proposed algorithm. [ABSTRACT FROM AUTHOR]