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This short research note serves as an update to the authors’ 2020 article examining the history of Martini-type rifles in Afghanistan between 1878 and 1925 (Arms & Armour, Vol. 17 No. 1). Ongoing research has permitted the revision of production estimates for Martini-type rifles produced by the Kabul Arsenal, and new estimates are presented herein. The earlier typology is also slightly modified for ease of use. [ABSTRACT FROM AUTHOR]

Tobacco quickly found favour in Japan after its introduction in the late sixteenth century, leading to the development of the kiseru—a distinctive Japanese tobacco pipe. Building upon a long-standing tradition of concealing weapons within a variety of mundane objects, tobacco pipes and smokers' accessories were soon modified to incorporate hidden spikes, blades, and even firearms. This short article, believed to be the first detailed assessment in the English language, explores the fascinating world of these covert self-defence tools. Through the examination of select artefacts, historical sources, and popular culture, this study provides a concise overview of these objects, shedding light on their design and purpose, and situating them within the broader Japanese arms and armour tradition. [ABSTRACT FROM AUTHOR]

To demonstrate changes in the demography and diagnosis of uveitis in a specialist clinic in the United Kingdom. Retrieval of data including all new referrals to Manchester Uveitis Clinic from 1991 to 2020. The incidence and proportions of diagnoses between 4 quartiles was compared. 5000 patients with uveitis were seen. Referral rates trebled over time. Highly significant increases in referrals were seen for multiple evanescent white dot syndrome-spectrum disorders, syphilis and tuberculosis; increases were also seen for herpetic retinitis, vitreoretinal lymphoma and sarcoidosis. Highly significant decreases were seen for Fuchs' uveitis, Behçet's uveitis and ocular toxoplasmosis. Subspecialisation and de-skilling has changed referral patterns to specialist clinics; changes cannot be entirely attributed to disease incidences, which also vary between countries. International data are non-comparable. There are clear changes in referral patterns and disease incidence in this population, influenced by evolving diagnosis. Local data should steer care planning. [ABSTRACT FROM AUTHOR]

In 1918, a Marshal's sword (Gensuitō) was introduced into the Japanese honours system, to be presented to specially recognised admirals and generals of the Imperial Japanese military who had been awarded the honorific title of Gensui. Later that year, a very fine example of such a sword was presented to King George V at Buckingham Palace, on behalf of Emperor Taishō. These swords were made to the highest standards by master swordsmiths, with no more than 24 produced before the abolishment of the rank of Gensui in 1945. Very little has been written about Gensuitō in Japanese, much less in English. The King George V Gensuitō, today held in the Royal Collection, is recognised for its aesthetic value, but has been the subject of only limited scholarship. Drawing on primary sources held in the Royal Collection, Royal Archives, and National Archives of Japan, as well as secondary sources published in limited-circulation journals that have not been digitised, the author presents herein an overview of this important Gensuitō—believed to be the sole example held in a collection outside of Japan. [ABSTRACT FROM AUTHOR]

Telehealth has long been highlighted as a way to solve issues of efficiency and effectiveness in healthcare and to improve patients' care and has become fundamental to address patients' needs during the COVID-19 pandemic; however previous studies have shown mixed results in the user acceptance of such technologies. Whilst many previous studies have focussed on clinical application of telehealth, we focus on the adoption of telehealth for virtual assessments visits aimed to evaluate the suitability of a property where a patient is discharged, and eventual adaptations needed. We present a study of stakeholders' attitudes towards such virtual assessment visits. The study has been carried out with healthcare professionals and patients and allowed us to identify user attitudes, barriers and facilitators for the success of virtual assessment visits from the point of view of healthcare professionals and patients. Finally, we discuss implications for designers of telehealth services and guidelines that can be derived from our study. [ABSTRACT FROM AUTHOR]

This article examines the 'Alphabet' series of prototype rifles which were developed at Winchester between 1912 and 1934, ultimately culminating in the Models 54 and 70. Drawing upon original research conducted in the Winchester archive at the Cody Firearms Museum and through physical examination of extant 'Alphabet' rifles, the authors have been able to more fully map the lineage of the influential Model 70 and its predecessors and, in particular, clearly articulate the connection this American icon shares with the famous Mauser rifles of 1871—1898. [ABSTRACT FROM AUTHOR]

The Martini-Henry and other Martini-action rifles have played an important part in the cultural, martial, and commercial histories of Afghanistan. The Martini-Henry was the first purpose-designed breech-loading rifle adopted by the British military. Over the course of its lifespan, the Martini-Henry and its successors saw service in all corners of the British Empire, including Afghanistan and the neighbouring Northwest Frontier Province of British India. Afghan forces took quickly to the weapon. Copies of the Martini were produced in Afghanistan around the time of the Second Anglo-Afghan War (1878–1880), imported from Great Britain in subsequent years, and finally industrially produced at the Kabul Arsenal from 1894. These rifles helped Afghanistan's emirs to put down rebellion and maintain control, before being turned back on the British during the Third Anglo-Afghan War of 1919. In recent years industrially-produced examples originating from Great Britain, Belgium, Austria, and from the Kabul Arsenal in Afghanistan—as well as craft-produced examples from the Khyber Pakhtunkhwa region of Pakistan—have proven popular mementos. Many of these are now held in private collections in the United States, United Kingdom, Europe, and elsewhere, often brought home by International Security Assistance Force (ISAF) troops and others who deployed to Afghanistan from 2001 onwards. Despite the popularity of Martini-type rifles purchased in Afghanistan, little has been written about the local history of these weapons. In this article, the authors aim to: present an overview of the history of the Martini-type rifle in Afghanistan; clearly articulate the models of Martini-type rifles produced in Afghanistan; explain how to identify where, when, and by whom these were made; and support their conclusions with analysis based upon a sizeable original dataset. [ABSTRACT FROM AUTHOR]

Measuring sustainability is an integral part of decision-making processes in order to promote sustainable development. The present paper focuses on sustainability indicators as these are measured on local level and explores two main issues: firstly, the subjective measurement of indicators focusing especially on social dimensions of sustainability, secondly, the incorporation of local perceptions in sustainability assessments. These two issues are explored in the Asopos River basin in Greece, an area where significant environmental degradation has been observed in the past decades and is also under financial pressure due to the ongoing national recession. A large-scale research study was conducted measuring environmental, economic and social indicators while, at a second stage, a model was developed, estimating new indicators that incorporate local communities' perceptions on what they considered as important for their area. The results of the study reveal that the most important indicators for the sustainable development of the area, according to locals' perceptions, are environmental quality as well as quality of life. By contrast, trust in local and central institutions and also local enterprises were not considered as important by locals. These results illustrate the importance of combining global and national scale assessment with locally focused social measurements of sustainability in order to better understand what is important for local communities prior to embarking on public policy planning. [ABSTRACT FROM AUTHOR]

The elastic moduli and acoustic loss behaviour of Ti-6Al-4V (wt.%) in the temperature range 5–298 K have been studied using Resonant Ultrasound Spectroscopy. A peak in the acoustic dissipation was observed at 160 K within the frequency range 250–1000 kHz. Analysis of the data acquired in this study, coupled with complementary data from the literature, showed that this was consistent with a Snoek-like relaxation process with an associated activation energy of 233 kJ mol. However, the loss peak was broader than would be expected for a Snoek-like relaxation, and the underlying process was shown to have a spread of relaxation times. It is suggested that this effect arises as a result of variations in the strain experienced by thephase due to different local microstructural constraint by the bounding secondaryphase. [ABSTRACT FROM AUTHOR]

Purpose: To demonstrate the manifestations and complications of uveitis, and their medical and surgical management, in a very large group of patients attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the Northwest of England, UK. Methods: Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013. Results: A total of 3000 new patients with uveitis were seen during a 22-year period, of which 25.2% had a single acute episode, 13.6% had acute recurrent uveitis, 20.2% had chronic fluctuating uveitis, and 41.0% had chronic unremitting uveitis. The commonest complications were cataract (35% of patients), macular edema (20.5%), and glaucoma (19.5%). Oral steroids were required in 36% of patients, oral immunosuppression in 16%, and biologic treatment in 2%. Major intraocular surgery was required in 28%. Conclusions: Oral steroid usage is not an independent risk factor for cataract formation in patients with uveitis. Oral immunosuppression usage has increased 4-fold during this study period. [ABSTRACT FROM AUTHOR]

B chromosomes (Bs) can be described as “selfish chromosomes”, a term that has been used for the repetitive DNA which comprises the bulk of the genome in large genome species, except that Bs have a life of their own as independent chromosomes. They can accumulate in number by various processes of mitotic or meiotic drive, especially in the gametophyte phase of the life cycle of flowering plants. This parasitic property of drive ensures their survival and spread in natural populations, even against a gradient of harmful effects on the host plant phenotype. B chromosomes are inhabitants of the nucleus and they are subject to control by “genes” in the A chromosome (As) complement. This interaction with the As, together with the balance between drive and harmful effects makes a dynamic system in the life of a Bs. In this review, we concentrate mainly on recent developments in the Bs of rye and maize, two of the species currently receiving most attention. We focus on their population dynamics and on the molecular basis of their structural organisation and mechanisms of drive, as well as on their mode of origin and potential applications in plant biotechnology. [ABSTRACT FROM PUBLISHER]

Background: The Reserves Mental Health Programme (RMHP) provides a clinical service for members of the United Kingdom's Reserve Forces deployed to combat operations since 2003. Aim: To assess whether mental health and occupational functioning changed after treatment. Methods: We examined a treatment group with operationally attributable mental health problems and a non-intervention group with non-operationally attributable problems. A self-report, repeat measures study design examined post traumatic stress disorder (PTSD), common mental disorders, alcohol use and occupational functioning at follow up delivered by either telephone or post. Results: One hundred three reservists were offered an initial assessment. Adjusted response rates were 66.7%% ( n == 16) for the no treatment group and 62.7%% ( n == 37) for the treatment group. The treatment group were more likely to be cases at baseline on all mental health outcome measures other than PTSD, but at follow up, they were no more likely to be so. A one-way ANCOVA was conducted to evaluate treatment outcome. This was not significant for all measures except for PTSD. On completion of treatment, three quarters of serving personnel returned to full occupational fitness. Conclusion: The RMHP appears to offer a clinically and occupationally effective intervention to recently de-mobilised reservists with operationally attributable mental health problems. [ABSTRACT FROM AUTHOR]

Mantle-cell lymphoma (MCL) is a B-cell malignancy with distinct molecular genetics and pathological features. Peripheral blood involvement has been reported with variable frequency, but information on the natural history of cases presenting with leukemia is lacking. This study aimed to determine the clinical and prognostic features of such cases. We studied clinical features, tumor characteristics, prognostic factors and outcome in 58 patients with leukemic presentation of MCL. Diagnosis was based on morphology, immunophenotype, presence of t(11;14), histology and cyclin D1 expression. The median age was 62 years and male : female 2.4 : 1. Presenting features included splenomegaly (74%), lymphadenopathy (45%), hepatomegaly (17%) and, in a minority, gastro-intestinal involvement or involvement of Waldeyer's ring; 10% had lymphocytosis alone. Six patients developed central nervous system disease. Median lymphocyte count was 58 × 10 9 /l, 55% had anemia and 17% had thrombocytopenia. Morphology of peripheral blood showed small-cell MCL in 15% of cases, typical MCL in 46% and blastoid MCL in 39%. Immunological markers showed a typical phenotype (CD5 + CD23 - ) in 68%, and atypical phenotypes, CD5 - CD23 - in 17% or CD5 + CD23 + in 15%. CLL scores were 0, 1 or 2 in 96%. Median overall survival was 36 months. Good response to first-line treatment ( P  = 0.0008) and splenomegaly ( P  = 0.03) were favorable prognostic factors, while other features including morphology and CD38 expression had no impact on survival or treatment response. This analysis demonstrates that except for splenomegaly, survival of MCL patients presenting with leukemia is not significantly influenced by clinical or tumor characteristics. Splenectomy is a useful treatment option in this group of patients. [ABSTRACT FROM AUTHOR]

Cerebrospinal fluid (CSF) rhinorrhoea has been managed by both neurosurgeons and otorhinolaryngologists, with neurosurgeons often choosing an intracranial approach and otorhinolaryngologists an extracranial approach. Recently, transnasal endoscopic techniques have been introduced that significantly reduce the morbidity of surgical repair when compared with previous techniques. The sense of smell was preserved in all patients who underwent an endoscopic repair of their CSF leak where it was present preoperatively. The results of transnasal endoscopic repair now make it the treatment of choice for most anterior cranial and sphenoid CSF leaks, with the exception of defects in posterior wall of the frontal sinus or defects larger than 5 cm. It is vital that a diagnosis of a CSF leak is confirmed by immunofixation of beta 2 transferrin as unilateral rhinorrhoea can masquerade as a CSF leak. We illustrate our experience with 78 patients who were referred with a diagnosis of CSF rhinorrhoea. [ABSTRACT FROM AUTHOR]

In surface plasmon resonance (SPR) fibre-optic sensors, the optical power transmittance is important in determining behaviour. In this paper numerical calculations are used to estimate the optical power transmittance of SPR fibre-optic sensors. These analytical estimations can be applied in SPR fibre-optic sensors both with a transducing layer and without a transducing layer. The results of these numerical calculations agree well with previously published experimental results. This work will aid in the design of SPR fibre-optic sensors in terms of geometrical structure, materials and dynamic range as well as allowing the prediction of performance and of limitations of the design. [ABSTRACT FROM AUTHOR]

Summarizes a number of industrial applications of thermography. Rationale for using thermography; Advantages of thermography; Discussion of its various applications in the industrial setting.

In an optical fibre of circular cross section, leaky skew rays transmit power in a different way from trapped and meridional rays. In this paper, a theoretical analysis of the evanescent wave absorption coefficient for leaky skew rays in multimode optical fibre evanescent wave absorption sensors is presented. Further, a comprehensive expression for the effective evanescent wave absorption coefficient is obtained. Some numerical results are given to illustrate this theoretical analysis. This work could be applied to optimize the design of fibre-optic evanescent wave absorption sensors. [ABSTRACT FROM AUTHOR]

Excavations just inside the main west gate of the town, a plantation of probably the later twelfth century, confirm that parts of the town that were intensively occupied in the thirteenth and fourteenth centuries were abandoned as the settlement shrank and diminished in status from the later fifteenth century onwards. The earliest buildings, founded on earth-fast posts appear to have been replaced by ones of sill-beam construction during possibly the later thirteenth and fourteenth centuries. One structure was converted into an ironworking smithy in the fourteenth or fifteenth century, to which a corn-drying kiln was attached. Charred remains of cultivated plants are dominated by oats, most of which probably represents crop processing activity. [ABSTRACT FROM AUTHOR]

Purpose: To describe practical approaches to the management of subluxed or dislocated intraocular lenses (IOL) in patients with uveitis.Patients and methods: Retrospective case series from a specialist uveitis clinicResults: Fifteen IOLs in 13 patients were subluxed inferiorly (12) or dislocated into anterior chamber (2) or vitreous (1) at a mean delay of 12 years after cataract surgery. Six eyes required vitrectomy and seven IOL explantation. A dislocated IOL was repositioned by scleral fixation in one, and a new IOL was implanted in three (two scleral-sutured, one iris-claw). Eight were observed without surgery and 7 were left functionally aphakic (4 corrected with contact lens). The mean final best-corrected visual acuity was 0.6 LogMAR.Conclusions: There are several management choices for IOL dislocation which should take into account the degree of uveitis, patient age and expectations. We present a pragmatic approach: surgery can often be avoided in this high-risk group. [ABSTRACT FROM AUTHOR]

Purpose: Cytomegalovirus retinitis (CMVR) is a serious and potentially sight-threatening infection in immunocompromised individuals. Strategies for the management of drug-resistant CMVR are described. Methods: A case of severe bilateral CMVR in a single lung transplant patient, with UL97 mutation conferring ganciclovir-resistance, is presented. Treatment with standard antiviral agent and adjuvant leflunomide, immunosuppression modifications (calcineurin inhibitors and corticosteroid), intravitreal antiviral therapy and novel use of CMV-immunoglobulin is described. A literature review to support drug-resistant CMVR management is presented. Results: Severe and progressive CMV retinitis was refractory to intravitreal foscarnet and systemic leflunomide. Drug-toxicity restricted systemic antiviral therapy options. The use of combined leflunomide and CMV-immunoglobulins, in the absence of viremia, has not been previously reported. Loss of ganciclovir-resistance was eventually observed permitting successful treatment with systemic and intravitreal ganciclovir. Conclusions: Drug-resistant CMVR is a complex clinical challenge. Multiple systemic and local treatment strategies may be necessary but toxicity, resistance, and co-morbidities may severely restrict available options. [ABSTRACT FROM AUTHOR]

Purpose: To describe inferior peripheral retinal elevations associated with intermediate uveitis. Methods: Retrospective review. Results: Eleven eyes of 7 patients developed inferior retinal elevation secondary to intermediate uveitis. Six eyes (54.6%) were believed to have tractional retinoschisis, 2 (18.2%) had tractional retinal detachment, and the remaining 3 (27.3%) had flat retinal elevation of indeterminate type. In 10 eyes there was no evidence of progression during a mean 4-year follow-up. One eye developed extended tractional elevation with macular pucker and failed to respond to surgery. At the most recent visit, visual acuity ranged from 6/5 to NPL with a median of 6/12. Conclusion: Intermediate uveitis may cause inferior peripheral retinal elevation. The authors propose that preretinal and pars plana gliosis resulting from chronic pars planitis exerts traction on peripheral retina, causing elevation, but infer that such elevation removes traction and is self-limiting. Surgery should be reserved only for macula threatening lesions. [ABSTRACT FROM AUTHOR]

Reductions in information processing speed have frequently been reported following moderate and severe traumatic brain injuries (TBIs), consistent with the effects of diffuse white matter damage. Although the corpus callosum (CC) is a common site for diffuse damage following TBI, the effects of this damage on information processing speed have not been adequately examined. This study assessed a TBI group and a matched control group on tests of attention, memory, fluency, and set shifting ability, together with reaction time (RT) tasks requiring the inter- and intrahemispheric processing of visual and tactile information. The RT tasks were designed to target the cognitive functions that are likely to be affected by diffuse white matter damage, including damage to the CC. The TBI group demonstrated deficits in verbal and visual fluency and verbal memory. They were also slower on the visual and tactile RT tasks, were more affected by task complexity, and slower on RT tasks requiring the interhemispheric transfer of information. In fact, one of the interhemispheric tactile RT tasks proved to be the most discriminating of all the cognitive and RT measures. MRIs completed on a subset of TBI participants indicated that the mean CC measurements were 5% to 19% smaller than a normative control group, with the most atrophied areas being the isthmus and anterior midbody. Although white matter atrophy was moderately related to visual and tactile RT performance, and total hippocampal volume related to memory performance, CC area was not related to many of the tasks that were designed to tap interhemispheric processing. None of the standard cognitive tests correlated with outcome in the TBI group, but 1 of the tactile RT measures was significantly related to 2 measures of outcome. [ABSTRACT FROM AUTHOR]

Purpose: To test the possible involvement of the XRCC2 gene in the control of intra- versus interchromatid rearrangements leading to chromatid breaks in G2 cells by studying the colour-switch ratio (CSR) in harlequin-stained Chinese hamster irs1 cells. Materials and methods: The V79-4 mutant cell lines irs1 (XRCC2 mutation) and irs2 (XRCC8 mutation), two WT V79 lines and GT621-1 (irs1 transfected with the XRCC2 gene) were labelled with BrdU through two cell cycles, irradiated and sampled 1.5h after exposure. Metaphase spreads were analysed for chromatid break frequency and frequencies of colour-switch (colour-switch between chromatids at the break point) and non-colour-switch breaks, from which the CSR was calculated. Results: Chromatid breaks were induced linearly with dose in all lines, and frequencies were elevated in irs1 and irs2 mutant cell lines when compared with WT lines. An XRCC2 transfected line (GT621-1) showed full radiosensitivity complementation with respect to frequencies of chromatid breaks. The CSR was significantly higher in irs1 (13.9%) than in the parental V79-4 (7.5%) or irs2 (4.9%) cells. GT621-1 cells showed partial, but significant complementation with respect to CSR (9.2%). Conclusions: It is concluded that the significantly higher CSR for the irs1 mutant than for the wild-type parental V79-4 line indicates the involvement of the XRCC2 gene product in the control of the rearrangement process leading to chromatid breaks. [ABSTRACT FROM AUTHOR]

We present a technique for rectifying distorted imagery collected by an upward-looking, submerged camera for the purpose of reconstructing the above-surface scene. Radial surface slope is deduced near extinction boundaries separating regions of transmission and internal reflection. The radial slope measurements are fit to an estimate of the distorting surface, which is recursively improved so as to minimize the quadratic measurement error. The surface is assumed to obey linear wave dynamics. After surface estimation, the above-surface scene is reconstructed by inverse ray tracing. Results of testing the wave estimation and inverse-ray tracing algorithms against simulated underwater data are presented. [ABSTRACT FROM AUTHOR]

(Pb 1-x Sr x )(Zr 0.976-y Ti y Nb 0.024 )O 3 solid solutions were investigated to understand the relationship between structural changes caused by Sr substitution on the A-site and dielectric, and piezoelectric properties. As Sr was substituted for Pb, the Zr:Ti ratio was modified so that compositions had an optimised piezoelectric coefficient (d 33 ). d 33 was at a maximum in the tetragonal phase close to, but not at, the morphotropic phase boundary (MPB). As Sr content increased, optimised d 33 also increased from 410pC/N (x = 0) to 640pC/N (x = 0.12), commensurate with a decrease in the paraelectric to ferroelectric phase transition temperature (T c ) from 350°C to 175°C. Low Sr concentrations (x = 0-0.08) contained 80nm ferrroelectric domains whereas high Sr concentrations (x = 0.12-0.16) contained fine-scale domains (20nm). In addition, [110] pseudocubic electron diffraction patterns revealed superlattice reflections at 1/2 {hkl} positions associated with rotations of the octahedra in anti-phase. [ABSTRACT FROM AUTHOR]

1. Urine was the major route of excretion of radioactivity (95 % dose in 0-24 h) following the oral, intravenous or intraperitoneal administration of [ 14C]-trimethylamine N-oxide dihydrate (1 mmol/kg body wt) to the adult male Wistar rat. A further 3-4% was voided in the urine during 24-72 h. Only fractional amounts were detected in the faeces, or were retained within tissues 3 days after administration. 2. Biliary secretion of radioactivity was insignificant (0.18 % in 0-4 h) but larger amounts were secreted directly into the lumen of the gastrointestina l tract, especially the small intestine (2.6 % in 0-1 h). 3. The only radioactive compounds identified in the urine were trimethylamine Noxide and dimethylamine.Larger amounts of dimethylaminewere excreted following oral administration (10 %) as opposed to intravenous (2.5 %) or intraperitoneal (1.5 %) input. This production of dimethylamineoccurred over a 100-fold oral trimethylamineN-oxide dose range (0.3-30 mmol/kg body wt). Incubation of trimethylamine N-oxide with gut contents (especially colon and rectum) led to the formation of dimethylamine. [ABSTRACT FROM AUTHOR]