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A simple, efficient, ecofriendly, and cost-effective method has been developed for the synthesis of 16 spiropyrazolo pyrimidine derivatives (5a–5p) by a four-component, one-pot reaction of pyrimidine-2,4,6(1H,3H,5H)-trione, 3-oxo-3-phenylpropanenitrile, hydrazine, and isatins (4a–4f) by using nanocopper ferrite catalyst (20 mol%) in water with excellent yields (73–91%). The isatin with electron-withdrawing groups gave products in high yields (5hand5p). The present methodology offers an environmentally benign, cost-effective, high-yielding method with recyclable catalyst. The drug likeness or “drugability” of all the synthesized compounds were tested through rule of five (RO5) parameters. Compounds5f, 5h, 5n, and5phave shown one RO5 violation each. The compounds were screened for their antibacterial activity against human pathogenic bacteria wherein two of the synthesized compounds were found to possess significant antibacterial activity. Compounds showing RO5 violations had negligible antibacterial activity. [ABSTRACT FROM PUBLISHER]

A hindcast simulation of storm surge and inundation from tropical cyclone Phalin, which made landfall at Odisha, India, on 12 October 2013, was carried out using ADCIRC model. Model-simulated inundation extent matched well with field surveys at Ganjam, Odisha, within a few days of landfall. Further, the model reproduced the temporal evolution of the surge residual with respect to observations from a tide gauge at Paradip (correlation 0.8, RMSE 0.26 m). However, the model marginally underestimated the magnitude with respect to observations, which can be attributed to the lack of wave setup in the model and uncertainty in wind and pressure information. The experiment also involved the use of two idealized scenarios, that is, variation of landfall timings with the ebbing and high tide phase. These scenarios were required for better understanding the sensitivity of inundation to the phase of tide in the model. Simulation with landfall at flooding (ebbing) tide showed greater (lower) inundation than the real scenario. Results from idealized scenarios confirmed the significance of the accuracy needed in forecasting landfall time. Our results clearly indicate that the overall performance of the model is good and therefore is of potential use as a tool to forewarn disaster management authorities. [ABSTRACT FROM AUTHOR]

A new sphingolipid, (2 S ,3 R ,4 E )-1,3-dihydroxy-2-[(nonadecanoyl) amino]-octadec-4-ene ( 1 ) along with ubiquitous batyl alcohol is isolated from the gorgonian, Junceella juncea Pallas (Gorgonaceae) of the Indian Ocean. The structure of 1 is determined on the basis of 1 H- and 13 C-NMR, COSY, FABMS, and GC-EIMS experiments. [ABSTRACT FROM AUTHOR]