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The emergence of AI has revolutionized video production, enabling innovative approaches in artistic creation. With self-media's rise and demand for user-generated content, AI drives personalized, efficient video production. However, research lacks comprehensive reviews of AI's impact on film and TV. This study fills the gap by analyzing AI's influence using a five-sub-field framework. Through literature integration, we assess AI video production's potential, proposing a new process paradigm. This research sheds light on AI's transformative role, guiding efficient, personalized film and TV production, and inspiring deep learning-based advancements. This paper acts as a roadmap for maximizing AI's potential in enhancing production quality and efficiency. [ABSTRACT FROM AUTHOR]

Recently, the data generated are exploding in the information age. In the post-COVID-19 era, some real estate contracts have been signed online, and online advertisement recommendation has become a new way to reduce the searching cost. Therefore, the model in which real estate online recommendations can be made suitable without user preferences has become a tricky problem. This study uses sentiment and economic data to predict real estate sales and then made an advertisement recommendation from the forecast results. The 2SA-RERec (Two Sentiment Analysis of Real Estate Recommendation) model is proposed, which shows the highest accuracy among the others. [ABSTRACT FROM AUTHOR]

One of the most important factors that limit the potency of CD8+cytotoxic T lymphocyte (CTL) responses is the tumor microenvironment (TME). Here, we provide evidence that miR-26a is a negative regulator of CTL function in the TME. Specifically, we identified miR-26a as a crucial suppressor gene in CTLs from the TME, as we found that, miR-26a expression was elevated in CTLs to respond to TME secretome stimulation. CTLs from miR-26a-transgenic mice showed impaired IFNγ and granzyme B production in response to their cognate antigen. Conversely, we found that miR-26a inhibition in CTLs could effectively increase the cytotoxicity and suppress tumor growth. Mechanically, we identified EZH2 as a direct target of miR-26a. miR-26a and EZH2 expression were found to be inversely correlated in CTLs, and the inhibition of EZH2 in CTLs impairs CTL function. These functional correlations were validated in a cohort of non-small cell lung cancer patients, indicating that the miR-26a-EZH2 axis is clinically relevant. Our findings suggested that miR-26a silencing as a novel strategy to improve the efficacy of CTL-based cancer immunotherapy. [ABSTRACT FROM AUTHOR]

A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire ‒ including antigen specificity, clonality, as well as its prognostic significance ‒ remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study the landscape and compartmentalization of these patients’ TCR β repertoire by deep sequencing analyses. Our results illustrated antigen-driven expansion within the tumor compartment and the contracted size of shared clonotypes in mucosa and peripheral blood. Most importantly, the diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse. [ABSTRACT FROM PUBLISHER]

In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT. [ABSTRACT FROM PUBLISHER]