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A convenient approach to modify bioactive substrates such as daunorubicin, cytisine, and camphecene with a pentafluorosulfanylvinyl moiety have been suggested. F5S-CH = CH derivatives of daunorubicin were obtained by acylation with reactive 4-nitrophenyl-4-(pentafluoro-λ6-sulfanyl)alkenyl carbonates, while the corresponding conjugates of anthracycline antibiotic daunorubicin, alkaloid cytisine and camphecene were synthesized using a click chemistry procedure. [ABSTRACT FROM AUTHOR]

Novel phosphorus-containing ligands have been synthesized by the condensation of 2-(thio)phosphorylated anilines with 2,6-dichloro- and 4-chloropyridine-2-carbonyl chlorides in the presence of Et3N and unsubstituted pyridine-2-carboxylic acid using P(OPh)3as a coupling agent. The compounds derived readily form complexes with a range of transition metals (M=Re(I), Pd(II), and Cu(II)), serving as bi- or tridentate monoanionic ligands. The composition and structure of the resulting metallocycles depend both on the presence/amount of the Cl atoms in the pyridine ring and on the nature of the donor atom X in the P=X moiety. The novel compounds were characterized by multinuclear NMR and IR spectroscopy as well as X-ray crystallography. [ABSTRACT FROM PUBLISHER]

New 1,2-alkadienylphosphonates and diphenyl(1,2-alkadien-1-yl)phosphine oxides were synthesized by a convenient and efficient method. These compounds are useful as intermediates in the preparation of 2-(diethylphosphoryl)-3-(3-phenyl-4,5-dihydroisoxazol-5-yl)-2H-azirines, 2-(diethylphosphoryl)-3-vinyl-2H-azirines and diphenyl(3-isopropenyl-2H-azirin-2-yl)phosphine oxides. [ABSTRACT FROM PUBLISHER]