1. Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia.
- Author
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Xiao, Jing, Niu, Jianying, Ye, Xianwu, Yu, Qianqian, and Gu, Yong
- Subjects
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PREECLAMPSIA diagnosis , *KIDNEY injuries , *SERUM , *ENZYME-linked immunosorbent assay , *HYPERTENSION in pregnancy , *BIOMARKERS , *CYSTATINS , *GESTATIONAL age - Abstract
Objective: To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia. Methods: The level of serum and urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), retinol-binding protein (RBP) and interleukin-18 (IL-18) were measured by enzyme-linked immunosorbent assay. Results: The level of serum cystatin C, urine RBP, urine NGAL and urine KIM-1 in preeclampsia group were higher than that in the normal pregnancy group. When four biomarkers are combined, the sensitivity and specificity are 100%/98.20%. Conclusion: Urine KIM-1 is the most potential biomarker for renal injury in preeclampsia. The more biomarkers combined, the more sensitivity and specificity were increased. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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