15 results on '"Niu, Xiao"'
Search Results
2. Evidence and possible mechanism of Scutellaria baicalensis and its bioactive compounds for hepatocellular carcinoma treatment.
- Author
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Ma, Ming-Yue, Niu, Xiao-Ji, Wang, Qian, Wang, Shou-Mei, Li, Xin, and Zhang, Shu-Hui
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CHINESE skullcap ,HEPATOCELLULAR carcinoma ,BIOACTIVE compounds ,CHINESE medicine ,CHEMOEMBOLIZATION - Abstract
Traditional Chinese medicines have been reported to have outstanding effects in the treating of hepatocellular carcinoma. Scutellaria baicalensis (S. baicalensis) has demonstrated anti-tumor, anti-angiogenic, and anti-inflammatory properties. Baicalein, wogonin, and baicalin are the main pharmacologically bioactive compounds of S. baicalensis. Eight electronic databases were searched to select articles published from their inception to 30 May 2022. For selected articles, clinical and preclinical data was obtained on the use of S. baicalensis and its bioactive compounds in hepatocellular carcinoma therapy. Statistical analyses were performed using RevMan version 5.3 and Stata software. Quality assessment of the studies was performed using Cochrane and Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE)'s risk of bias tools. Seven clinical and 17 preclinical in vivo studies along with 31 in vitro studies were included in this research. Meta-analysis showed that a Chinese herbal medicine preparation, with S. baicalensis as the sovereign herb, combined with Transcatheter arterial chemoembolization (TACE) or primary treatment, could lead to a significantly improved tumor objective response rate (Risk ratio (RR) = 1.57, 95% confidence interval (CI): [1.30, 1.90], p < 0.00001). Scutellaria baicalensis-based extracts (standard mean difference (SMD) = –0.86, 95%CI: [–1.20, −0.53], p < 0.00001), baicalein (SMD = –4.80, 95%CI: [–6.66, − 2.95], p < 0.00001), baicalin (SMD = –2.28, 95%CI [–3.26, −1.30], p < 0.00001) and wogonin (SMD = –1.41, 95%CI [–2.26, −0.57], p < 0.00001) slowed tumor growth in vivo. These outcomes might be linked to the mechanism by which S. baicalensis promotes apoptosis, induces autophagy, and blocks the expression of vascular endothelial growth factor (p < 0.05). Based on experimental and clinical evidence, we believe that S. baicalensis and its bioactive compounds have therapeutic potential and plausible mechanisms of action against hepatocellular carcinoma, in terms of efficacy and safety. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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3. Orthogonal dictionary learning based on l4-Norm maximisation for seismic data interpolation.
- Author
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Yue, Jingnan, Fu, Lihua, Niu, Xiao, and Fang, Wenqian
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INTERPOLATION ,CONVEX sets ,CONVEX functions ,COMPUTATIONAL complexity ,ORTHOGONAL matching pursuit - Abstract
Due to geological conditions, acquisition environment, and economic restrictions, acquired seismic data are often incomplete and irregularly distributed, and this affects subsequent migration imaging and inversion. Sparse constraint-based methods are widely used for seismic data interpolation, including fixed-base transform and dictionary learning. Fixed-base transform methods are fast and simple to implement, but the basis function needs to be pre-selected. The dictionary learning method is more adaptive, and provides a means of learning the sparse representation from corrupted data. K-singular value decomposition (K-SVD) is a classical dictionary learning method that combines sparse coding and dictionary updating iteratively. However, the dictionary atoms are updated column-by-column, leading to high computational complexity due to long SVD calculation times. In this study, we evaluated the dictionary learning method via l
4 -norm maximisation using an orthogonal dictionary, which is different from the traditional l0 -norm or l1 -norm minimisation, and interpolated the missing traces in the projection onto convex sets (POCS) framework. The optimal objection function is convex, but can be solved using a simple and efficient Matching, Stretching and Projection (MSP) algorithm, which greatly reduces the dictionary learning time. Numerical experiments using synthetic and field data demonstrate the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]- Published
- 2023
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4. Two new dinor-eudesmane sesquiterpenoids from the roots of Chloranthus multistachys.
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Xie, Xiao-Yu, Yang, Yi-Xuan, Gao, Xin, Liu, Qian, Liu, Zi-Han, Niu, Xiao-Feng, and Liu, Xia
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MEDICINAL plants ,TERPENES ,VEGETABLE oils ,PLANT roots ,PLANT extracts ,MOLECULAR structure ,CHROMATOGRAPHIC analysis ,CELL lines ,SPECTRUM analysis - Abstract
Two new dinor-eudesmane sesquiterpenoids, named multistalin A (1), and multistalin B (2), together with three sesquiterpene glycosides (3–5), and a norlabdane-type diterpene (6) were isolated from the root extract of Chloranthus multistachys Pei. Their structures were elucidated on the basis of spectroscopic analysis including 1D, 2D NMR techniques and HR-ESI-MS. In addition, the cytotoxicity activities of the isolated compounds against selected cancer cells (Hela and A-549) were evaluated by MTT assay. [ABSTRACT FROM AUTHOR]
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- 2022
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5. The cytoprotective role of omentin against oxidative stress-induced PC12 apoptosis.
- Author
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Shi, Wen-Zhen, Li, Wu, Cheng, Ye, Zhang, Meng, Niu, Xiao-Chen, Gao, Qi-Wei, Lu, Ying, Tian, Tian, Du, Shan, Mi, Yan, Chang, Ming-Ze, and Tian, Ye
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APOPTOSIS ,HYDROGEN peroxide ,OXIDATIVE stress ,MICRORNA ,WESTERN immunoblotting ,CYTOPROTECTION - Abstract
Oxidative stress has been proven to play a critical role in the pathogenesis of neuronal injury. As a novel adipocytokine, omentin is produced by visceral adipose with insulin sensitizing effects and has been revealed to possess anti-inflammatory effects. However, the possible effect of omentin on oxidative stress remains unknown. The present study aimed to detect the potential protective effect of omentin against hydrogen peroxide (H
2 O2 )-induced cytotoxicity of PC12 cells. The results showed that no cytotoxic effect was shown in PC12 cells co-cultured with omentin alone at a concentration of 50–1000 ng/mL. The CCK8 and TUNEL assays suggested that omentin could remarkably attenuate apoptosis induced by 100 μM H2 O2 . The PCR and western blotting showed that the expression levels of Bax was significantly inhibited by omentin via the upregulation of miR-128-3p at its 3′-UTR. Taken together, these results indicated that omentin protects PC12 cells against H2 O2 -induced apoptosis, and further studies need to be conducted before utilization in the clinic for the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]- Published
- 2021
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6. Scientists, institutions and the social nature of international collaboration: the accumulation of social capital in a system of social exchange.
- Author
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Turpin, Tim and Niu, Xiao
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SOCIAL systems , *SOCIAL dynamics , *SOCIAL processes , *SOCIAL institutions , *SOCIAL innovation , *SOCIAL capital , *COOPERATIVE research , *SOCIAL exchange - Abstract
International scientific collaboration is widely considered a driver of innovation. However, the social processes through which this can occur are complex. It is not only scientists that have a direct interest in international collaboration; but also the institutions or firms that employ them and the governments whose policies are designed to promote collaboration. This article seeks to reveal the social dynamics underpinning this process. Drawing on an empirical study of 79 scientists working in Australia and China we argue that the social process is essentially a system of exchange. Throughout this system, a range of scientific, innovation and social currencies are offered, received and reciprocated. Through the exchange process, scientific and technological capital is accumulated as different expectations are fulfilled and reconciled. Anthropological and sociological literature offers a theoretical framework for the analysis and the findings offer a sociological perspective of scientific collaboration across national innovation systems. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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7. Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.
- Author
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Gao, Si-Qian, Chang, Chen, Li, Jun-Jun, Li, Ying, Niu, Xiao-Qian, Zhang, Dan-Ping, Li, Long-Jian, and Gao, Jian-Qing
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WOUND healing ,DIABETES ,DIABETIC foot ,HYDROGELS ,DEFEROXAMINE - Abstract
Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same time, makes it possible for effective diabetic ulcers treatment. Co-delivery of multiple drugs with complementary bioactivity offers a strategy to properly treat diabetic wound. We previously demonstrated that hydroxysafflor yellow A (HSYA) could accelerate diabetic wound healing through promoting angiogenesis and reducing inflammatory response. In order to further enhance blood vessel formation, a pro-angiogenic molecular called deferoxamine (DFO) was topically co-administrated with HSYA. The in vitro results showed that the combination of DFO and HSYA exerted synergistic effect on enhancing angiogenesis by upregulation of hypoxia inducible factor-1 alpha (HIF-1α) expression. The interpenetrating polymer networks hydrogels, characterized by good breathability and water absorption, were designed for co-loading of DFO and HSYA aiming to recruit angiogenesis relative cells and upgrade wound healing in vivo. Both DFO and HSYA in hydrogel have achieved sustained release. The in vivo studies indicated that HSYA/DFO hydrogel could accelerate diabetic wound healing. With a high expression of Hif-1α which is similar to that of normal tissue. The noninvasive US/PA imaging revealed that the wound could be recovered completely with abundant blood perfusion in dermis after given HSYA/DFO hydrogel for 28 days. In conclusion, combination of pro-angiogenic small molecule DFO and HSYA in hydrogel provides a promising strategy to productively promote diabetic wound healing as well as better the repair quality. [ABSTRACT FROM AUTHOR]
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- 2018
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8. The impact of solar activity on the 2015/16 El Niño event.
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Wen-Juan HUO and Zi-Niu XIAO
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- 2016
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9. Insight into the key active sites of af ChiA1 based on molecular dynamics simulations and free energy calculations.
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Niu, Xiao D., Lv, Zhuo, Zhou, Xin R., and Wang, Hong S.
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CHITINASE , *MOLECULAR dynamics , *FREE energy (Thermodynamics) , *ASPERGILLUS fumigatus , *ALLOSAMIDIN , *ACETAZOLAMIDE - Abstract
In this study, the binding of the enzyme chitinase A1 (afChiA1) from the plant-typeAspergillus fumigatuswith four potent inhibitors, allosamidin (ASM), acetazolamide (AZM), 8-chloro-theophylline (CTP) and kinetin (KIT) is investigated by molecular docking, molecular dynamics simulation and binding free energy calculation. The results reveal that the electrostatic interactions play an important role in the stabilisation of the binding ofafChiA1 with inhibitors. Based on the binding energy ofafChiA1-ligands, the key residues (Gln37 and Trp312) in the active binding pocket of the complex systems are confirmed by molecular mechanics/Poisson–Boltzmann surface area method, and the active inhibitors, ASM and AZM, both could form strong interaction with Gln37 and Trp312, and the non-active ligands, CTP and KIT, could not interact with these two residues, which is consistent with the result of experimental report. Then, it is identified that Gln37 and Trp312 should be one of the important active site residues ofafChiA1. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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10. Altered bulbocavernosus reflex in patients with multiple system atrophy.
- Author
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Wang, Zhang-yang, Chen, Yun-hao, Xu, Ya-ya, Wang, Xun, Shao, Bei, Niu, Xiao-ting, Chen, Bi-cheng, and Huang, Huan-jie
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MULTIPLE system atrophy ,PARKINSONIAN disorders ,NEUROPHYSIOLOGY ,NEURODEGENERATION ,NEUROLOGICAL disorders - Abstract
Objectives: Multiple system atrophy (MSA) is characterized by a combination of symptoms including autonomic dysfunction, parkinsonism, cerebellar ataxia, and cortico-spinal disorders. The disease can have either predominant parkinsonism or cerebellar features (MSA-P and MSA-C, respectively). The measurement of the bulbocavernosus reflex (BCR) and pudendal nerve somatosensory-evoked potentials (PSEPs) was originally developed to diagnose diabetic cystopathy and other neuropathologic diseases that share similar symptoms with MSA. We investigated the relationship between abnormalities of neurophysiological parameters and MSA, and estimated the potential value of BCR. Methods: Fifty-one MSA patients (28 and 23 MSA-P and 23 MSA-C patients, respectively) and 30 healthy controls who were seen at the Department of Neurology were included in the study. A Keypoint EMG/EP system was used to test BCR and PSEPs, and the latencies and amplitudes were recorded for statistical analyses. Results: The BCR was elicited in 78.4% patients with MSA (22/28 MSA-P, 18/23 MSA-C). Prolonged BCR latencies were found in patients with MSA compared with healthy controls (p < 0.001). BCR amplitudes were significantly lower in the MSA group than the control group (p < 0.001). PSEP P41 amplitudes were not significantly different between the MSA and control groups in males (p = 0.608) or females (p = 0.897). There were no significant differences in PSEP latencies among the MSA-P, MSA-C, and control groups (p = 1.0, p = 0.263, and p = 0.060, respectively). Discussion: MSA patients exhibit prolonged BCR latencies and lower amplitudes, which provides a rough anatomical localization of nervous system lesions in MSA patients. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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11. DETERMINATION OF 2-UNDECANONE IN RAT PLASMA AND TISSUE BY A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD: AN APPLICATION FOR THE PHARMACOKINETIC AND TISSUE DISTRIBUTION RESEARCH.
- Author
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Li, Wei-Feng, Niu, Xiao-Feng, Zhang, Ji-Ye, Zhou, Ping, and He, Lang-Chong
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BLOOD plasma , *METHYL ketones , *HIGH performance liquid chromatography , *SAURURACEAE , *PHARMACOKINETICS , *TISSUES , *ULTRAVIOLET radiation , *STANDARD deviations , *LABORATORY rats - Abstract
The purpose of this study was to establish a reliable high performance liquid chromatography (HPLC) method to investigate the pharmacokinetic and tissue distribution profiles of 2-undecanone. A LC2010AHT HPLC system coupled with UV detector was employed and the separations were performed on a ZORBAX Extend C18analytical column. The mobile phase was a mixture of 50% acetonitrile and 50% water at a flow rate of 0.7 mL/min with isocratic elution. The method was validated within the concentration range 0.08–5.00 µg/mL for plasma samples, and 0.04–4.00 µg/g for tissue samples, the calibration curves were linear with correlation coefficients >0.99. The limit of detection (LOD) was 0.03 µg/mL or 0.02 µg /g (three times signal/noise ratio). Intra- and inter-day precisions expressed as the relative standard deviation (RSD) for the method were 1.95–3.89% and 2.43–4.23%, respectively. The method recoveries for all samples were >80%. The main pharmacokinetic parameters obtained were tmax = (0.32 ± 0.10) h, Cmax = (6.47 ± 1.91) µg/mL, AUC0→∞ = (9.81 ± 3.11) (µg/mL) · h, and Ka = (5.30 ± 1.73) · h−1. The concentrations of 2-undecanone in liver (5.50 ± 0.26 µg/g) and spleen (3.90 ± 0.22 µg/g) were higher than in the other investigated tissues. [ABSTRACT FROM PUBLISHER]
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- 2013
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12. Determination of the liquid crystals phase transition temperatures using optical rotation effect.
- Author
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Niu, Xiao-ling, Liu, Wei-guo, Liu, Peng, and Cai, Chang-long
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LIQUID crystals , *PHASE transitions , *OPTICAL rotation , *TEMPERATURE effect , *OPTICAL polarization , *CALORIMETRY , *MICROSCOPES - Abstract
Using optical rotation effect, a sensitive, simple optical analytical system is developed for determining the phase transition temperatures of liquid crystals (LCs). When a monochromatic polarized light passes through LCs sample and analyzer, the light intensity changes with temperature. Especially, during the phase transition process, the intensity varies greatly due to optical rotation effect. The variation of light intensity versus variation of temperature curve shows the phase transition temperatures of LCs clearly. The phase transition temperatures of three cholesteric liquid crystals (ChLCs) and a nematic liquid crystals (NLCs) were detected by this method, and compared with those of the differential scanning calorimetry (DSC) and polarized light microscope (PLM) methods. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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13. Expression of response gene to complement-32 in renal tissue of children with immunoglobulin A nephropathy.
- Author
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Niu, Xiao-Ling, Kuang, Xin-Yu, Zhang, Zhi-Gang, Liu, Xue-Guang, Zhao, Zhong-Hua, Zhang, Xin, Xu, Hong, and Huang, Wen-Yan
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GENE expression , *IMMUNOGLOBULIN A , *KIDNEY diseases , *JUVENILE diseases , *RENAL biopsy , *SMOOTH muscle , *IMMUNOHISTOCHEMISTRY - Abstract
Objective. This study aimed to investigate the expression and significance of response gene to complement-32 (RGC-32) in renal tissue of children with immunoglobulin A nephropathy (IgAN). Material and methods. Forty-five patients diagnosed as having IgAN by renal biopsy were enrolled. The expression of RGC-32, α-smooth muscle actin (α-SMA) and transforming growth factor-β1 (TGF-β1) was observed by immunohistostaining. The relationshis between the expression of RGC-32, α-SMA, TGF-β1, degree of renal pathological lesions in IgAN and clinical index were assessed by Spearman correlation. Results. Immunohistostaining analysis showed that RGC-32 protein was present in epithelial cells of renal tubules in normal and IgAN renal tissues. With more severe renal pathological lesions, the expression of RGC-32 in IgAN was increased. The expression of RGC-32 was positively correlated with that of α-SMA, TGF-β1 and the degree of renal pathological lesions in children with IgAN ( p < 0.05), but had no relationship with serum creatinine, urinary N-acetyl-β- d-glucosaminidase/creatinine, urinary microalbuminuria/creatinine, urinary microimmunoglobulin/creatinine or urinary α1-microglobulin/creatinine ratio ( p > 0.05). Conclusion. Expression of RGC-32 can reflect the degree of renal pathological lesions in IgAN. RGC-32 may participate in the renal tubulointerstitial lesions in children with IgAN, especially in epithelial -mesenchymal transition induced by TGF-β1. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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14. Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives.
- Author
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Wang, Li-Jun, Ye, Xiao-Li, Chen, Zhu, Li, Xue-Gang, Sun, Qing-Lei, Zhang, Bao-Shun, Cao, Xiao-Gang, Yu, Gang, and Niu, Xiao-Hua
- Subjects
BACTERIA ,ANTI-infective agents ,GRAM-positive bacteria ,STRUCTURE-activity relationships ,FUNGUS-bacterium relationships - Abstract
By introducing octyloxy to C-3 and alkyl groups to C-8 of jatrorrhizine, a series of 3-octyloxy-8-alkyljatrorrhizine derivatives were synthesized and their antimicrobial activities were evaluated in vitro. The results indicated that the derivatives exhibited high antimicrobial activities, especially against Gram-positive bacteria. The 3-octyloxy-8-butyljatrorrhizine displayed the highest antimicrobial activity in all compounds. Their structure-activity relationships were discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
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15. An irregular approach of right atrial lead placement in a patient with persistent left superior vena cava and concomitant agenesis of the right-sided superior vena cava.
- Author
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ZHANG, Jun-Bo, LYU, Ying, and NIU, Xiao-Lin
- Published
- 2014
- Full Text
- View/download PDF
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