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Thrombolysis in Myocardial Infarction Frame Count (TFC) is an index that provides a quantitative evaluation of coronary microvascular dysfunction. In this study, we aimed to examine the effect of COVID-19 infection on TFC in patients admitted with chest pain and dyspnoea after COVID-19 disease and had abnormal findings in myocardial perfusion scintigraphy. For this single-center retrospective study, patients with and without a history of COVID-19 who were underwent coronary angiography for abnormal findings in myocardial perfusion scintigraphy between January 1, 2021 and June 30, 2021 were analysed. Patients were divided into two groups as patients with COVİD-19 history and those without. After exclusion criteria, patients with adequate angiographic monitoring and data were included in the study. A total of 210 patients, 48 with a history of COVID-19, were included in the study. The mean age was ±55 10 years, and 122 (58%) patients were women. In patients with a history of COVID-19, TFC was significantly higher in the LAD (p < 0.001) and LCx (p < 0.001) arteries and RCA TFC (p = 0.223) was similar in both groups. In the linear mix model, male gender (β = 2.38, 95% CI = 1.26–3.51, p < 0.001) and history of COVID-19 (β = 1.51, 95% CI = 0.49–2.53, p = 0.004) were significantly associated with TFC. TFC may be elevated due to coronary microvascular dysfunction in patients with a history of COVID-19. [ABSTRACT FROM AUTHOR]

We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients. Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. The patient groups ACEI, ARB and other antihypertensive drugs (non-ACEI/ARB) were compared regarding same parameters. Median age was 68 (60–76) years in the patient group including 805 (59.9.1%) females. Of the patients, 475 (35.3%), 644 (47.9%) and 226 (16.8%) were using ACEIs, ARBs and non-ACEI/ARB, respectively. AHRF and in-hospital mortality developed in 1053 (78.3%) and 290 (21.6%) patients, respectively. Age, gender, coronary artery disease, diabetes mellitus (DM), neutrophil, lymphocyte, creatinine, D-dimer, C-reactive protein (CRP), ACEI, beta blocker and aspartate transaminase (AST) found statistically significant in the univariable logistic regression performed to identify independent predictors of mortality were included multivariable logistic regression model. Age (OR: 1.066, 95%CI: 1.049–1.083; p <.001), DM (OR: 1.682, 95%CI: 1.238–2.286; p =.001), neutrophil (OR: 1.041, 95%CI: 1.007–1.077; p =.019), creatinine (OR: 1.178, 95%CI: 1.048–1.325; p =.006), CRP (OR: 1.008, 95%CI: 1.006–1.010; p <.001), ACEI (OR: 0.718, 95%CI: 0.521–0.988; p =.042), AST (OR: 1.005, 95%CI: 1.001–1.010; p =.010) were found associated with in-hospital mortality. In our study, it was not detected clinically significant difference between three groups with regard to their relation with in-hospital mortality. [ABSTRACT FROM AUTHOR]

The article talks about the long term outcomes of atrial fibrillation catheter ablation (CA) and predictors of atrial fibrillation (AF) recurrence after CA. It mentions only left atrial diameter and early arrhythmia recurrence were found to be predictors of AF recurrence.

The article focuses on the Protein C acts a primary role in fibrinolysis and is synthesised from liver by vitamin K dependent pathways. It mentions Warfarin is vitamin K antagonist and inhibits the synthesis of vitamin K dependent clotting factors including factor II, VII, IX, X and the anticoagulant proteins C and S; and activated protein C has its own unique inhibitor, activated protein C inhibitor.