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It was designed to effectively target wild-type BCR-ABL1 and a wide range of BCR-ABL1 mutants, including T315I, making it a promising reinduction therapy for relapsed Ph + B-ALL. E255K, T315I, and a compound of T315I and Q252H mutations were identified in 3 BCR-ABL1 P210-positive patients, respectively, whereas no mutations were found in 2 BCR-ABL1 P190-positive patients. Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + B-ALL) was one of high risky B-cell ALL subtypes that exhibits resistance to conventional chemotherapy [[1]]. Moreover, the induction therapy for Ph + B-ALL evolved from TKI plus intensive chemotherapy to TKI plus corticosteroids, which also supported that TKI was the backbone for Ph + B-ALL treatments. [Extracted from the article]

Objective:This study aims to explore the clinical features of multiple myeloma (MM) and the influence of various prognostic factors on survival. Methods:A retrospective analysis, consisting of clinical characteristics analysis and laboratory examinations, was performed on 787 MM patients. Clinical and laboratory parameters were analyzed by multivariate process and compared across different groups. Results:Of the 787 patients enrolled (median age, 61 years old, range 29–89 years old), 491 (62.4%) were male. Two most common complaints were bone pain (51.2%) and fatigue (48.0%). Anemia (hemoglobin (Hb) ≤100 g/L in female, Hb ≤110 g/L in male) was present initially in 69.4% patients. IgG was the most common type (46.6%). 52.2% of the patients were diagnosed on stageIIIA according to Durie–Salmon (D–S) system, 44.6% are on stageIIIaccording to International Staging System (ISS). Multivariate analysis suggested that age, serum calcium, LDH, percentage of abnormal plasma cells in bone marrow were all independent prognostic factors for OS. Conclusion:The MM patients in China are relatively younger, have higher rate on stageIIIaccording to D–S system. Older age, high serum calcium, high LDH, high percentage of abnormal plasma cells in bone marrow were highly related to poor prognosis. [ABSTRACT FROM PUBLISHER]

T-cell lymphoma-associated hemophagocytic syndrome (T-LAHS) has been frequently reported in Asian countries and is considered with extremely poor prognosis. To summarize its clinical characteristics and explore its early diagnosis and treatment, we retrospectively analyzed the records of 113 patients with aggressive T cell lymphoma, of which 28 were associated with LAHS. According to WHO classification (2001), 22 cases were classified into peripheral T-cell lymphoma (unspecified), 2 into extranodal NK/T-cell lymphoma, and 4 into systemic anaplastic large cell lymphoma. The median survivals of the LAHS and no-LAHS groups were 40 days and 8 months, respectively. The elevating rates of serum lactate dehydrogenase (LDH) (100% vs. 55%), ferritin (100% vs. 64%), fasting triglycerides (79% vs. 43%), and hypofibrinogen (43% vs. 14%)levels were higher in the LAHS group than in the no-LAHS group (P < 0.05), so were bone marrow involvement (57% vs. 32%, P < 0.05)and liver dysfunction (40% vs. 13%, P < 0.05). Eleven of the 28 LAHS patients did not receive any chemotherapy, and 14 received CHOP regimen as initial chemotherapy. Three patients in critical conditions were given plasma exchange and gained the chance of initial chemotherapy. We suggest that in patients presenting with fever, hepatosplenomegaly, cytopenia, and constantly increasing levels of serum LDH, CA125, ferritin, transglutaminase, and β2-microglobulin, T-LAHS should be taken into account. Repeating biopsies of multiple parts of bone marrow may help diagnosis. The therapeutic result of chemotherapy alone or combined for T-LAHS was discouraging and the survival time of most cases was no more than 1 year. Plasmapheresis as initial therapy is worth considering in critical cases. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 16-year old non-smoking adolescent who presented with a one-month history of cough and fever. Computed tomography (CT) scan of the patient's chest revealed there was a mass inside the right main bronchus with increased density in the right lung hilum. The patient was diagnosed with polypoid mass which occluded the bronchus after fiberoptic bronchoscopy.

A letter to the editor is presented which discusses a familial mantle cell lymphoma in a mother and her daughter.