1. Antimicrobial oral lavage reduces the SARS-CoV-2 load in intubated patients: randomized clinical trial.
- Author
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Bezinelli, Letícia Mello, Corrêa, Luciana, Beyerstedt, Stephany, Rangel, Érika Bevilaqua, Benitez, Carlos, Hamerschlak, Nelson, Rebello Pinho, João Renato, Heller, Debora, and de Paula Eduardo, Fernanda
- Subjects
CLINICAL trials ,MOUTHWASHES ,SARS-CoV-2 ,INTUBATION ,VIRAL load - Abstract
Background: The oral cavity can be a reservoir for SARS-CoV-2 and may play a crucial role in the viral transmission in the hospital environment. Objective: To investigate whether an oral hygiene protocol with chlorhexidine (CHX) used alone and in combination with hydrogen peroxide (HP) in the intensive care unit was effective in reducing the SARS-CoV-2 viral load in the oral cavity. Methods: SARS-CoV-2 viral load was measured on oral fluid samples collected from patients undergoing orotracheal intubation. The study sample was randomly in: CHX group (n = 19) - oral rinse using only 0.12% CHX solution; HP+CHX group (n = 24) - oral rinse with 1.5% HP and 0.12% CHX. The samples were collected before the interventions (T0), immediately (T1), 30 minutes (T2) and 60 minutes (T3) after the procedure. Results: A significant viral load reduction was observed at T1 (mean ± SD:–0.57 ± 0.19 log10;– 73.2%;p = 0.022) in the HP+CHX group. No statistically significant differences between any time points were observed in the CHX group. Conclusion: The HP+CHX oral rinses significantly reduced the SARS-CoV-2 viral load in the oral fluid immediately after the procedure. The CHX oral rinse alone did not result in any significant viral load reductions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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