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This paper proposes a cascade high-gain observer for a class of triangular nonlinear systems with large and diverse time delays at states and output equation. Compared with some existing results in the literature, the main contribution is to consider the simultaneous and diverse delays in both states and output and further, to propose a cascade observer in dealing with arbitrarily large delayed measurements. By choosing a suitable Lyapunov-Krasovskii functional, the sufficient condition is presented that guarantees the exponential convergence of observation error to the origin. Simulation results on a numerical example and a practical case study involving inverted pendulum are finally given to illustrate the effectiveness of the proposed approach. [ABSTRACT FROM AUTHOR]