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The article reports on regression of systemic ALK (+) anaplastic large cell lymphoma carrying ALK gene rearrangement developed after purified protein derivative (PPD)tuberculin skin test. It states that due to development of lesion after PPD test, symptoms had resolved after lymph node excision and the patient shows no signs of disease progression. It mentions that tuberculin test antigens may result in an influx of T-lymphocytes and results in oncogenic nucleophosmin-ALK fusion protein.

A 31-year-old female with refractory extramedullary myeloid leukemia relapse underwent peripheral blood stem-cell transplantation from her HLA-identical brother. Hematopoietic recovery followed disappearance of the lesions. Studies three-months post-transplant showed complete chimerism (CC). Fourteen months after transplantation, the patient presented with an increasing number of extramedullary sites of biopsy-proven disease relapse (as nodular skin lesions). Bone marrow was in remission with maintenance of CC. However, tissue chimerism analysis showed full recipient-cell population. After one course of conventional dose chemotherapy followed by mobilized donorlymphocyte infusions (DLI), a complete response was achieved. DLI continued monthly but she developed new skin lesions accompanied by multiple cervical masses. Bone marrow and tissue chimerism revealed both recipient and donor cell population. We conclude that tissue chimerism analysis after DLI may not accurately document the cell origin. [ABSTRACT FROM AUTHOR]