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Human polyglutamine [poly(Q)] disorders such as Huntington's disease, different types of ataxias, etc. are devastating brain illnesses which are characterised by the presence of neurotoxic protein aggregates in the affected neurons. We have recently reported that S6K/4E-BP mediated growth promoting branch of insulin signalling pathway alleviates human poly(Q) induced neurotoxicity in Drosophila disease models. Since, the S6K/4E-BP sub-pathway can be stimulated by various amino acids; we extended our investigation to examine if oral feeding of amino acids delivers rescue against human poly(Q) toxicity in Drosophila. We utilised Drosophila models of two different poly(Q) disorders to test our hypothesis. Glutamine was fed to the test flies orally mixed in the food. Control and treated flies were then tested for different parameters, such as formation of poly(Q) aggregates and neurodegeneration, to evaluate glutamine's proficiency in mitigating poly(Q) neurotoxicity. Our study, for the first time, reports that glutamine feeding stimulates the growth promoting S6K/4E-BP branch of insulin signalling pathway and restricts pathogenesis of poly(Q) disorders in Drosophila disease models. We noted that glutamine treatment restricts the formation of neurotoxic poly(Q) aggregates and minimises neuronal deaths. Further, glutamine treatment re-establishes the chromatin architecture by improving the histone acetylation which is otherwise compromised in poly(Q) expressing neuronal cells. Since, the insulin signalling pathway as well as mechanism of action of glutamine are fairly conserved between human and Drosophila, our finding strongly suggests that glutamine holds immense potential to be developed as an intervention therapy against the incurable human poly(Q) disorders. [ABSTRACT FROM AUTHOR]

Major rice mills of Bangladesh are gradually running out from the paddy processing subsector, a serious concern for national food security. This study investigated the paddy drying methods of 22 rice mills to device a sustainable solution for major rice mills. Weather dependency and high sun drying time (48–96 hours) of paddy are responsible for low capacity utilization of major rice mills. Despite of high demand, appropriate dryer size for major rice mills was still unexplored. Present capacity utilization of major rice mills (27.6%) can be optimized to 72.5% with a 12 ton dryer. Analyzing drying mechanism of recirculating dryers, the study also proposed for a single dryer for both parboiled and aromatic paddy rather than following existing practice. This will make mechanical dryer affordable to major rice mill owners and new investors in this subsector. [ABSTRACT FROM AUTHOR]