1. Axitinib affects cell viability and migration of a primary foetal lung adenocarcinoma culture.
- Author
-
Menna, Cecilia, De Falco, Elena, Pacini, Luca, Scafetta, Gaia, Ruggieri, Paola, Puca, Rosa, Petrozza, Vincenzo, Ciccone, Anna Maria, Rendina, Erino Angelo, Calogero, Antonella, and Ibrahim, Mohsen
- Abstract
Fetal lung adenocarcinoma (FLAC) is a rare variant of lung adenocarcinoma. Studies regarding FLAC have been based only on histopathological observations, thus representative in vitro models of FLAC cultures are unavailable. We have established and characterized a human primary FLAC cell culture, exploring its biology, chemosensitivity, and migration. FLAC cells and specimen showed significant upregulation of VEGF165 and HIF-1α mRNA levels. This observation was confirmed by in vitro chemosensitivity and migration assay, showing that only Axitinib was comparable to Cisplatin treatment. We provide a suitable in vitro model to further investigate the nature of this rare type of cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF