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Dry-hopping, which is the cold, aqueous extraction of hops into beer, has gained popularity in recent years as a method for achieving intense hop aroma and flavor in beer. With some brewers dry-hopping at rates up to 2 kg/hL (∼5 lb/barrel), considerable waste is generated in terms of both beer loss and spent hops. The retention of valuable volatile and non-volatile hop components within spent hops, as well as their extraction into beer, was investigated on both a pilot and industrial scale. On the pilot scale (80 L), an unhopped pale ale was statically dry-hopped with differing lots of whole cone Amarillo®, Centennial, and Cascade at a rate of 386 g/hL (1 lb/bbl) for 24 h at 13 °C (55 °F). Spent hop material was also collected from a local brewery that dry-hopped ∼60 hL (50 bbl) of beer at a rate of 1,592 g/hL (4.125 lb/bbl). Approximately one-third of the dry-matter composition of hops was lost during dry-hopping regardless of hop variety; however, there was high retention of both α-acids (77% pilot scale, 52% industrial) and hop essential oil (51% pilot scale, 33% industrial). The oil remaining in the spent hops was enriched in hydrocarbon compounds and depleted in oxygenated compounds. These results indicate that spent dry-hops contain considerable brewing value and have the potential for re-use. [ABSTRACT FROM AUTHOR]

Hop cones (Humulus lupulusL.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop cones, was investigated. XN significantly attenuated ADP-induced blood platelet aggregation (97.2 ± 35.7 AU for 6 μg/ml of XNvs. 120.4 ± 30.1 AU for 0.17% dimethyl sulfoxide (DMSO),p < 0.001) and significantly reduced the expression of fibrinogen receptor (activated form of GPIIbIIIa) on platelets’ surface (47.6 ± 15.8 for 1.5 μg/ml XN, 44.6 ± 17.3% for 3 μg/ml XNvs. 54.5 ± 19.2% for control or 43.3 ± 18.4% for 6 μg/ml XNvs.49.7 ± 19.4% for 0.17% DMSO,p < 0.05 or less). These findings suggest that the phenolic compounds originating from hops (XN) have a novel role as antiplatelet agents and can likely be used as dietary supplements in prophylactic approaches. [ABSTRACT FROM AUTHOR]