1. Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters.
- Author
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Tauxe-Wuersch, Annick, De Alencastro, Luiz Felippe, Grandjean, Dominique, and Tarradellas, Joseph
- Subjects
TAMOXIFEN ,FLUOROURACIL ,INDUSTRIAL wastes ,DRUG therapy ,CANCER ,MASS spectrometry - Abstract
Tamoxifen and 5-fluorouracil are widely used in cancer therapy. They are highly toxic (teratogenic, mutagenic, etc.), as are most of the anticancer drugs. Two methods were set up to analyse these drugs in wastewaters to evaluate the potential for environmental contamination by cytostatic agents. Liquid–liquid extraction followed by purification on OASIS® MCX cartridge and gas chromatography with mass spectrometry detection (GC-MS) was used for the analysis of tamoxifen. 5-Fluorouracil was extracted with an ENV+  (Isolute) cartridge (solid-phase extraction), derivatized with pentafluorobenzyl bromide (PFBBr) and detected by GC-MS. Both methods showed good recoveries (>70%), repeatability (RSD [ABSTRACT FROM AUTHOR]
- Published
- 2006
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