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Dramatic changes in the social economic environment have made companies place more emphasis on integrating social media into their overall marketing strategy. Many features of social media commerce will be developed as tactics to implement social network marketing strategy. Enterprises increasingly need to develop an innovative and effective approach to social media in order to be competitive. With the right new service development phase, companies can gain competitive advantage in service-driven markets. The present study aims to refine a multi-service design for the case study company - MOS Burger. It examines the implementation of a new geo-social networking solution, and the application of the theory of inventive problem-solving (TRIZ). In the problem definition stage, the research analyzes the problems faced by the enterprise. In the service resolution stage, the contradiction analysis and 40 inventive principles are used to examine the prior process of ordering meals, to establish the principles for problem resolution. In the solution evaluation stage, new geo-social network solutions, MOS-Wish and MOS-Order mobile Apps, are proposed using the principles generated in the second stage. This study also evaluates service performance to compare the efficiency of prior model and new model of ordering and interaction with clients. [ABSTRACT FROM AUTHOR]

Objective: To elucidate the relationship of oxidative stress and specificity protein 1 (Sp1) in the process of epithelial-to-mesenchymal transdifferentiation (EMT) and also to investigate the molecular mechanism of protective effect of probucol on the pathogenesis of diabetic kidney disease (DKD). Methods: Thirty male Sprague-Dawley (SD) rats were randomly divided into control group, diabetic group, and diabetic group under probucol therapy ( n = 10 per group). The biochemical indicators including 24-h urinary total protein (24-h UTP) excretion, blood glucose (BG), lipids [triglycerides (TGs), total cholesterol (TC)], serum creatinine (Scr), creatinine clearance rate (Ccr), kidney tissue malondialdehyde (MDA) level, and glutathione peroxidase (GSH-Px) activity were assessed in all groups. The renal pathological changes were evaluated by hematoxylin and eosin (HE) and Masson staining. The protein expression of Sp1, α-smooth muscle actin ( α-SMA), and E-cadherin was also measured and analyzed by immunohistochemistry and Western blotting. Results: Compared with the control group, the BG, TC, Scr, 24-h UTP, and MDA level of renal tissue increased significantly and the Ccr reduced in the rats of diabetic group (all p < 0.01). The pathological scores and the expression of Sp1 and α-SMA in renal tissue were up-regulated ( p < 0.01) and the expression of E-cadherin was down-regulated significantly in the diabetic animals ( p < 0.01). In the diabetic animals treated with probucol, the renal injuries were alleviated ( p < 0.01). Conclusions: Oxidative stress may play an important role in the EMT process of tubular epithelial cells. Probucol could ameliorate renal disease progression in this model of diabetic nephropathy, which might be due to an antioxidant action, down-regulation of Sp1 protein expression, and inhibition of renal tubular EMT. [ABSTRACT FROM AUTHOR]

Objective. A prior report suggested that individuals medicated with captopril showed a decreased incidence of prostate cancer. This study therefore investigated whether captopril given postoperatively had any preventive effect on biochemical recurrence for patients treated with radical prostatectomy. Material and methods. Data were prospectively reviewed for 62 men subjected to radical retropubic prostatectomy due to biopsy-confirmed, clinically localized prostate cancer and comparisons were made between two groups, those receiving captopril postoperatively (12.5 mg twice daily; captopril group, n=32) and those not receiving any captopril (control group, n=30). One surgeon carried out the surgery. Results. The two groups were comparable as regards age at surgery, prostate volume, preoperative prostate-specific antigen values, pathological stage, Gleason score, organ-confined disease, occurrence of positive surgical margins and extraprostatic extension. The incidence of biochemical failure was three out of 32 patients in the captopril group and 10 out of 30 in the control group (p=0.034) during a mean observational time of 29 months. Conclusions. A lower rate of biochemical recurrence was observed in men subjected to radical prostatectomy treated with captopril postoperatively than in those not receiving captopril. These results were based on only 32 observations; a larger study may show no evidence of an association. [ABSTRACT FROM AUTHOR]