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This meta-analysis examined the predictive value of admission serum and urine carboxypeptidase-B activation peptide (CAPAP) in patients with severe acute pancreatitis. PubMed, Embase, and the Cochrane Library were searched for relevant studies published up to February 21, 2022. Seven studies (439 acute pancreatitis patients) were included. The summary sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), the area under the receiver operating characteristic curve (AUC) of admission serum CAPAP were 0.86 (95%CI: 0.76-0.93), 0.78 (95%CI: 0.68-0.85), 3.89 (95%CI: 2.56-5.91), 0.18 (95%CI: 0.09-0.33), 18.56 (95%CI: 6.99-49.30), and 0.90 (95%CI: 0.87-0.92), respectively; these values for admission urine CAPAP were 0.82 (95%CI: 0.50-0.95), 0.78 (95%CI: 0.68-0.86), 3.75 (95%CI: 2.40-5.85), 0.23 (95%CI: 0.07-0.79), 9.87 (95%CI: 3.71-26.22), and 0.84 (95%CI: 0.80-0.87), respectively. There were no significant differences between admission serum and urine CAPAP in sensitivity (1.05, 95%CI: 0.75-1.47; P = 0.781), specificity (1.00, 95%CI: 0.85-1.18; P = 1.000), PLR (1.04, 95%CI: 0.56-1.91; P = 0.906), NLR (0.78, 95%CI: 0.20-3.10; P = 0.727), and DOR (1.88, 95%CI: 0.47-7.49; P = 0.370). The AUC of serum CAPAP (1.07, 95%: 1.02-1.13; P = 0.007) was higher than that of urine CAPAP in predicting acute pancreatitis severity. Both admission serum and urine CAPAP had moderate predictive values for assessing the severity of acute pancreatitis. [ABSTRACT FROM AUTHOR]

This article collected papers published by Chinese archaeologists in Chinese and World core journals (CCJs and WCJs for short) in the past century. Based on bibliometric analysis, the general characteristics and trends of Chinese archaeology were summarized. In a macroscopic perspective, historiography-rooted archaeology focusing on historical periods and central areas of China and preferring traditional archaeological methods (mainly a culture-historical paradigm) will continue to occupy a leading position in China. Simultaneously, interdisciplinary research and internationalisation will likely continue to develop and diversify Chinese archaeology, though the speed is unknown due to the impact of the pandemic. In comparison, more attention needs to be paid to theoretical research and to publishing more results of historical archaeology in WCJs. [ABSTRACT FROM AUTHOR]

Clinical manifestations of hypereosinophilic syndrome (HES) are diverse. This study aimed to summarise these clinical characteristics with asthma-like onset as the first symptom, and compare these characteristics and treatment strategies between idiopathic and parasitic HES. We retrospectively analysed 36 HES patients with asthma-like symptoms as the first episode, between January 2013 and October 2019. Data of patients with HES of an unknown cause (idiopathic HES) and parasitic infection (parasite HES) were analysed. The idiopathic and parasite HES groups included 16 and 20 patients, respectively, with more males in the parasite HES group (p <.05). Wheezing and dry rales was the most common symptom and signs, with no significant differences in symptoms and signs between the groups. The most often misdiagnosed disease was bronchial asthma. The peripheral blood eosinophil count was significantly increased compared with normal counts in both groups (p >.05). Abnormal pulmonary function is mainly manifested as obstructive ventilatory disorder and mixed ventilatory disorder. Chest computed tomography showed extensive ground-glass exudation, patches, consolidation, nodules, and pleural effusion. Histopathological examination showed eosinophilic infiltration without vasculitis or granuloma. Glucocorticoids had a significant therapeutic effect, and the parasite HES group required combined deworming drugs. The duration of corticosteroids therapy in the idiopathic HES group was significantly longer than that in the parasite HES group (p <.05). The overall prognosis was good, and 81.25% of the patients were clinically cured in the parasite HES group; however, relapse occurred easily in the idiopathic HES group. Asthma-like symptoms, obstructive ventilatory disorder or positive bronchial dilation test, and poor response to inhaled corticosteroids are not necessarily indicative of refractory asthma; HES should be considered. The clinical characteristics of HES of different aetiologies are similar. Systemic corticosteroid therapy is preferred for idiopathic and parasitic infections. Idiopathic HES is treated with prolonged corticosteroids and relapses easily. Asthma-like symptoms, obstructive ventilatory disorder or positive bronchial dilation tests, and poor responses to inhaled corticosteroids are not necessarily indicative of refractory asthma, and hypereosinophilic syndrome should be considered. The clinical characteristics of hypereosinophilic syndrome of different aetiologies are similar, and systemic glucocorticoid therapy is preferred for both idiopathic and parasitic infections. Idiopathic hypereosinophilic syndrome is treated with prolonged corticosteroids and relapses easily. [ABSTRACT FROM AUTHOR]

The complete mitochondrial genome (mitogenome) of Miroplana shenzhensis Yu & Wang, 2013 is reported in the present study, representing the second mitogenome recorded in the suborder Maricola. The circular mitogenome is 14,344 bp in length, containing 12 protein-coding genes, 2 ribosomal RNAs and 22 transfer RNAs. Comparative analysis on mitochondrial gene order reveals a rearrangement in the suborder Maricola, indicating that mitochondrial gene order is conserved only in Continenticola, and is divergent across Tricladida. Phylogenetic analysis shows M. shenzhensis is clustered with an another marine triclad, forming a well-supported monophyletic group of Maricloan. [ABSTRACT FROM AUTHOR]

The present paper describes two new Chinese species of maricolan planarians through an integrated approach, including morphological, histological and molecular phylogenetic analyses. One new species forms the third species of the genus Pacifides and represents the first record of this genus from the Western Pacific. Further we document a third, new species of the genus Paucumara that is fully restricted to freshwater habitats, as it occurs on the shores of the Jialing River in Chongqing municipality far into the interior of China. Molecular phylogenetic analyses enabled us to determine, for the first time, the position of the genus Pacifides in the phylogenetic tree of the marine triclads. We also provide information on the feeding and reproduction of the new species of Pacifides. The paper concludes with two speculative scenarios on the evolutionary history that may have led to the present-day far inland occurrence and freshwater ecology of the new species of Paucumara; one scenario involves tectonic uplift-driven speciation and niche evolution, while the other invokes passive upstream dispersal via the Yangtze River. [ABSTRACT FROM AUTHOR]

This paper presents an empirical analysis of return migrants' entrepreneurial decisions after returning home using individual survey data in Jiangxi Province. We apply an extended hurdle model to investigate how social-economic factors, in particular, social network, local government support and previous migration experience may play different roles in affecting return migrants' entrepreneurial decisions in different stages. A standard probit model is incorporated in the first stage to separate potential return migrant entrepreneurs from those who are not willing to consider establishing enterprises. In the second stage, a lognormal hurdle model is used to identify factors affecting return migrants' entrepreneurial establishment and investment amount decisions. Results from the extended hurdle model suggest that government policy support is the most important factor for successfully attracting return migrant entrepreneurs back in Jiangxi Province. In addition, previous migration experience and household attributes are crucial and play different roles in affecting both return migrants' willingness to consider entrepreneurship decisions and entrepreneurial investment decisions. On the other hand, individual characteristics are shown to affect only return migrants' entrepreneurial investment decisions but not willingness to consider entrepreneurship decisions. [ABSTRACT FROM AUTHOR]

To investigate the effect of varying the light intensity on the photosynthate distribution, cherry tomato (Solanum lycopersicum L.) seedlings were grown under different light intensities. It was found that the seedlings under 300 μmol m–2 s–1 had a significantly higher dry weight and health index (Health index = Stem diameter/Stem height × Dry weight) than seedlings receiving other light treatments. On the contrary, the biomass, specific leaf mass and health index values of seedlings exposed to 50 μmol m–2 s–1 and 550 μmol m–2 s–1 were the lowest among all of the treatments. In terms of 14C-labelled photosynthate translocation, the seedlings under 300 μmol m–2 s–1 had lower remaining 14C-labelled photosynthate (31.45%) compared with other treatments, after 14CO2 was supplied for 2 days. The seedlings under 150 μmol m–2 s–1 had 36.97% of 14C-labelled photosynthate in the labelled leaves and transported the obviously higher 14C-labelled photosynthate to new shoot than others. Together, our results indicate that the photosynthate distribution was the most rational in cherry tomato seedlings at 300 μmol m–2 s–1, which enhanced leaf photosynthesis and plant growth. [ABSTRACT FROM AUTHOR]

This article reviews spectral unmixing used as a new method for Raman imaging. Raman spectroscopy explores the vibrational information about specific chemical bonds in molecules, which can be used for label-free molecular visualization. However, chemical bonds are usually shared among different molecules, which results in closed or mixed Raman peaks of many molecules. Therefore, the acquired spectra cannot be directly used to reconstruct the Raman images, as pure component spectra are hidden under the acquired spectra. Spectral unmixing is an effective method to provide a meaningful spectrum of each component with no priori spectral information and to also reconstruct the compositional distribution images. This article summarizes some representative spectral unmixing approaches used for Raman imaging and many related researches. This review strives to introduce the combination of spectral unmixing and Raman imaging as an efficient analytic technique to characterize various constituents and make subtle understanding of those complex structures. [ABSTRACT FROM PUBLISHER]

With the intensive development of large-scale livestock industry, the gas emissions from livestock farms were identified as a major problem. Many greenhouse gases and odorous gases are generated from animal exhalation, ruminant fermentation, livestock waste, and other factors. Considering the environmental impact brought by pollutant gas emissions, it is important to determine how it contributes to total emissions accurately in order to minimize it. This article gives a comprehensive overview over the non-spectroscopic techniques and spectroscopic techniques applied to air quality assessment in livestock. In addition, this review summarizes interferences in the detection process, emphasizing different interference reduction approaches for improving the performance of current detection technologies used in livestock farms. [ABSTRACT FROM PUBLISHER]

This study examined how shoe midsole hardness influenced plantar pressure in basketball-related movements. Twenty male university basketball players wore customized shoes with hard and soft midsoles (60 and 50 Shore C) to perform four movements: running, maximal forward sprinting, maximal 45° cutting and lay-up. Plantar loading was recorded using an in-shoe pressure measuring system, with peak pressure (PP) and pressure time integral (PTI) extracted from 10 plantar regions. Compared with hard shoes, subjects exhibited lower PP in one or more plantar regions when wearing the soft shoes across all tested movements (Ps < 0.05). Lower PTI was also observed in the hallux for 45° cutting, and the toes and forefoot regions during the first step of lay-up in the soft shoe condition (Ps < 0.05). In conclusion, using a softer midsole in the forefoot region may be a plausible remedy to reduce the high plantar loading experienced by basketball players. [ABSTRACT FROM AUTHOR]

Objectives. Tadalafil, an oral phosphodiesterase type-5 inhibitor, induces pulmonary vasorelaxation by inhibiting the breakdown of cyclic guanosine monophosphate whereas simvastatin, an oral 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor, has been shown to reverse pulmonary hypertension (PH) and attenuate vascular remodeling in animal models of pulmonary hypertension. We investigated whether the combination of tadalafil and simvastatin, which has different mechanisms of action, is superior to either drug alone in a rat model of monocrotaline-induced PH. Methods. Male Sprague-Dawley rats were randomized to gavage with a vehicle, tadalafil (10 mg/kg/day), simvastatin (2 mg/kg/day), or tadalafi + simvastatin 21 days after the monocrotaline (60 mg/kg) injections. The hemodynamic and histological changes in the pulmonary arterioles, right heart hypertrophy, interleukin 6 (IL-6) levels and perivascular inflammation in the lungs were measured 35 days after monocrotaline exposure. Results. The combination of tadalafil and simvastatin showed significantly more improvement in the mean pulmonary hypertension pressure (mPAP) and right ventricular hypertrophy compared with each monotherapy (p < 0.05). Combination therapy had additive effects on the increases in lung IL-6 levels and the perivascular inflammation score. Conclusions. These results suggest that the combination of tadalafil and simvastatin bears promise as an approach to treat PH, especially PH associated with inflammation. [ABSTRACT FROM AUTHOR]

Flavonoids have been recognised as having antitumour activity for years, although the precise mechanism of this activity is not known. In this study, we used the quantitative structure–activity relationship (QSAR), a method of computer simulation, to investigate this mechanism. The heuristic method (HM), support vector machine (SVM) and gene expression programming (GEP) were employed to build the QSAR models between antitumour activity (i.e. survival percentage) of a series of flavonoids and five molecular descriptors derived from the CODESSA. The GEP, which was used for the first time to predict the antitumour activity of flavonoids, was found much more accurate than the HM and the SVM. The descriptors involved in the models are mainly electrical related, and the quantum chemical factors relevant to the oxygen atom may play an important role in antitumour activity of flavonoids. These models may provide helpful information for designing novel antitumoural compounds with higher bioactivity. [ABSTRACT FROM PUBLISHER]

Heme oxygease-1 (HO-1) is the rate-limiting enzyme in heme catabolism. Induction of HO-1 has been shown to have vasodilatory, anti-inflammatory, and proapoptotic effects. More recently, experimental studies suggested the potential of simvastatin as a novel therapy for pulmonary hypertension (PH); however, the underlying mechanism remains to be investigated. The aim of this study was to evaluate whether HO-1 is required for the pulmonary vascular protective effects of simvastatin. Simvastatin (2 mg/kg/day) was administered once daily to rats for 4 weeks after monocrotaline (MCT) injection. Zn-protoporphyrin (Znpp), a potent inhibitor of HO, was used to confirm the role of HO-1. The hemodynamic changes, right heart hypertrophy, interleukin-6 (IL-6) level, and HO-1 protein expression in lungs were measured at day 28. Simvastatin significantly ameliorated mean pulmonary arterial hypertension (20.6 mm Hg). In addition, perivascular infiltration of inflammatory cells and the level of IL-6 were decreased in simvastatin treatment group. Simvastatin also increased significantly lung HO-1 protein expression. Inhibiting HO-1 using Znpp resulted in a loss of the effect of simvastatin in MCT rats. These results suggest that HO-1 expression is critical for the vascular protective effects of simvastatin in MCT-induced PH rats. [ABSTRACT FROM AUTHOR]