1. Virologic failure and all-cause mortality among older people living with HIV/AIDS in South China.
- Author
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Zhu, Qiuying, Huang, Jinghua, Wu, Xiuling, Chen, Huanhuan, Shen, Zhiyong, Xing, Hui, Shao, Yiming, Ruan, Yuhua, Zhang, Xiangjun, and Lan, Guanghua
- Subjects
HIV infections ,HIV-positive persons ,CONFIDENCE intervals ,VIRAL load ,MULTIPLE regression analysis ,TENOFOVIR ,AGE distribution ,ANTIRETROVIRAL agents ,RETROSPECTIVE studies ,TREATMENT effectiveness ,TREATMENT failure ,RISK assessment ,T-test (Statistics) ,SEX distribution ,CD4 lymphocyte count ,CHI-squared test ,RESEARCH funding ,ODDS ratio ,DATA analysis software ,MARITAL status ,AIDS ,LONGITUDINAL method ,PROPORTIONAL hazards models ,EDUCATIONAL attainment ,AIDS patients ,OLD age - Abstract
This retrospective cohort study investigated older people living with HIV/AIDS (PLWHA) characteristics, HIV care, and treatment outcomes among all cases between 1996 and 2019 in Guangxi, China. Secondary data were extracted from two national surveillance databases. Older (≥50 years old) and younger (18-49 years old) PLWHA were compared regarding demographic and behavioral characteristics, HIV care, virologic failure, and all-cause mortality. Older PLWHA accounted for 41.6% of all HIV cases (N = 144,952) between 1996 and 2019. The proportion of older cases increased from 10.4% to 64.8% for men and from 2.4% to 66.7% for women between 2002 and 2019. Heterosexual contact accounted for 96.0% of older adults. Moreover, older PLWHA had a lower median CD4 count at the HIV diagnosis (193 vs. 212 cells/μL, p < 0.0001) and were less likely to receive antiretroviral therapy (ART) than younger adults (72.1% vs. 86.1%, p < 0.001). The all-cause mortality risk of older PLWHA was 2.87 times of younger adults [adjusted hazard ratio (AHR) 2.87; 95% confidence interval (CI) 2.76-2.98]. In addition, older PLWHA reported an 18% increase in odds for virologic failure than younger adults (AOR 1.18; 95% CI 1.08-1.30). Therefore, enhanced HIV prevention and care are urgently needed in older people. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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