110 results on '"Yang, Shiming"'
Search Results
2. Changes in hearing function and intracochlear morphology after electrode array insertion in minipigs.
- Author
-
Du, Haiqiao, Li, Jianan, Chen, Zhifeng, Gao, Yun, Yang, Xiao, Yuan, Shuolong, Wang, Qian, Guo, Weiwei, Chen, Wei, Dai, Pu, and Yang, Shiming
- Subjects
COCHLEAR implants ,BIOLOGICAL models ,SWINE ,RESEARCH funding ,ARTIFICIAL implants ,ANIMAL experimentation ,HEARING ,ELECTRODES - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
3. Study of the factors related to air-bone gap in enlarged vestibular aqueduct.
- Author
-
Wang, Rong, Zhuang, Bo-xiang, Guo, Weiwei, Li, Jianan, Lin, Chang, and Yang, Shiming
- Subjects
RISK assessment ,STATISTICAL correlation ,BIOMECHANICS ,VESTIBULAR aqueduct ,CONDUCTIVE hearing loss ,RESEARCH funding ,DESCRIPTIVE statistics ,AGE distribution ,SEVERITY of illness index ,VESTIBULAR apparatus diseases ,RESEARCH ,SEQUENCE analysis ,GENETICS ,DISEASE risk factors ,DISEASE complications - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
4. Analysis of the effectiveness of hearing solutions for congenital malformation of the middle and outer ear (CMMOE).
- Author
-
Jin, YingYu, Zhang, HongJia, Zhang, Ming, Wang, QingSen, Yang, ShiMing, and Zou, YiHui
- Abstract
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
5. Precise selection of bone conduction hearing devices for congenital malformation of the middle and outer ear (CMMOE).
- Author
-
Zou, YiHui, Wang, QingSen, Liu, Chang, Ren, LiYao, Sun, XiuLi, and Yang, ShiMing
- Abstract
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
6. Study of hearing features of Congenital Malformation of the Middle and Outer Ear (CMMOE).
- Author
-
Duan, XiaoHan, Wang, QingSen, Wang, Ting, Sun, BaoChun, Yang, ShiMing, and Zou, YiHui
- Abstract
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
7. The characteristics of hearing loss in outpatients with tinnitus over the age of 60: a 11-year cross-sectional study.
- Author
-
Xia, Qingqing, Yang, Shiming, and Ji, Fei
- Subjects
- *
TINNITUS , *CONFIDENCE intervals , *PRESBYCUSIS , *CROSS-sectional method , *RETROSPECTIVE studies , *T-test (Statistics) , *SYMPTOMS , *DESCRIPTIVE statistics , *RESEARCH funding , *AUDIOMETRY , *DATA analysis software , *OUTPATIENTS - Abstract
Presbycusis with tinnitus has a significant impact on the quality of life of elderly patients, becoming a serious socioeconomic problem. We conducted an 11-year cross-sectional analysis of the audiometry results of elderly patients with tinnitus from 2011 to 2021. 9642 patients aged 60 and over were divided into three groups: young-old (YO) (60–74), old–old (OO) (75–89), and longevous (LON) (90 and over). Pure-tone audiometry results of all patients were analyzed. Among 9642 patients, the cases of female with tinnitus were more than male in all years. The hearing curve showed a typical age-related decline. Hearing level of air conduction in female declined significantly at low frequencies while that of male was worse at high frequencies in YO and OO groups. Compared with right, left hearing level of air conduction was significantly decreased at all frequencies except 0.125 kHz. When the chief complaint was tinnitus, women were likely to experience more distress than men. However, men suffered from more hearing loss than women, at least in high frequencies. The influence weight of presbycusis and tinnitus on the auditory cortices might be a possible reason for the lateral distinction of hearing loss at different ages. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Political economy of vaccine diplomacy: explaining varying strategies of China, India, and Russia's COVID-19 vaccine diplomacy.
- Author
-
Suzuki, Mao and Yang, Shiming
- Subjects
- *
COVID-19 vaccines , *VACCINATION , *COVID-19 pandemic , *DIPLOMACY , *VACCINES , *DIPLOMATS , *CRISIS communication - Abstract
The COVID-19 pandemic and global responses to this crisis reveal the changing landscape of global health governance. As countries around the world struggle to secure COVID-19 vaccines for their citizens, some non-Western powers have actively distributed vaccines internationally – an act broadly recognized as vaccine diplomacy. While existing literature suggests that geopolitical concerns affect the selection of recipient countries, it has yet to explain other aspects of vaccine diplomacy. Why are some countries focused on vaccine sales while others are more open to donation? Why do some prefer bilateral to multilateral channels in distributing vaccines? Through comparative analysis of China, India, and Russia, this article shows that political economic factors, in addition to geopolitics, shape the ways non-Western powers conduct vaccine diplomacy. We argue that these countries adjust their strategies in line with their relative advantages in development, manufacturing, and delivery of vaccines. Each country has unique strengths and weakness, which gives rise to the varied patterns in vaccine diplomacy. Our findings suggest that their strategies of vaccine diplomacy are enabled as well as constrained by their economic realities, and the rise of these countries in this field does not necessarily mean an outright challenge to the existing international system. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
9. Ferroptosis inhibition shields house ear institute-organ of corti 1 cells from free fatty acids-induced inflammatory injuries.
- Author
-
Chen, Xuemin, Yu, Yiding, Yu, Ning, Guo, Weiwei, Jiang, Qingqing, and Yang, Shiming
- Subjects
CYTOKINES ,INTERLEUKINS ,GRANULOCYTE-macrophage colony-stimulating factor ,COCHLEA ,GRANULOCYTE-colony stimulating factor ,INFLAMMATION ,CELL survival ,RESEARCH funding ,OTOTOXICITY ,LACTATE dehydrogenase ,WOUNDS & injuries ,REACTIVE oxygen species ,IRON overload ,INFLAMMATORY mediators ,CELL death ,FATTY acids ,GLUTATHIONE peroxidase ,TOLL-like receptors - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
10. Imaging features, staging system, and surgical management of giant cell lesions of the temporal bone.
- Author
-
Li, Xiaohong, Wen, Yi, Zhang, Jie, Wu, Nan, Shen, Weidong, Yang, Shiming, Dai, Pu, Han, Dongyi, Yang, Yang, Han, Weiju, Feng, Bo, and Wang, Guojian
- Subjects
TEMPORAL bone surgery ,GIANT cell tumors ,RETROSPECTIVE studies ,MAGNETIC resonance imaging ,CANCER relapse ,BONE tumors ,DIAGNOSTIC imaging ,RISK assessment ,SYMPTOMS ,DESCRIPTIVE statistics ,COMPUTED tomography ,TEMPORAL bone ,DISEASE risk factors - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
11. Morphology changes in the cochlea of impulse noise-induced hidden hearing loss.
- Author
-
Qi, Guowei, Shi, Lei, Qin, Handai, Jiang, Qingqing, Guo, Weiwei, Yu, Ning, Han, Dongyi, and Yang, Shiming
- Subjects
STATISTICS ,AUDITORY evoked response ,COCHLEA ,ANALYSIS of variance ,ANIMAL experimentation ,HIDDEN hearing loss ,T-test (Statistics) ,DESCRIPTIVE statistics ,NOISE-induced deafness ,DATA analysis software ,DATA analysis ,GUINEA pigs ,BRAIN stem - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
12. Characteristics of hearing loss in elderly outpatients over 60 years of age: an annual cross-sectional study.
- Author
-
Li, Siyang, Ye, Hui, Chen, Aiting, Lan, Lan, Yang, Shiming, and Ji, Fei
- Subjects
DEAFNESS prevention ,TREATMENT of hearing disorders ,CROSS-sectional method ,AGE distribution ,PRESBYCUSIS ,SEVERITY of illness index ,SOCIOECONOMIC factors ,HEARING disorders ,SYMPTOMS ,AUDIOMETRY ,DESCRIPTIVE statistics - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
13. Electrophysiological and histomorphological changes of cochlea in miniature pigs after abrasion of round window niches.
- Author
-
Liu, Qian, Guo, Weiwei, Yang, Shiming, Ji, Xiaojun, Lin, Chang, and Chen, Wei
- Subjects
COCHLEAR implants ,EVOKED response audiometry ,AUDITORY evoked response ,COCHLEA ,HAIR cells ,ANIMAL experimentation ,SWINE ,ELECTROPHYSIOLOGY ,BRAIN stem - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
14. Application of a novel transcanal keyhole technique in endoscopic cholesteatoma surgery.
- Author
-
Hou, Zhaohui, Wang, Fangyuan, Zuo, Wenjing, Liu, Ya, Wang, Wenjia, Hou, Kun, Jia, Jianping, and Yang, Shiming
- Subjects
EAR surgery ,PREOPERATIVE care ,RETROSPECTIVE studies ,CHOLESTEATOMA ,DISEASE relapse ,DIAGNOSTIC imaging ,ADVERSE health care events ,ENDOSCOPY ,PATIENT safety - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
15. Identification of factors associated with tinnitus outcomes following the microsurgical treatment of vestibular schwannoma patients.
- Author
-
Zhang, Chi, Wang, Fangyuan, Cao, Wei, Ma, Xiaoyan, Chen, Jiyue, Shen, Weidong, and Yang, Shiming
- Subjects
TINNITUS ,EAR surgery ,HEARING ,MICROSURGERY ,PREOPERATIVE period ,INNER ear ,RETROSPECTIVE studies ,TREATMENT effectiveness ,POSTOPERATIVE period ,AUDIOMETRY ,ACOUSTIC neuroma ,EVALUATION - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
16. Air and bone-conducted vestibular evoked myogenic potentials in children with large vestibular aqueduct syndrome.
- Author
-
Liu, Xuhui, Ren, Lili, Li, Jianan, Ji, Fei, Liu, Xingjian, Du, Yi, Guo, Weiwei, Wu, Ziming, and Yang, Shiming
- Subjects
AUDITORY evoked response ,BONE conduction ,COMPARATIVE studies ,HEARING ,VESTIBULAR apparatus diseases ,LOGISTIC regression analysis ,DESCRIPTIVE statistics ,VESTIBULAR aqueduct - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
17. The characteristics of vHIT gain and PR score in peripheral vestibular disorders.
- Author
-
Du, Yi, Ren, Lili, Liu, Xingjian, Guo, Weiwei, Wu, Ziming, and Yang, Shiming
- Subjects
COMPARATIVE studies ,SACCADIC eye movements ,VERTIGO ,VESTIBULAR apparatus diseases ,VESTIBULAR function tests ,RETROSPECTIVE studies ,DISEASE progression ,DATA analysis software - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
18. Scutum reconstruction technique and classification in endoscopic middle ear cholesteatoma surgery.
- Author
-
Wu, Nan, Zuo, Wenjing, Wang, Fangyuan, Hou, Kun, Yang, Shiming, and Hou, Zhaohui
- Subjects
MIDDLE ear surgery ,CARTILAGE ,CHOLESTEATOMA ,EAR ,EAR surgery ,ENDOSCOPY ,HEARING ,MASTOID process ,PLASTIC surgery ,DISEASE relapse ,TREATMENT effectiveness - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
19. The impact of stapes surgery on osteogenesis imperfecta: a retrospective comparison of operative outcomes with those for patients with otosclerosis.
- Author
-
Ma, Xiaoyan, Wang, Fangyuan, Shen, Weidong, and Yang, Shiming
- Subjects
TREATMENT of hearing disorders ,AUDIOMETRY ,EAR surgery ,HEARING ,PATIENT aftercare ,OSTEOGENESIS imperfecta ,OTOSCLEROSIS ,TREATMENT effectiveness - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
20. Analysis on the correlation between Eustachian tube function and outcomes of type I tympanoplasty for chronic suppurative otitis media.
- Author
-
Li, Ruixiang, Wu, Nan, Zhang, Jiabing, Hou, Zhaohui, and Yang, Shiming
- Subjects
AUDITORY perception testing ,BONE conduction ,EUSTACHIAN tube ,HEARING ,OTITIS media ,POSTOPERATIVE period ,TYMPANIC membrane ,TYMPANOPLASTY ,TREATMENT effectiveness ,PREOPERATIVE period - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
21. Microstate in resting state: an EEG indicator of tinnitus?
- Author
-
Cao, Wei, Wang, Fangyuan, Zhang, Chi, Lei, Guangxiong, Jiang, Qingqing, Shen, Weidong, and Yang, Shiming
- Subjects
CHRONIC disease diagnosis ,CEREBRAL cortex ,ELECTROENCEPHALOGRAPHY ,REGRESSION analysis ,STATISTICS ,TINNITUS ,DATA analysis ,VISUAL analog scale - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
22. The characteristics of monosyllable recognition in Mandarin-speaking patients with auditory neuropathy.
- Author
-
Xu, Liangwei, Chen, Wei, Yuan, Shuolong, Yang, Shiming, and Ji, Fei
- Subjects
AUDIOMETRY ,RECOGNITION (Psychology) ,TASK performance ,HUMAN research subjects ,PATIENT selection ,AUDITORY neuropathy - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
23. Larger tumor size and female gender suggest better tinnitus prognosis after surgical treatment in vestibular schwannoma patients with tinnitus.
- Author
-
Cao, Wei, Hou, Zhaohui, Wang, Fangyuan, Jiang, Qingqing, Shen, Weidong, and Yang, Shiming
- Subjects
ACOUSTIC neuroma ,BRAIN stem ,CONFIDENCE intervals ,MICROSURGERY ,POSTOPERATIVE period ,SEX distribution ,SURVIVAL ,TINNITUS ,TUMORS ,LOGISTIC regression analysis ,TREATMENT effectiveness ,RETROSPECTIVE studies ,ODDS ratio ,SYMPTOMS - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
24. Clinical characteristics of petrosal cholesteatoma and value of MRI-DWI in the diagnosis.
- Author
-
Zuo, Wenjing, Wang, Fangyuan, Yang, Shiming, Han, Dongyi, Dai, Pu, Shen, Weidong, Hou, Zhaohui, and Han, Weiju
- Subjects
CHOLESTEATOMA ,FACE ,FACIAL paralysis ,HEADACHE ,HEARING disorders ,MAGNETIC resonance imaging ,SPASMS ,VERTIGO ,RETROSPECTIVE studies ,SYMPTOMS - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
25. The use of the MUSS and the SIR scale in late-implanted prelingually deafened adolescents and adults as a subjective evaluation.
- Author
-
Liu, Riyuan, Jiao, Qingshan, Ji, Fei, Wang, Qian, Zhao, Hui, Li, Jianan, and Yang, Shiming
- Subjects
AUDITORY perception ,COCHLEAR implants ,DEAFNESS ,SPEECH perception ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
26. An investigation of life quality of patients after two different acoustic neuroma resections.
- Author
-
Ning, Fei, Zuo, Haiwei, Guo, Lei, Jiao, Changling, Xu, Xiaoping, Kong, Bingbing, and Yang, Shiming
- Subjects
ACOUSTIC neuroma ,HEALTH surveys ,MENTAL health ,OPERATIVE otolaryngology ,POSTOPERATIVE period ,QUALITY of life ,QUESTIONNAIRES ,NURSING interventions - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
27. Improvement of otoendoscopic surgery for epitympanic cholesteatoma invading the mastoid.
- Author
-
Wu, Nan, Wang, Fangyuan, Hou, Zhaohui, and Yang, Shiming
- Subjects
MASTOID process surgery ,MIDDLE ear anatomy ,TYMPANIC membrane surgery ,CHOLESTEATOMA ,EAR surgery ,EAR canal ,ENDOSCOPY ,MASTOID process ,MICROSCOPY ,POSTOPERATIVE period ,SURGICAL complications ,TYMPANIC membrane ,DISEASE relapse ,TREATMENT effectiveness - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
28. Acid stimulation-induced semi-pluripotent characteristics in human somatic cells.
- Author
-
Xu, Qing-Qing, Guo, Wei-Wei, Wang, Xiangdong, Zhai, Suoqiang, and Yang, Shiming
- Subjects
TREATMENT of deafness ,STEM cells ,ALKALINE phosphatase ,ANIMAL experimentation ,CELL differentiation ,CELLULAR therapy ,MICE ,POLYMERASE chain reaction ,FLUOROIMMUNOASSAY ,IN vitro studies ,PHYSIOLOGY - Abstract
Background: Clinical trials of cell-based therapies using induced pluripotent stem (iPS) cells have already been started for several neurological diseases. Objective: The purpose of the present study was to explore the characteristics and differentiation of somatic cells in vitro undergoing a low pH treatment, so as to provide new therapeutic strategies for treating sensorineural hearing loss. Methods: Somatic cells were treated with low pH solution to alter their characteristics. In addition, a mouse model of the cochlear lesion was constructed using bilirubin. Subsequently, the characteristics and therapeutic effect of somatic cells undergoing low pH treatment were examined by morphology, alkaline phosphatase (AKP) activity, immunofluorescence assay and q-PCR. Results: The cells in the experimental group grew better than those in the control group. The AKP activity in the experimental group was higher than that in the control group. The expression of Nanog and Oct4 was both positive in the two groups. When the cells were changed to neurobasal medium, the marker of nestin was positive. Conclusion: The human somatic cells undergoing a low pH treatment showed the similar characteristics as those of iPS cells, although the functions and therapeutic effect of these altered human somatic cells need to be further studied. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
29. Evaluation of microRNA expression profiling in highly metastatic laryngocarcinoma cells.
- Author
-
Chen, Liwei, Liu, Shaoyan, Li, Kun, Qi, Jixia, Liu, Chenqing, Zong, Liang, Zhang, Yongxia, Zhao, Jiandong, Zhai, Xingyou, Li, Jianhui, Kong, Xinru, Yang, Shiming, and Liu, Mingbo
- Subjects
CANCER invasiveness ,METASTASIS ,LARYNGEAL tumors ,ANIMAL experimentation ,LYMPH nodes ,MOLECULAR biology ,POLYMERASE chain reaction ,SQUAMOUS cell carcinoma ,BIOINFORMATICS ,DISEASE progression ,GENE expression profiling ,MICRORNA ,GENETICS - Abstract
Background: Until now, little is known about the role of miRNAs in the invasion and metastasis of Laryngeal squamous cell carcinoma (LSCC). Objectives: This study aimed to explore the relationship between microRNA and the invasion and metastasis of LSCC. Material and methods: The highly metastatic laryngocarcinoma cells were obtained from the established animal model with spontaneous lymph node metastasis of LSCC in our previous study. MicroRNA expression profiling and bioinformatic analysis were performed to analyze the microRNA expression changes in the highly metastatic laryngocarcinoma cells and the parental tumor cells (HEP-2). RT-PCR was performed for further validation of the result of microarray. Results: A total of 40 microRNAs were found to be significantly altered in the highly metastatic laryngocarcinoma cells compared to controls. Bioinformatic analysis identified that 19 key microRNAs might involve in LSCC development. Moreover, RT-PCR confirmed that miR-25, miR-100, miR-125b-5p and let-7g were differentially expressed in different laryngocarcinoma cells and human tumor specimens. Conclusions and significance: Our findings suggest that microRNA play an important role in the invasion and metastasis of LSCC, and provide the clues for studying the function of microRNA as well as opportunities to analyze the complex molecular abnormalities driving LSCC progression. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
30. Maximal number of pre-synaptic ribbons are formed in cochlear region corresponding to middle frequency in mice.
- Author
-
Yang, Le, Chen, DaiShi, Qu, TengFei, Ding, TongHui, Yan, AiHui, Gong, Pinggui, Liu, Yunyi, Zhang, Junjun, Gong, ShuSheng, Yang, ShiMing, Peng, Hong, and Liu, Ke
- Subjects
COCHLEA physiology ,ACTION potentials ,ANIMAL experimentation ,AUDITORY evoked response ,BRAIN mapping ,HAIR cells ,HEARING levels ,IMMUNOHISTOCHEMISTRY ,MICE ,MICROSCOPY ,NEURAL transmission ,ACOUSTIC stimulation - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
31. Transcription analysis of cochlear development in minipigs.
- Author
-
Wang, Qinghua, Zhang, Yan, Guo, Weiwei, Liu, Yu, Wei, Hong, and Yang, Shiming
- Subjects
ANIMAL experimentation ,COCHLEA ,GENE expression ,SWINE ,TRANSCRIPTION factors ,FETAL development - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
32. A method to induce human cortical long-term potentiation by acoustic stimulation.
- Author
-
Lei, Guanxiong, Zhao, Zeqi, Li, Yalan, Yu, Liming, Zhang, Xin, Yan, Yan, Ma, Xiaoyan, Wang, Qian, Wang, Keshuang, Zhang, Duo, Shen, Weidong, Qiao, Yuehua, and Yang, Shiming
- Subjects
AUDITORY cortex physiology ,BRAIN physiology ,ANALYSIS of variance ,AUDITORY evoked response ,ELECTROENCEPHALOGRAPHY ,HANDEDNESS ,NEURAL transmission ,NEUROLOGY ,NEURONS ,NOISE ,RESEARCH funding ,STATISTICS ,DATA analysis ,HUMAN research subjects ,PATIENT selection ,DATA analysis software ,DESCRIPTIVE statistics ,ACOUSTIC stimulation - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
33. Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss.
- Author
-
Chen, Liwei, Han, Mingkun, Lu, Yan, Chen, Daishi, Sun, Xuejun, Yang, Shiming, Sun, Wei, Yu, Ning, and Zhai, Suoqiang
- Subjects
HEARING disorder diagnosis ,ANALYSIS of variance ,ANIMAL experimentation ,COCHLEA ,HEARING disorders ,HYDROGEN ,INTERLEUKINS ,MOLECULAR biology ,NOISE ,PHYSIOLOGIC salines ,RESEARCH funding ,STATISTICS ,SWINE ,TUMOR necrosis factors ,DATA analysis ,CONTROL groups ,DATA analysis software - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
34. Adeno-associated virus transformation into the normal miniature pig and the normal guinea pigs cochlea via scala tympani.
- Author
-
Shi, Xunbei, Wu, Nan, Zhang, Yue, Guo, Weiwei, Lin, Chang, and Yang, Shiming
- Subjects
COCHLEA ,ANIMAL experimentation ,EXPERIMENTAL design ,GENE therapy ,GUINEA pigs ,HAIR cells ,SWINE ,VIRUSES ,ANATOMY - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
35. Unitary ototoxic gentamicin exposure may not disrupt the function of cochlear outer hair cells in mice.
- Author
-
Zhao, Ning, Tai, XuHui, Zhai, LiJie, Shi, Lin, Chen, DaiShi, Yang, Bo, Ji, Fei, Hou, Kun, Yang, ShiMing, Gong, ShuSheng, and Liu, Ke
- Subjects
ANIMAL experimentation ,ELECTRON microscopy ,GENTAMICIN ,HAIR cells ,HEARING disorders ,MICE ,PROBABILITY theory ,OTOTOXICITY ,PHYSIOLOGY - Abstract
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
36. Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae.
- Author
-
Xu, Yang, Yang, Wei Ping, Hu, Bo Hua, Yang, Shiming, and Henderson, Donald
- Subjects
AGING ,ANIMAL experimentation ,APOPTOSIS ,AUDITORY evoked response ,BRAIN stem ,CELL culture ,COCHLEA ,EPITHELIUM ,HAIR cells ,NECROSIS ,PROBABILITY theory ,RATS ,STAINS & staining (Microscopy) ,SIGNAL peptides ,DESCRIPTIVE statistics - Abstract
Conclusion: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. Objective: To determine molecular players in age-related hair cell degeneration, this study examined the changes in p53 and Bcl-2 expression at different stages of apoptotic and necrotic death of hair cells in aging rat cochleae. Methods: Young (3–4 months) and aging (23–24 months) Fisher 344/NHsd rats were used. The thresholds of the auditory brainstem response (ABR) were measured to determine the auditory function. Immunolabeling was performed to determine the expression of p53 and Bcl-2 proteins in the sensory epithelium. Propidium iodide staining was performed to determine the morphologic changes in hair cell nuclei. Results: Aging rats exhibited a significant elevation in ABR thresholds at all tested frequencies (p < 0.001). The p53 and Bcl-2 immunoreactivity was increased in aging hair cells showing the early signs of apoptotic changes in their nuclei. The Bcl-2 expression increase was also observed in hair cells displaying early signs of necrosis. As the hair cell degenerative process advanced, p53 and Bcl-2 immunoreactivity became reduced or absent. In the areas where no detectable nuclear staining was present, p53 and Bcl-2 immunoreactivity was absent. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
37. Establishing the standard method of cochlear implant in Rongchang pig.
- Author
-
Chen, Wei, Yi, Haijin, Zhang, Liang, Ji, Fei, Yuan, Shuolong, Zhang, Yue, Ren, Lili, Li, Jianan, Chen, Lei, Guo, Weiwei, and Yang, Shiming
- Subjects
ANIMAL experimentation ,AUDITORY evoked response ,BRAIN stem ,COCHLEAR implants ,EAR surgery ,SWINE ,TREATMENT effectiveness - Abstract
Conclusions:In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic. Objective:The aim of this study was to establish a standard method of cochlear implant in a large mammal—pig. Methods:Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf −/−). Cochlear implants were used and ABR and EABR were recorded. The implanted electrodes were observed by X-ray and HE stains. Results:The success with cochlear implant and the best electrode position could be defined in all animals, the coiling of the cochlea reached 1.5–1.75 turns. Immediately after the operation of cochlear implants, the ABR threshold of the operated ear (right) could not be derived for each frequency at 120 dB SPL. Moreover, 7 days after surgery, the low-frequency ABR threshold of the operated ear (right) could be derived partly at 100 dB SPL, but the high-frequency ABR threshold could not be derived at 120 dB SPL. Immediately or 1 week after cochlear implants, the EABR threshold was 90 CL in the Mitf +/+ group. This was obviously lower than the 190 CL in the Mitf −/− group. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
- View/download PDF
38. Anomaly Detection Outperforms Logistic Regression in Predicting Outcomes in Trauma Patients.
- Author
-
Dezman, Zachary D. W., Gao, Chen, Yang, Shiming, Hu, Peter, Yao, Li, Li, Hsiao-Chi, Chang, Chein-I., and Mackenzie, Colin
- Subjects
WOUNDS & injuries ,TREATMENT effectiveness ,BLOOD transfusion ,BLOOD platelet transfusion ,CHI-squared test ,CLASSIFICATION ,CRITICAL care medicine ,DIAGNOSIS ,HOSPITAL care ,LONGITUDINAL method ,MEDICAL needs assessment ,MEDICAL records ,PATIENTS ,RESUSCITATION ,T-test (Statistics) ,TIME ,TRAUMA centers ,VITAL signs ,LOGISTIC regression analysis ,RETROSPECTIVE studies ,RECEIVER operating characteristic curves ,HOSPITAL mortality ,PROGNOSIS - Abstract
Objective: Recent advancements in trauma resuscitation have shown a great benefit of early identification and control of hemorrhage, which is the most common cause of death in injured patients. We introduce a new analytical approach, anomaly detection (AD), as an alternative method to the traditional logistic regression (LR) method in predicting which injured patients receive transfusions, intensive care, and other interventions.Methods: We abstracted routinely collected prehospital vital sign data from patient records (adult patients who survived more than 15 minutes after being directly admitted to a level 1 trauma center). The vital signs of the study cohort were analyzed using both LR and AD methods. Predictions on blood transfusions generated by these approaches were compared with hospital records using the respective areas under the receiver operating characteristic curves (AUROC).Results: Of the patients seen at our trauma center between January 1, 2009, and December 31, 2010, 5,464 were included. AD significantly outperformed LR, identifying which patients would receive transfusions of uncrossmatched blood, transfusion of blood between the time of admission and 6 hours later, the need for intensive care, and in-hospital mortality (mean AUROC = 0.764 and 0.720, respectively). AD and LR provided similar predictions for the patients who would receive massive transfusion. Under the stratified 10 fold times 10 cross-validation test, AD also had significantly lower AUROC variance across subgroups than LR, suggesting AD is a more stable predictions model.Conclusions: AD provides enhanced predictions for clinically relevant outcomes in the trauma patient cohort studied and may assist providers in caring for acutely injured patients in the prehospital arena.Keywords: trauma; transfusion; vital signs; logistic regression; anomaly detection [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
- View/download PDF
39. Preliminary application of intra-operative hearing monitoring by tone pip ABR via loudspeakers.
- Author
-
Ren, Wei, Ji, Fei, Zeng, Jialing, Hao, Qingqing, Liu, Riyuan, Xu, Guangyu, Yan, Yan, Zhang, Miao, Zhao, Hui, and Yang, Shiming
- Subjects
AUDIOMETRY ,AUDITORY evoked response ,BRAIN stem ,CONFIDENCE intervals ,STATISTICAL correlation ,HEARING ,INTRAOPERATIVE care ,OPERATING rooms ,REGRESSION analysis ,RESEARCH funding ,T-test (Statistics) ,WAVE analysis ,DESCRIPTIVE statistics ,GENERAL anesthesia ,CONDUCTIVE hearing loss - Abstract
Conclusion:This method might be an effective intra-operative way to access hearing threshold under general anesthesia in the operating room. Objective:To develop an intra-operative hearing monitoring method for surgeons to access hearing threshold under general anesthesia in the operating room. Method:System establishment and calibration was done firstly. Normal hearing (NH) and conductive hearing loss (CHL) participants were recruited. This study applied pure tone audiometry (PTA) to all subjects and tone pip ABR (tp-ABR) via loudspeakers in sound booth and operating room for NH and CHL subjects, respectively. For NH subjects, Bland Altman was conducted to compare 1k Hz PTA and tp-ABR threshold. For CHL participants, Pairedt-test, Satterth waitet’-test, and linear correlation analysis were used to compare the two methods.p < .05 was considered statistically different. Results: (1) Bland Altman showed all plots were inside the 95% confidence interval, indicating that there was no difference between the two methods for NH subjects. (2) The two methods had a high correlation (Pearson’s coefficient =0.872 > 0.6,p < .05) in assessing hearing threshold in the operating room. (3) Satterth waitet’-test showed the ossicular chain malfunction enlarged the deviation of threshold by the two methods (.01 < p < .025). [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
- View/download PDF
40. Clinical analysis on surgical management of type III external auditory canal cholesteatoma: a report of 12 cases.
- Author
-
Yan, Yan, Dong, Siqi, Hao, Qingqing, Liu, Riyuan, Xu, Guangyu, Zhao, Hui, and Yang, Shiming
- Subjects
MASTOID process surgery ,BONES ,EAR canal ,MASTOID process ,AUTOGRAFTS ,CHOLESTEATOMA ,POSTOPERATIVE care ,RESEARCH funding ,PLASTIC surgery ,TYMPANOPLASTY ,RETROSPECTIVE studies ,ANATOMY - Abstract
Objective: To investigate surgical management of type III EACC with lesions involving the posterior external auditory canal and mastoid. Methods: This retrospective case review was conducted in 12 patients with type III EACC who underwent intact canal wall mastoidectomy with tympanoplasty and canal wall reconstruction with autologous cortical bone. Results: During the follow-up, all patients obtained successful results on external auditory canal structures and hearing improvement, except for one patient who needed a revision operation for the fistula between the reconstructed wall and the mastoid. Conclusion: Intact canal wall mastoidectomy with tympanoplasty and canal wall reconstruction with autologous cortical bone was proved to be an effective and inexpensive choice for the patients with type III external auditory canal cholesteatoma (EACC) to achieve optimal outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
41. Computer Modelling Using Prehospital Vitals Predicts Transfusion and Mortality.
- Author
-
Dezman, Zachary D. W., Hu, Eric, Hu, Peter F., Yang, Shiming, Stansbury, Lynn G., Cooke, Rhonda, Fang, Raymond, Miller, Catriona, and Mackenzie, Colin F.
- Subjects
BLOOD transfusion ,COMPUTER simulation ,REPORTING of diseases ,DOCUMENTATION ,EMERGENCY medical services ,EMERGENCY medicine ,LENGTH of stay in hospitals ,INTENSIVE care units ,MEDICAL needs assessment ,MORTALITY ,MEDICAL triage ,VITAL signs ,WOUNDS & injuries ,DECISION making in clinical medicine ,DATA analysis ,RECEIVER operating characteristic curves - Abstract
Objective:Test computer-assisted modeling techniques using prehospital vital signs of injured patients to predict emergency transfusion requirements, number of intensive care days, and mortality, compared to vital signs alone.Methods:This single-center retrospective analysis of 17,988 trauma patients used vital signs data collected between 2006 and 2012 to predict which patients would receive transfusion, require 3 or more days of intensive care, or die. Standard transmitted prehospital vital signs (heart rate, blood pressure, shock index, and respiratory rate) were used to create a regression model (PH-VS) that was internally validated and evaluated using area under the receiver operating curve (AUROC). Transfusion records were matched with blood bank records. Documentation of death and duration of intensive care were obtained from the trauma registry.Results:During the course of their hospital stay, 720 of the 17,988 patients in the study population died (4%), 2,266 (12.6%) required at least a 3-day stay in the intensive care unit (ICU), 1,171 (6.5%) required transfusions, and 210 (1.2%) received massive transfusions. The PH-VS model significantly outperformed any individual vital sign across all outcomes (average AUROC = 0.82), The PH-VS model correctly predicted that 512 of 777 (65.9%) and 580 of 931 (62.3%) patients in the study population would receive transfusions within the first 2 and 6 hours of admission, respectively.Conclusions:The predictive ability of individual vital signs to predict outcomes is significantly enhanced with the model. This could support prehospital triage by enhancing decision makers’ ability to match critically injured patients with appropriate resources with minimal delays. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
- View/download PDF
42. Predictive value of hyperthermia and intracranial hypertension on neurological outcomes in patients with severe traumatic brain injury.
- Author
-
Bonds, Brandon W., Hu, Peter, Li, Yao, Yang, Shiming, Colton, Katharine, Gonchigar, Anish, Cheriyan, Jerry, Grissom, Thomas, Fang, Raymond, and Stein, Deborah M.
- Subjects
BRAIN injuries ,BODY temperature ,FEVER ,LENGTH of stay in hospitals ,INTRACRANIAL hypertension ,EVALUATION of medical care ,RESEARCH funding ,PREDICTIVE tests ,SEVERITY of illness index ,RECEIVER operating characteristic curves ,DATA analysis software ,DESCRIPTIVE statistics ,GLASGOW Coma Scale ,PROGNOSIS - Abstract
Background: Intracranial hypertension (ICH) and hyperthermia are common after traumatic brain injury (TBI) and associated with worse neurological outcomes. This study sets out to determine the combined power of temperature and intracranial pressure (ICP) for predicting neurologic outcomes and prolonged length of stay (LOS) following severe TBI. Methods: High resolution (every 6 seconds) temperature and ICP data were collected in adults with severe TBI from 2008–2010. Temperatures were plotted against concurrent ICP and divided based on breakpoints (Temperature: <36, 36–38.5 or >38.5 °C, ICP: <20, 20–30 or >30 mmHg). The percentage of time spent in each section, as well as several pooled unfavourable conditions (hyperthermia ± ICH), were then evaluated for predictive value for ICU-LOS > 7 days and short-term (<6 months) vs. long-term (>6 months) dichotomized neurologic outcomes. Results: Fifty patients were included for analysis with severe TBI. Evaluation of the area under the operating receiver curve (AUC) showed significant periods of fever and high ICP (<30 mmHg) had a strong association with poor long-term neurological outcomes (Day 3, AUC = 0.71,p = 0.04) and were higher than either condition alone. ICU-LOS > 7 days was increased when hyperthermia and/or ICH remained uncontrolled by Day 5 (AUC = 0.82,p = 0.02). Summary: Hyperthermia combined with ICH were shown to be significant prognostic indicators of future poor neurologic outcomes in patients with severe traumatic brain injury. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
- Full Text
- View/download PDF
43. Noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in mice.
- Author
-
Shi, Lin, Liu, Ke, Wang, Haolin, Zhang, Yue, Hong, Zhijun, Wang, Mingyu, Wang, Xiaoyu, Jiang, Xuejun, and Yang, Shiming
- Subjects
GANGLIA ,HAIR cell anatomy ,ACOUSTIC nerve ,ANALYSIS of variance ,ANALYTICAL biochemistry ,ANIMAL experimentation ,COLLECTION & preservation of biological specimens ,NOISE-induced deafness ,HEARING levels ,IMMUNOHISTOCHEMISTRY ,MICE ,MICROSCOPY ,NEUROPLASTICITY ,PROBABILITY theory ,REGRESSION analysis ,RESEARCH funding ,STATISTICAL sampling ,STATISTICS ,T-test (Statistics) ,CYTOMETRY ,DATA analysis ,DATA analysis software ,DESCRIPTIVE statistics ,MANN Whitney U Test ,ANATOMY - Abstract
Conclusion: Noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss. The reduction of synaptic puncta appears reversible and may contribute to hearing restoration in mice after noise exposure. Objective: To detect whether noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in C57BL/6J mice. Methods: The mice were assigned randomly to five groups and exposed to white noise at 110 dB SPL for 2 h except the control group. ABR thresholds were acquired before noise exposure (control), immediately following exposure (Day 0), or on Days 4, 7, or 14 after noise exposure. Light microscopy, scanning emission microscopy, and whole mounts examination was utilized to study whether there is morphology change of outer hair cells (OHC), inner hair cells (IHC), or spiral ganglion cells (SGN) due to the 110 dB white noise. Moreover, experimental approaches, including immunostaining and confocal microcopy, were used to detect whether ribbon synapses were the primary targets of noise-induced temporary hearing loss. Result: Exposure to 110 dB white noise for 2 h induced TTS in mice, with the maximal ABR threshold elevations seen on the 4
th day after noise exposure. There were no significant morphological changes in the cochlea. Paralleled changes of pre-synaptic ribbons in both the number and post-synaptic density (PSDs) during this noise exposure were detected. The number of pre-synaptic ribbon, post-synaptic density (PSDs), and co-localized puncta correlated with the shifts of ABR thresholds. Moreover, a complete recovery of ABR thresholds and synaptic puncta was seen on the 14th day after the noise stimulations. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
44. SOX2 as prognostic factor in head and neck cancer: a systematic review and meta-analysis.
- Author
-
Li, Weimin, Li, Baoping, Wang, Rongguang, Huang, Dongyan, Jin, Wei, and Yang, Shiming
- Subjects
HEAD tumors ,NECK tumors ,CHI-squared test ,CONFIDENCE intervals ,MEDLINE ,META-analysis ,ONLINE information services ,RESEARCH funding ,SURVIVAL ,SYSTEMATIC reviews ,DATA analysis ,RELATIVE medical risk ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio ,GENETICS ,PROGNOSIS - Abstract
Conclusion: SOX2-positive head and neck cancer patients had a worse prognosis, and this was associated with common clinicopathological poor prognostic factors. Objective: To investigate the correlation between SOX2-positive head and neck cancer and clinicopathological features and its impact on survival. Methods: A search in PubMed and Chinese CNKI (up to 1 July 2013) was performed. Only articles in which SOX2 antigen was detected in situ localization by immunohistochemical staining were included. This meta-analysis was done using RevMan 5.2 software. Outcomes included overall survival and various clinicopathological features. Results: A total of 926 gastric cancer patients from 9 studies were included. Meta-analysis showed that patients with SOX2 expression had a significantly worse 5-year overall survival compared with those with low expression (relative risk (RR) = 2.38, 95% confidence interval (CI) = 1.10-5.15, p = 0.03, random-effect). With respect to clinicopathological features, SOX2 overexpression as assessed by the immunohistochemistry method was closely correlated with tumor T stage, lymph node metastasis, and TNM stage. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
45. Hemolysis in neonatal rats results in auditory impairment.
- Author
-
Li, Qi, Chen, Peipei, Guo, Weiwei, Fang, Ruping, and Yang, Shiming
- Subjects
HEARING disorders ,ELECTROPHYSIOLOGY methodology ,ANIMAL experimentation ,HEMOLYSIS & hemolysins ,IMMUNOHISTOCHEMISTRY ,NEONATAL jaundice ,RATS ,RESEARCH funding ,T-test (Statistics) ,DATA analysis software ,DESCRIPTIVE statistics ,DISEASE complications ,DISEASE risk factors - Abstract
Conclusion: This study suggests that hyperbilirubinemia in the neonatal rat can impair auditory function and induce peripheral nerve pathology by reducing neurofilament-positive cells in spiral ganglion neurons (SGNs). This finding indicates a potential connection between hyperbilirubinemia and auditory impairment. Objective: To establish a neonatal rat hyperbilirubinemia induced by hemolysis and assess the possible link between hyperbilirubinemia and auditory impairment. Methods: Wistar rats were divided into two groups - a bilirubin exposure group injected with phenylhydrazine hydrochloride at 7 and 28 days of age to induce hyperbilirubinemia, and a control group given saline. Auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) were determined to assess auditory function. Cochlea basilar membrane stretch preparations and cochlear frozen sections were examined for morphological changes in hair cells and SGNs. Results: At day 7, ABR wave I, III, and V latencies, and I-III, I-V interwave intervals (IWIs) in the experimental group were significantly prolonged compared with those in the control group. ABR thresholds were also elevated in the experimental group. We found no significant difference in DPOAEs in the bilirubin exposure group compared to the control group. The ABRs and DPOAEs in the experimental group were restored at age 28 days. Cochlear hair cells showed no signs of loss in either group; however, the total number of neurofilament-positive cells in SGNs was significantly reduced in the phenylhydrazine-treated animals. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
46. Shape from shading and optical flow used for 3-dimensional reconstruction of endoscope image.
- Author
-
Lei, Lei, Li, Jianhui, Liu, Meiqing, Hu, Xiaoming, Zhou, Ya, and Yang, Shiming
- Subjects
ENDOSCOPY ,PHOTOGRAPHY ,PHOTOMETRY ,STATISTICS ,THREE-dimensional imaging ,DATA analysis - Abstract
Conclusion: The shape from shading and optical flow are implemented to three-dimensional (3D) reconstruction. Objective: Solve the problem of 3D reconstruction in endoscope imaging. Method: One of the fundamental approaches in the domain of computer vision is shape from shading. This algorithm was proposed to obtain the shape of an object from a single intensity image. Because of the severe conditions are required in shape from shading to reconstruct 3D surface. The photometric calibration is proposed from the view of image processing. The calibration is important for illumination-based visualization techniques such as SFS (shape-from-shading). However, the surface reconstruction from SFS is the relative variation in the grey gradient field. So the change from relative variation to absolute variation is necessary when the actual size of surroundings has to be known. Then the optical flow is introduced to solve this change in the paper. The optical tracker is also used in this system to capture the pose of endoscopy. Result: The stability of surface reconstruction is improved when the photometric calibration is used before shape from shading. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
47. Myosin VIIa and otoferlin in cochlear inner hair cells have distinct response to ototoxic exposure.
- Author
-
Liu, Ke, Ji, Fei, Xu, YiCe, Wang, XiaoYu, Hou, ZhaoHui, and Yang, ShiMing
- Subjects
ANALYSIS of variance ,ANIMAL experimentation ,AUDITORY evoked response ,BRAIN stem ,COCHLEA ,GENTAMICIN ,HAIR cells ,HEARING disorders ,MICE ,MYOSIN ,RESEARCH funding ,WESTERN immunoblotting ,OTOTOXICITY ,DESCRIPTIVE statistics - Abstract
Conclusion: Ototoxic gentamicin exposure does not disrupt the expression of myosin VIIa in the inner hair cells (IHCs) of mice, whereas gentamicin ototoxicity causes altered expression of otoferlin in IHCs, as well as parallel hearing threshold shifts. Objective: To explore whether myosin VIIa and otoferlin in IHCs have different responses to gentamicin ototoxicity. Methods: Lower dose treatment (100 mg/kg): adult C57 mice were continuously injected intraperitoneally with gentamicin once a day for 14 consecutive days. Dose-dependent gentamicin treatment: mice were injected intraperitoneally with differing doses (100, 200, and 300 mg/kg) once a day for 2 consecutive days. The hearing thresholds were detected by auditory brainstem response (ABR). Immunostaining and Western blotting were utilized to measure the manner of expression of myosin VIIa and otoferlin in IHCs. Results: Lower dose treatment: There were no significant differences among the control (day 0), and 4, 7, and 14 days after the ototoxicity exposure ( p > 0.05). Dose-dependent gentamicin treatment: There were no significant differences among the control, 100, 200, and 300 mg/kg groups after the ototoxicity exposure ( p > 0.05). In contrast, we found an altered expression of otoferlin in IHCs among the control (day 0), and 4, 7, and 14 days of exposure, when the mice were exposed to gentamicin ototoxicity ( p > 0.05). [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
48. Analysis of the performance of post-lingually deafened patients with Nurotron® Venus™ cochlear implants.
- Author
-
Li, Jianan, Ji, Fei, Chen, Wei, Zhao, Hui, Han, Dongyi, and Yang, Shiming
- Subjects
AUDITORY perception testing ,CLINICAL trials ,COCHLEAR implants ,COMPARATIVE studies ,DEAFNESS ,HEALTH outcome assessment ,PROSTHETICS ,RESEARCH funding ,SPEECH perception ,T-test (Statistics) ,TREATMENT effectiveness ,DESCRIPTIVE statistics - Abstract
Objective: The aim of this study was to analyze the safety and effectiveness of a new cochlear implant (CI) system developed in China, the Nurotron Venus device. Material and methods: Fifteen post-lingually deafened patients received Nurotron Venus CIs in our hospital. The safety and effectiveness of the devices were evaluated within 2 years after implantation. Patients' hearing thresholds were assessed. In addition, the speech perception performance of Nurotron Venus CI recipients was compared with that of 15 Cochlear Nucleus CI24 recipients. Results and conclusion: During 2 years of observation, all the Nurotron recipients used their devices regularly and effectively. The aided hearing thresholds of all the recipients were within the speech spectrum. The average scores of HOPE sentences and HOPE monosyllable words tests among Nurotron CI recipients were 82.88 ± 21.40% and 56.67 ± 9.77%, respectively. The average scores among Cochlear Nucleus CI24 recipients were 87.33 ± 14.44% and 52.8 ± 12.76%, respectively. There was no statistically significant difference in the speech test scores between these two groups when assessed using the t test. The Nurotron Venus cochlear implant system worked safely and effectively. The speech perception of Nurotron recipients was similar to that of the other CI system recipients. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
49. Subtotal facial nerve decompression for recurrent facial palsy in Melkersson Rosenthal syndrome.
- Author
-
Dai, Chuanfu, Li, Jiandong, Yang, Shiming, Zhao, Liang, Feng, Shui, Li, Yang, Song, Zhiyao, Lu, Jieyu, and Zhao, Kun
- Subjects
SURGICAL decompression ,DISEASE relapse prevention ,FACIAL nerve diseases ,FACIAL paralysis ,LONGITUDINAL method ,DESCRIPTIVE statistics ,DISEASE complications - Abstract
Conclusions: Subtotal facial nerve decompression seems effective to prevent further episodes of facial palsy and promote facial nerve recovery for recurrent facial palsy in Melkersson Rosenthal syndrome (MRS). The main inflammatory sites of recurrent facial palsy in MRS may be the mastoid segment, tympanic segment, geniculate ganglion, and labyrinthine segment. Objective: To present our surgical experience in preventing further episodes of facial palsy and improving facial nerve recovery of patients with recurrent facial palsy in MRS. Methods: We performed transmastoid subtotal facial nerve decompression on eight patients with recurrent facial palsy in MRS. They were followed up for 3.3 years on average (range 2-5 years). Results: There were no further attacks of facial palsy in any of the cases. Seven cases (87.5%) recovered to grade I or grade II, and three of eight cases (37.5%) recovered completely. We found obvious edema of the facial nerve at the mastoid segment in all cases, at the tympanic segment and geniculate ganglion in five cases (62.5%), and at the labyrinthine segment in only one case (12.5%). [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
50. Dynamic distribution of ototoxic gentamicin entry into inner hair cells of mice.
- Author
-
Liu, Ke, Shi, Chuang, Sun, YuHan, Xu, YiCe, Shi, Lei, Shi, Lin, Wang, XiaoYu, Ji, Fei, Hou, ZhaoHui, and Yang, ShiMing
- Subjects
AMINOGLYCOSIDES ,ANALYSIS of variance ,ANIMAL experimentation ,AUDITORY evoked response ,BRAIN stem ,COCHLEA ,DEAFNESS ,GENTAMICIN ,HAIR cells ,IMMUNOLOGY technique ,INNER ear ,MICE ,RESEARCH funding ,SCANNING electron microscopy ,OTOTOXICITY ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Conclusion: Dynamic distribution of ototoxic gentamicin entry into inner hair cells (IHCs) may cause an interruption of cochlear ribbon synapse. Objective: To explore the pattern of uptake of gentamicin into IHCs, as well as its possible contribution to hearing loss. Methods: Adult C57 mice were injected intraperitoneally with gentamicin (100 mg/kg, conjugated with Texas Red ester) continuously for 14 days. The hearing thresholds were detected by auditory brainstem response (ABR) examinations. Immunostaining and confocal microscopy were utilized to trace gentamicin distribution, as well as the expression of RIBEYE/CtBP2 in mouse IHCs. Scanning electron microscopy (SEM) observation was used to find possible alterations of stereocilia. Results: The distribution of gentamicin in IHCs was first found on the 4th day and the accumulation of gentamicin was increased significantly on the 7th day after treatment, corresponding to the maximal elevation of the hearing threshold. However, the accumulation of gentamicin on the 14th day did not show significant differences compared with the level found on the 7th day. In addition, the uptake of gentamicin was excessively identified at or near the synaptic ribbons of IHCs throughout the 4th, 7th, and 14th days after the treatment, suggesting that cochlear ribbon synapses could be affected by ototoxic gentamicin exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.