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Injectable implants with the ability to form in situ are one of the most promising carriers for the delivery of chemotherapeutic drugs to tumor sites. We have reported a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA), ethyl oleate, along with the sol-gel phase transition. The chemotherapeutic drug-loaded injectable NBCA ethyl oleate implant (INEI) exhibited excellent therapeutic efficacy for local chemotherapy. Herein, we utilize this INEI to carry N, N′-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) (TE-C-5003), which is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, to treat the lung cancer mice model. The in vitro experiment shows that TE-C-5003 has a good anti-tumor effect on lung cancer (IC50 = 0.7022 µM for A549; IC50 = 0.6844 µM for NCL-H1299) and breast cancer (IC50 = 0.4128 µM for MCF-7; IC50 = 0.5965 µM for MDA-MB-231). Anti-tumor experiments in animal models showed that the average growth inhibition rate of xenografted human lung cancer cells by the TE-C-5003-loaded INEI (40% NBCA) was 68.23%, which is far more than TC-E-5003 alone (31.76%). Our study further confirms that INEI is an effective technique to improve the anti-tumor effect. The druggability of small molecule compounds can be improved with the help of the mentioned technology. Also, TC-E-5003 may be developed as a broad spectrum anti-tumor drug. [ABSTRACT FROM AUTHOR]

This paper reports a novel solid-mounted flexible film bulk acoustic resonator (FBAR) directly on polymer substrate with the merits of flexibility and no need for back etching process. (0002) oriented ZnO films deposited by sputtering, and aluminum and gold as the electrodes were used to fabricate the FBARs. Results show that the devices with aluminum electrodes have a resonant frequency at 1.2 GHz with an effective electromechanical coupling coefficient of ∼ 4.7%, a filter-like architecture improved the quality factor of FBAR from 19.6 to 164.2, and the devices remained working after bending at a large angle for hundreds of times. [ABSTRACT FROM PUBLISHER]

Controlling the thin-film nano- and microstructure of active components in organic-based electronic devices such as organic field-effect transistors, organic light-emitting diodes and organic photovoltaic devices is still a challenging but crucial task [Sirringhaus H, Brown PJ, Friend RH, Nielsen MM, Bechgaard K, Langeveld-Voss BMW, Spiering AJH, Janssen RAJ, Meijer EW, Herwig P, de Leeuw DM. Two-dimensional charge transport in self-organized, high-mobility conjugated polymers. Nature. 1999;401:685-688; Yu G, Gao J, Hummelen JC, Wudl F, Heeger AJ. Polymer photovoltaic cells: enhanced efficiencies via a network of internal donor-acceptor heterojunctions. Science. 1995;270:1789-1791; Ray B, Alam MA. Optimum morphology and performance gains of organic solar cells. 2011 37th IEEE Photovoltaic Specialists Conference. IEEE;2011;2:003477-003481]. Over the past decade, numerous strategies have been explored for this purpose, including chemical modification of relevant materials and substrates, optimisation of existing processing procedures (through selection of solvents and processing conditions, annealing procedures, etc.), as well as the development of entirely new deposition techniques [Subramanian S, Park SK, Parkin SR, Podzorov V, Jackson TN, Anthony JE. Chromophore fluorination enhances crystallization and stability of soluble anthradithiophene semiconductors. J. Am. Chem. Soc. 2008;130:2706-2707; Reese C, Roberts M, Ling M, Bao Z. Organic thin film transistors. Mater. Today. 2004;7:20-27; Halik M, Klauk H, Zschieschang U, Maisch S, Effenberger F, Dehm C, Schu M, Brunnbauer M, Stellacci F. Low-voltage organic transistors with an amorphous molecular gate dielectric. Nature. 2004;431:963-966; Kim CS, Lee S, Gomez ED, Anthony JE, Loo YL. Solvent-dependent electrical characteristics and stability of organic thin-film transistors with drop cast bis(triisopropylsilylethynyl) pentacene. Appl. Phys. Lett. 2008;93:103302-103304; Dickey KC, Anthony JE, Loo YL. Improving organic thin-film transistor performance through solvent-vapor annealing of solution-processable triethylsilylethynyl anthradithiophene. Adv. Mater. 2006;18:1721-1726; Street RA. Thin-film transistors. Adv. Mater. 2009;21:2007-2022; de Gans BJ, Duineveld PC, Schubert US. Inkjet printing of polymers: state of the art and future developments. Adv. Mater. 2004;16:203-213; Krebs FC. Fabrication and processing of polymer solar cells: a review of printing and coating techniques. Sol. Energy Mater. Sol. Cells. 2009;93:394-412]. Additives have thereby been shown to provide extra means to significantly influence the molecular assembly and order in the solid state of the active species [Peet J, Kim JY, Coates NE, Ma WL, Moses D, Heeger AJ, Bazan GC. Efficiency enhancement in low-bandgap polymer solar cells by processing with alkane dithiols. Nat. Mater. 2007;6:497-500; Wei Q, Lin Y, Anderson ER, Briseno AL, Gido SP, Watkins JJ. Additive-driven assembly of block copolymer-nanoparticle hybrid materials for solution processable floating gate memory. ACS Nano. 2012;6:1188-1194]. Here, we will discuss the use of a class of additives that can form molecular compounds with the active materials, adding to the extensive tool box for microstructural control because crystalline solid-state structures can be realised where chromophores are spatially separated from each other by the additive molecules without compromising the overall long-range order of the system. [ABSTRACT FROM AUTHOR]